Efficacy of AiiM, an N-acylhomoserine lactonase, against Pseudomonas aeruginosa in a mouse model of acute pneumonia.
Migiyama Y, Kaneko Y, Yanagihara K, Morohoshi T, Morinaga Y, Nakamura S, Miyazaki T, Hasegawa H, Izumikawa K, Kakeya H, Kohrogi H, Kohno S.
Migiyama Y, et al. Among authors: morohoshi t.
Antimicrob Agents Chemother. 2013 Aug;57(8):3653-8. doi: 10.1128/AAC.00456-13. Epub 2013 May 20.
Antimicrob Agents Chemother. 2013.
PMID: 23689715
Free PMC article.
Lung histopathology, bacterial burden, and bronchoalveolar lavage (BAL) fluid were assessed at 24 h postinfection. AiiM expression in PAO1 reduced production of AHL-mediated virulence factors and attenuated cytotoxicity against human lung epithelial cells. ...
Lung histopathology, bacterial burden, and bronchoalveolar lavage (BAL) fluid were assessed at 24 h postinfection. AiiM expression in …