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Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats.

Jalkanen AJ, Ihalainen J, Lehtonen M, Forsberg MM, Rautio J, Huttunen KM, Gynther M. Jalkanen AJ, et al. Int J Pharm. 2021 Mar 1;596:120300. doi: 10.1016/j.ijpharm.2021.120300. Epub 2021 Feb 1. Int J Pharm. 2021. PMID: 33540026 Free article.

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Extracellular prolyl oligopeptidase derived from activated microglia is a potential neuroprotection target.

Natunen TA, Gynther M, Rostalski H, Jaako K, Jalkanen AJ. Natunen TA, et al. Among authors: jalkanen aj. Basic Clin Pharmacol Toxicol. 2019 Jan;124(1):40-49. doi: 10.1111/bcpt.13094. Epub 2018 Aug 14. Basic Clin Pharmacol Toxicol. 2019. PMID: 29998529 Free article.

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Selective adrenergic alpha2C receptor antagonist ameliorates acute phencyclidine-induced schizophrenia-like social interaction deficits in rats.

Savolainen K, Ihalainen J, Jalkanen AJ, Forsberg MM. Savolainen K, et al. Among authors: jalkanen aj. Psychopharmacology (Berl). 2019 Apr;236(4):1245-1253. doi: 10.1007/s00213-018-5130-2. Epub 2018 Dec 10. Psychopharmacology (Berl). 2019. PMID: 30535904 Free PMC article.

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Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson's Disease.

Zhurakovskaya E, Leikas J, Pirttimäki T, Casas Mon F, Gynther M, Aliev R, Rantamäki T, Tanila H, Forsberg MM, Gröhn O, Paasonen J, Jalkanen AJ. Zhurakovskaya E, et al. Among authors: jalkanen aj. eNeuro. 2019 Feb 26;6(1):ENEURO.0456-18.2019. doi: 10.1523/ENEURO.0456-18.2019. eCollection 2019 Jan-Feb. eNeuro. 2019. PMID: 30838323 Free PMC article.

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Brain pharmacokinetics of ganciclovir in rats with orthotopic BT4C glioma.

Gynther M, Kääriäinen TM, Hakkarainen JJ, Jalkanen AJ, Petsalo A, Lehtonen M, Peura L, Kurkipuro J, Samaranayake H, Ylä-Herttuala S, Rautio J, Forsberg MM. Gynther M, et al. Among authors: jalkanen aj. Drug Metab Dispos. 2015 Jan;43(1):140-6. doi: 10.1124/dmd.114.059840. Epub 2014 Oct 27. Drug Metab Dispos. 2015. PMID: 25349125

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Combined ipsilateral limb use score as an index of motor deficits and neurorestoration in parkinsonian rats.

Leikas JV, Kääriäinen TM, Jalkanen AJ, Lehtonen M, Rantamäki T, Forsberg MM. Leikas JV, et al. Among authors: jalkanen aj. J Neurosci Res. 2017 Sep;95(9):1858-1870. doi: 10.1002/jnr.24022. Epub 2017 Jan 30. J Neurosci Res. 2017. PMID: 28134996

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KYP-2047 penetrates mouse brain and effectively inhibits mouse prolyl oligopeptidase.

Jalkanen AJ, Leikas JV, Forsberg MM. Jalkanen AJ, et al. Basic Clin Pharmacol Toxicol. 2014 Jun;114(6):460-3. doi: 10.1111/bcpt.12184. Epub 2014 Jan 25. Basic Clin Pharmacol Toxicol. 2014. PMID: 24350801 Free article.

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Prolyl oligopeptidase inhibition decreases extracellular acetylcholine levels in rat hippocampus and prefrontal cortex.

Jalkanen AJ, Leikas JV, Forsberg MM. Jalkanen AJ, et al. Neurosci Lett. 2014 Sep 5;579:110-3. doi: 10.1016/j.neulet.2014.07.026. Epub 2014 Jul 23. Neurosci Lett. 2014. PMID: 25064702

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Brief isoflurane anesthesia regulates striatal AKT-GSK3β signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease.

Leikas JV, Kohtala S, Theilmann W, Jalkanen AJ, Forsberg MM, Rantamäki T. Leikas JV, et al. Among authors: jalkanen aj. J Neurochem. 2017 Aug;142(3):456-463. doi: 10.1111/jnc.14066. Epub 2017 Jun 14. J Neurochem. 2017. PMID: 28488766 Free PMC article.

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Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat.

Jalkanen AJ, Hakkarainen JJ, Lehtonen M, Venäläinen T, Kääriäinen TM, Jarho E, Suhonen M, Forsberg MM. Jalkanen AJ, et al. Basic Clin Pharmacol Toxicol. 2011 Dec;109(6):443-51. doi: 10.1111/j.1742-7843.2011.00747.x. Epub 2011 Jul 28. Basic Clin Pharmacol Toxicol. 2011. PMID: 21707925 Free article.

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