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An injectable thermosensitive hydrogel/nanomicelles composite for local chemo-immunotherapy in mouse model of melanoma.
Akbari V, Hejazi E, Minaiyan M, Emami J, Lavasanifar A, Rezazadeh M. Akbari V, et al. J Biomater Appl. 2022 Sep;37(3):551-562. doi: 10.1177/08853282221098232. Epub 2022 May 11. J Biomater Appl. 2022. PMID: 35543695
Here, we prepared a thermosensitive hydrogel based hyaluronic acid (HA) encapsulated with macrophage colony-stimulating factor (GM-CSF) and paclitaxel (PTX) for chemoimmunotherapy of cancer. ...In the following step, thermosensitive hydrogel using PF127 and HA was p …
Here, we prepared a thermosensitive hydrogel based hyaluronic acid (HA) encapsulated with macrophage colony-stimulating factor (GM-CS …
Preparation and in vitro characterization of histidine trimethyl chitosan conjugated nanocomplex incorporated into injectable thermosensitive hydrogels for localized gene delivery.
Akbari V, Rezazadeh M, Hanaie NS, Hasanzadeh F. Akbari V, et al. Biotechnol Appl Biochem. 2022 Jun;69(3):1047-1057. doi: 10.1002/bab.2175. Epub 2021 May 2. Biotechnol Appl Biochem. 2022. PMID: 33878804
Based on gel retardation assay, polyplex dissociation following incubation with heparin, protection against DNase iota, cytotoxicity and transfection experiments, HTMC/pDNA at N/P 15 was selected as an optimized formulation and loaded into CTS/PF127 and HA/PF127 hydrogel. …
Based on gel retardation assay, polyplex dissociation following incubation with heparin, protection against DNase iota, cytotoxicity and tra …
Preparation and characterization of an injectable thermosensitive hydrogel for simultaneous delivery of paclitaxel and doxorubicin.
Rezazadeh M, Akbari V, Amuaghae E, Emami J. Rezazadeh M, et al. Res Pharm Sci. 2018 Jun;13(3):181-191. doi: 10.4103/1735-5362.228918. Res Pharm Sci. 2018. PMID: 29853928 Free PMC article.
In the second step, the optimized PTX-loaded micelles prepared in the first step were incorporated into the thermosensitive Pluronic F127/hyaluronic acid (PF127/HA) hydrogel containing fixed amount of DOX. Gel formation temperature, rheological properties, injectability, d …
In the second step, the optimized PTX-loaded micelles prepared in the first step were incorporated into the thermosensitive Pluronic F127/hy …
Incorporation of rosuvastatin-loaded chitosan/chondroitin sulfate nanoparticles into a thermosensitive hydrogel for bone tissue engineering: preparation, characterization, and cellular behavior.
Rezazadeh M, Parandeh M, Akbari V, Ebrahimi Z, Taheri A. Rezazadeh M, et al. Pharm Dev Technol. 2019 Mar;24(3):357-367. doi: 10.1080/10837450.2018.1484765. Epub 2018 Jul 23. Pharm Dev Technol. 2019. PMID: 29863957
Consequently, optimized RSV-loaded nanoparticles were incorporated into the PF127/HA hydrogel. Rheological properties, degradation rates of hydrogels, and the release rate of RSV from hydrogel were examined. ...As revealed by cytotoxicity and mineralization assays, incorpo …
Consequently, optimized RSV-loaded nanoparticles were incorporated into the PF127/HA hydrogel. Rheological properties, degradation ra …
Comparison the effects of chitosan and hyaluronic acid-based thermally sensitive hydrogels containing rosuvastatin on human osteoblast-like MG-63 cells.
Akbari V, Rezazadeh M, Ebrahimi Z. Akbari V, et al. Res Pharm Sci. 2020 Feb 20;15(1):97-106. doi: 10.4103/1735-5362.278719. eCollection 2020 Feb. Res Pharm Sci. 2020. PMID: 32180821 Free PMC article.
Secondly, the effect of NRSV-embedded in CTS/GP/G on cell viability, alkaline phosphate activity, and cell calcification was evaluated using MG-63 cells and compared with RSV-embedded into hyaluronic acid (HA)/Pluronic() F127 (PF127) hydrogel. FINDINGS / RESULTS: CTS/GP mi …
Secondly, the effect of NRSV-embedded in CTS/GP/G on cell viability, alkaline phosphate activity, and cell calcification was evaluated using …