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255 results

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The following term was not found in PubMed: Khairabadi
Page 1
Laron syndrome - A historical perspective.
Laron Z, Werner H. Laron Z, et al. Rev Endocr Metab Disord. 2021 Mar;22(1):31-41. doi: 10.1007/s11154-020-09595-0. Epub 2020 Sep 22. Rev Endocr Metab Disord. 2021. PMID: 32964395 Review.
The treatment is by recombinant IGF-I, which improves the height and restores some of the metabolic parameters. An unexpected finding was that patients homozygous for GH-R defects are protected from malignancy lifelong, not so heterozygotes or double heterozygote su …
The treatment is by recombinant IGF-I, which improves the height and restores some of the metabolic parameters. An unexpected finding was th …
Two years in growth hormone 2017-18.
Clayton PE, Whatmore AJ. Clayton PE, et al. Growth Horm IGF Res. 2019 Oct-Dec;48-49:60-64. doi: 10.1016/j.ghir.2019.10.003. Epub 2019 Oct 24. Growth Horm IGF Res. 2019. PMID: 31706073 Review.
Long term surveillance is a vital part of therapeutics; recent studies across Europe have provided reassurance on the safety of recombinant human GH (r-hGH) for those with uncomplicated growth disorders, but do emphasise the need to continue observation through adul …
Long term surveillance is a vital part of therapeutics; recent studies across Europe have provided reassurance on the safety of recombinant …
Increased GH/IGF-I Axis Activity Relates to Lower Hepatic Lipids and Phosphor Metabolism.
Fellinger P, Beiglböck H, Semmler G, Pfleger L, Smajis S, Baumgartner C, Gajdosik M, Marculescu R, Vila G, Winhofer Y, Scherer T, Trauner M, Kautzky-Willer A, Krssak M, Krebs M, Wolf P. Fellinger P, et al. J Clin Endocrinol Metab. 2023 Sep 18;108(10):e989-e997. doi: 10.1210/clinem/dgad206. J Clin Endocrinol Metab. 2023. PMID: 37104943 Free PMC article.

RESULTS: In the overall cohort (40.6 15 years; body mass index: 24.5 3 kg/m2; IGF-I: 68.0 17% upper limit of normal), fasting GH (R = -0.31; P = .02), GH during oral glucose tolerance test (R = -0.51; P < .01), and IGF-I (R = -0.28; P = .03) inversely correlated

…
RESULTS: In the overall cohort (40.6 15 years; body mass index: 24.5 3 kg/m2; IGF-I: 68.0 17% upper limit of normal), fasting GH ( …
The role of the GH/IGF-I axis for cardiac function and structure.
Isgaard J, Tivesten A, Friberg P, Bengtsson BA. Isgaard J, et al. Horm Metab Res. 1999 Feb-Mar;31(2-3):50-4. doi: 10.1055/s-2007-978698. Horm Metab Res. 1999. PMID: 10226781 Review.
Moreover, GH has been found to regulate local production of IGF-I in the heart. Both the GH-R and IGF-I-R are expressed in cardiac tissue. Hence, the IGF-I-R receptor can theoretically be activated through locally produced IGF-I acting via autocrine/paracrine mechan …
Moreover, GH has been found to regulate local production of IGF-I in the heart. Both the GH-R and IGF-I-R are expressed in car …
Secretagogues and the somatotrope: signaling and proliferation.
Frohman LA, Kineman RD, Kamegai J, Park S, Teixeira LT, Coschigano KT, Kopchic JJ. Frohman LA, et al. Recent Prog Horm Res. 2000;55:269-90; discussion 290-1. Recent Prog Horm Res. 2000. PMID: 11036941 Review.
Overall, the results indicate a complex regulation of GH secretion in which somatotrope receptor, as well as ligand expression, exerts an important physiological role. Both the SDR and the GH-R knockout (ko) mouse have small pituitaries and decreased somatotropes, d …
Overall, the results indicate a complex regulation of GH secretion in which somatotrope receptor, as well as ligand expression, exerts an im …
Presence of growth hormone receptor (GH-R) mRNA and protein in goat ovarian follicles and improvement of in vitro preantral follicle survival and development with GH.
Martins FS, Saraiva MV, Magalhães-Padilha DM, Almeida AP, Celestino JJ, Padilha RT, Cunha RM, Silva JR, Campello CC, Figueiredo JR. Martins FS, et al. Theriogenology. 2014 Jul 1;82(1):27-35. doi: 10.1016/j.theriogenology.2014.02.019. Epub 2014 Mar 2. Theriogenology. 2014. PMID: 24725418
The ovaries were processed for the isolation of follicles to study GH-R mRNA expression or to localization of GH-R by immunohistochemical analysis. ...However, preantral follicles do not express mRNA for GH-R. Immunohistochemistry demonst …
The ovaries were processed for the isolation of follicles to study GH-R mRNA expression or to localization of GH-R …
Myokines in Acromegaly: An Altered Irisin Profile.
Mizera Ł, Halupczok-Żyła J, Kolačkov K, Zembska A, Grzegrzółka J, Jędrzejuk D, Bolanowski M, Daroszewski J. Mizera Ł, et al. Front Endocrinol (Lausanne). 2021 Nov 2;12:728734. doi: 10.3389/fendo.2021.728734. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34795636 Free PMC article.
There were no differences between study group and controls in myostatin concentration. Myostatin levels negatively correlated with GH (r = -0.306; p = 0.049), HOMA-IR (r = -0.046; p = 0.411), and insulin levels (r = -0.429; p = 0.016). ...
There were no differences between study group and controls in myostatin concentration. Myostatin levels negatively correlated with GH …
GH deficiency status combined with GH receptor polymorphism affects response to GH in children.
Valsesia A, Chatelain P, Stevens A, Peterkova VA, Belgorosky A, Maghnie M, Antoniazzi F, Koledova E, Wojcik J, Farmer P, Destenaves B, Clayton P; PREDICT Investigator group. Valsesia A, et al. Eur J Endocrinol. 2015 Dec;173(6):777-89. doi: 10.1530/EJE-15-0474. Epub 2015 Sep 4. Eur J Endocrinol. 2015. PMID: 26340968 Free PMC article.
Meta-analysis has shown a modest improvement in first-year growth response to recombinant human GH (r-hGH) for carriers of the exon 3-deleted GH receptor (GHRd3) polymorphism but with significant interstudy variability. ...
Meta-analysis has shown a modest improvement in first-year growth response to recombinant human GH (r-hGH) for carriers of the …
Effects of growth hormone overexpression and growth hormone resistance on neuroendocrine and reproductive functions in transgenic and knock-out mice.
Bartke A, Chandrashekar V, Turyn D, Steger RW, Debeljuk L, Winters TA, Mattison JA, Danilovich NA, Croson W, Wernsing DR, Kopchick JJ. Bartke A, et al. Proc Soc Exp Biol Med. 1999 Nov;222(2):113-23. doi: 10.1046/j.1525-1373.1999.d01-121.x. Proc Soc Exp Biol Med. 1999. PMID: 10564535 Review.
In both models of GH resistance, there are marked reproductive deficits in females, decline of breeding performance of males, and alterations in the function of the HPG axis. In GH-R-KO females, puberty is delayed, and litter size is reduced. ...However, reproductiv …
In both models of GH resistance, there are marked reproductive deficits in females, decline of breeding performance of males, and alteration …
255 results