Autocrine vitamin D signaling switches off pro-inflammatory programs of T(H)1 cells.
Chauss D, Freiwald T, McGregor R, Yan B, Wang L, Nova-Lamperti E, Kumar D, Zhang Z, Teague H, West EE, Vannella KM, Ramos-Benitez MJ, Bibby J, Kelly A, Malik A, Freeman AF, Schwartz DM, Portilla D, Chertow DS, John S, Lavender P, Kemper C, Lombardi G, Mehta NN, Cooper N, Lionakis MS, Laurence A, Kazemian M, Afzali B.
Chauss D, et al.
Nat Immunol. 2022 Jan;23(1):62-74. doi: 10.1038/s41590-021-01080-3. Epub 2021 Nov 11.
Nat Immunol. 2022.
PMID: 34764490
Free PMC article.
The molecular mechanisms governing orderly shutdown and retraction of CD4(+) type 1 helper T (T(H)1) cell responses remain poorly understood. Here we show that complement triggers contraction of T(H)1 responses by inducing intrinsic expression of the vitamin D (VitD …
The molecular mechanisms governing orderly shutdown and retraction of CD4(+) type 1 helper T (T(H)1) cell responses remain poorly und …