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Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia.
Fushimi N, Fujikura H, Shiohara H, Teranishi H, Shimizu K, Yonekubo S, Ohno K, Miyagi T, Itoh F, Shibazaki T, Tomae M, Ishikawa-Takemura Y, Nakabayashi T, Kamada N, Ozawa T, Kobayashi S, Isaji M. Fushimi N, et al. Among authors: ishikawa takemura y. Bioorg Med Chem. 2012 Nov 15;20(22):6598-612. doi: 10.1016/j.bmc.2012.09.037. Epub 2012 Sep 24. Bioorg Med Chem. 2012. PMID: 23062824
Design, synthesis, and structure-activity relationships of a series of 4-benzyl-5-isopropyl-1H-pyrazol-3-yl β-D-glycopyranosides substituted with novel hydrophilic groups as highly potent inhibitors of sodium glucose co-transporter 1 (SGLT1).
Fushimi N, Teranishi H, Shimizu K, Yonekubo S, Ohno K, Miyagi T, Itoh F, Shibazaki T, Tomae M, Ishikawa-Takemura Y, Nakabayashi T, Kamada N, Yamauchi Y, Kobayashi S, Isaji M. Fushimi N, et al. Among authors: ishikawa takemura y. Bioorg Med Chem. 2013 Feb 1;21(3):748-65. doi: 10.1016/j.bmc.2012.11.041. Epub 2012 Dec 5. Bioorg Med Chem. 2013. PMID: 23273606