Novel purine derivatives mitigate hypoxia ischemia related brain injury through agrin, zyxin and synaptotagmin proteins.
Mabondzo A, Disdier C, Bouzid A, Larbi KS, Tsintzou A, Maïza A, Kim B, Costa N, Harati R, Nguyen AL, Pruvost A, Galons H, Oumata N, Armengaud J, Knijnenburg M, Verma G, Hagberg H, Gressens P, Chen XF, Hamoudi RA, Stonestreet BS.
Mabondzo A, et al.
Neurotherapeutics. 2025 Sep;22(5):e00621. doi: 10.1016/j.neurot.2025.e00621. Epub 2025 Jun 17.
Neurotherapeutics. 2025.
PMID: 40533307
Free PMC article.
Postnatal day-7 rats exposed to sham surgery or carotid ligation and 8% FiO(2) for 90 min were given BRT_002 (30 mg/kg) or placebo intraperitoneally (IP) immediately, 24, and 48 h after the induction of HI. Pharmacokinetic studies revealed suitable systemic and brain expos …
Postnatal day-7 rats exposed to sham surgery or carotid ligation and 8% FiO(2) for 90 min were given BRT_002 (30 mg/kg) or placebo intraperi …