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Page 1
Evaluation of omadacycline against intracellular Mycobacterium abscessus in an infection model in human macrophages.
Jahanbakhsh S, Howland J, Ndayishimiye Uwineza MO, Thwaites MT, Pillar CM, Serio AW, Anastasiou DM, Hufnagel DA. Jahanbakhsh S, et al. JAC Antimicrob Resist. 2023 Sep 15;5(5):dlad104. doi: 10.1093/jacamr/dlad104. eCollection 2023 Oct. JAC Antimicrob Resist. 2023. PMID: 37720564 Free PMC article.
Intracellular M. abscessus was then challenged with omadacycline and control antibiotics at multiples of the MIC over time to evaluate intracellular killing. RESULTS: At 16 the MIC at 72 h, omadacycline treatment of intracellular NTM yielded a log(10) reduction in cfu of 1 …
Intracellular M. abscessus was then challenged with omadacycline and control antibiotics at multiples of the MIC over time to evaluate intra …
Effects of Exosomes Derived From Helicobacter pylori Outer Membrane Vesicle-Infected Hepatocytes on Hepatic Stellate Cell Activation and Liver Fibrosis Induction.
Zahmatkesh ME, Jahanbakhsh M, Hoseini N, Shegefti S, Peymani A, Dabin H, Samimi R, Bolori S. Zahmatkesh ME, et al. Front Cell Infect Microbiol. 2022 Jun 27;12:857570. doi: 10.3389/fcimb.2022.857570. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35832384 Free PMC article.
Outer membrane vesicles (OMVs) are one of the most important discussed H. pylori virulence factors. In the current study, four different clinical strains of H. pylori were collected and their OMVs were purified using ultra-centrifugation. ...Our results showed that …
Outer membrane vesicles (OMVs) are one of the most important discussed H. pylori virulence factors. In the current study, four differ …
The inhibition of lactoperoxidase catalytic activity through mesna (2-mercaptoethane sodium sulfonate).
Jahanbakhsh S, Dekhne MS, Kohan-Ghadr HR, Bai D, Awonuga A, Morris RT, Yang Z, Abu-Soud HM. Jahanbakhsh S, et al. J Inorg Biochem. 2020 Feb;203:110911. doi: 10.1016/j.jinorgbio.2019.110911. Epub 2019 Nov 12. J Inorg Biochem. 2020. PMID: 31734539
Lactoperoxidase is a hemoprotein that utilizes hydrogen peroxide (H(2)O(2)) and thiocyanate (SCN(-)) to produce hypothiocyanous acid (HOSCN), an antimicrobial agent also thought to be associated with carcinogenesis. ...Mesna inhibits LPO's halogenation activity (IC(50) val …
Lactoperoxidase is a hemoprotein that utilizes hydrogen peroxide (H(2)O(2)) and thiocyanate (SCN(-)) to produce hypothiocyanous acid …
Evaluation of Telavancin Alone and Combined with Ceftaroline or Rifampin against Methicillin-Resistant Staphylococcus aureus in an In Vitro Biofilm Model.
Jahanbakhsh S, Singh NB, Yim J, Rose WE, Rybak MJ. Jahanbakhsh S, et al. Antimicrob Agents Chemother. 2018 Jul 27;62(8):e00567-18. doi: 10.1128/AAC.00567-18. Print 2018 Aug. Antimicrob Agents Chemother. 2018. PMID: 29784849 Free PMC article.
Our objective was to evaluate two telavancin (TLV) dosage regimens (7.5 mg/kg of body weight and 10 mg/kg every 24 h [q24h]) alone and in combination with ceftaroline (CPT) (600 mg every 8 h [q8h]) or rifampin (RIF) (450 mg every 12 h [q12h]) against two biof …
Our objective was to evaluate two telavancin (TLV) dosage regimens (7.5 mg/kg of body weight and 10 mg/kg every 24 h [q24h]) alone an …
A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B).
François-Moutal L, Jahanbakhsh S, Nelson ADL, Ray D, Scott DD, Hennefarth MR, Moutal A, Perez-Miller S, Ambrose AJ, Al-Shamari A, Coursodon P, Meechoovet B, Reiman R, Lyons E, Beilstein M, Chapman E, Morris QD, Van Keuren-Jensen K, Hughes TR, Khanna R, Koehler C, Jen J, Gokhale V, Khanna M. François-Moutal L, et al. ACS Chem Biol. 2018 Oct 19;13(10):3000-3010. doi: 10.1021/acschembio.8b00745. Epub 2018 Sep 6. ACS Chem Biol. 2018. PMID: 30141626 Free PMC article.
Impact of cefazolin co-administration with vancomycin to reduce development of vancomycin-intermediate Staphylococcus aureus.
Singh NB, Yim J, Jahanbakhsh S, Sakoulas G, Rybak MJ. Singh NB, et al. Diagn Microbiol Infect Dis. 2018 Aug;91(4):363-370. doi: 10.1016/j.diagmicrobio.2018.03.020. Epub 2018 Apr 7. Diagn Microbiol Infect Dis. 2018. PMID: 29807674
Our objective was to demonstrate that development of resistance under conditions of suboptimal VAN (200 mg q 12 h) exposure in S. aureus can be attenuated by addition of cefazolin (CFZ). ...RESULTS: VAN MIC of both organisms increased from 1 to 4 mg/L within 144 h u …
Our objective was to demonstrate that development of resistance under conditions of suboptimal VAN (200 mg q 12 h) exposure in S. aur …
Sept8/SEPTIN8 involvement in cellular structure and kidney damage is identified by genetic mapping and a novel human tubule hypoxic model.
Keele GR, Prokop JW, He H, Holl K, Littrell J, Deal AW, Kim Y, Kyle PB, Attipoe E, Johnson AC, Uhl KL, Sirpilla OL, Jahanbakhsh S, Robinson M, Levy S, Valdar W, Garrett MR, Solberg Woods LC. Keele GR, et al. Sci Rep. 2021 Jan 22;11(1):2071. doi: 10.1038/s41598-021-81550-8. Sci Rep. 2021. PMID: 33483609 Free PMC article.
Leishmanicidal and cytotoxic activities of Nigella sativa and its active principle, thymoquinone.
Mahmoudvand H, Tavakoli R, Sharififar F, Minaie K, Ezatpour B, Jahanbakhsh S, Sharifi I. Mahmoudvand H, et al. Pharm Biol. 2015 Jul;53(7):1052-7. doi: 10.3109/13880209.2014.957784. Epub 2014 Dec 4. Pharm Biol. 2015. PMID: 25471014
MATERIALS AND METHODS: Antileishmanial effects of essential oil and methanolic extract of N. sativa (0-200 g/mL) and thymoquinone (0-25 g/mL) on promastigotes of both species and their cytotoxicity activities against murine macrophages were evaluated using the MTT assay at 24, 48 …
MATERIALS AND METHODS: Antileishmanial effects of essential oil and methanolic extract of N. sativa (0-200 g/mL) and thymoquinone (0-25 g/mL …
16 results