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Growth hormone responsive neural precursor cells reside within the adult mammalian brain.
Blackmore DG, Reynolds BA, Golmohammadi MG, Large B, Aguilar RM, Haro L, Waters MJ, Rietze RL. Blackmore DG, et al. Sci Rep. 2012;2:250. doi: 10.1038/srep00250. Epub 2012 Feb 7. Sci Rep. 2012. PMID: 22355762 Free PMC article.
The detection of growth hormone (GH) and its receptor in germinal regions of the mammalian brain prompted our investigation of GH and its role in the regulation of endogenous neural precursor cell activity. Here we report that the addition of exogenous GH sig …
The detection of growth hormone (GH) and its receptor in germinal regions of the mammalian brain prompted our investigation of GH …
Exercise increases neural stem cell number in a growth hormone-dependent manner, augmenting the regenerative response in aged mice.
Blackmore DG, Golmohammadi MG, Large B, Waters MJ, Rietze RL. Blackmore DG, et al. Stem Cells. 2009 Aug;27(8):2044-52. doi: 10.1002/stem.120. Stem Cells. 2009. PMID: 19544415
Importantly, and consistent with the demonstrated ability of growth hormone (GH) to increase NSC proliferation, and the elevated secretion of GH during exercise, exercise failed to stimulate NSCs in GH receptor-null mice. These findings now provide a novel ba …
Importantly, and consistent with the demonstrated ability of growth hormone (GH) to increase NSC proliferation, and the elevated secr …