Exploration of the physical states of riboflavin (free base) by mechanical milling.
Henaff C, Siepmann J, Siepmann F, Danède F, Avettand-Fènoël MN, Vérin J, Fadel A, Willart JF.
Henaff C, et al.
Int J Pharm. 2023 Oct 15;645:123416. doi: 10.1016/j.ijpharm.2023.123416. Epub 2023 Sep 15.
Int J Pharm. 2023.
PMID: 37716485
The glass transition temperature (Tg) and heat capacity (Cp) jump of the amorphous form were determined as 144 C and 0.68 J/g/C. Moreover, the relative physical stability of the different physical states has been elucidated, e.g., at room temperature: I > II > III. . …
The glass transition temperature (Tg) and heat capacity (Cp) jump of the amorphous form were determined as 144 C and 0.68 J/g/C. More …