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Year Number of Results
2007 1
2014 3
2016 1
2017 2
2018 1
2019 3
2020 7
2021 3
2022 6
2023 1
2024 1

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27 results

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Page 1
Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement.
Kapadia SR, Makkar R, Leon M, Abdel-Wahab M, Waggoner T, Massberg S, Rottbauer W, Horr S, Sondergaard L, Karha J, Gooley R, Satler L, Stoler RC, Messé SR, Baron SJ, Seeger J, Kodali S, Krishnaswamy A, Thourani VH, Harrington K, Pocock S, Modolo R, Allocco DJ, Meredith IT, Linke A; PROTECTED TAVR Investigators. Kapadia SR, et al. N Engl J Med. 2022 Oct 6;387(14):1253-1263. doi: 10.1056/NEJMoa2204961. Epub 2022 Sep 17. N Engl J Med. 2022. PMID: 36121045 Clinical Trial.
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
Tachmazidou I, Hatzikotoulas K, Southam L, Esparza-Gordillo J, Haberland V, Zheng J, Johnson T, Koprulu M, Zengini E, Steinberg J, Wilkinson JM, Bhatnagar S, Hoffman JD, Buchan N, Süveges D; arcOGEN Consortium; Yerges-Armstrong L, Smith GD, Gaunt TR, Scott RA, McCarthy LC, Zeggini E. Tachmazidou I, et al. Nat Genet. 2019 Feb;51(2):230-236. doi: 10.1038/s41588-018-0327-1. Epub 2019 Jan 21. Nat Genet. 2019. PMID: 30664745 Free PMC article.
Ten of the likely effector genes, including TGFB1 (transforming growth factor beta 1), FGF18 (fibroblast growth factor 18), CTSK (cathepsin K), and IL11 (interleukin 11), have therapeutics approved or in clinical trials, with mechanisms of action supportive of evaluation f …
Ten of the likely effector genes, including TGFB1 (transforming growth factor beta 1), FGF18 (fibroblast growth factor 18), CTSK (cathepsin …
TGFβ-induced changes in membrane curvature influence Ras oncoprotein membrane localization.
Damalas A, Vonkova I, Tutkus M, Stamou D. Damalas A, et al. Sci Rep. 2022 Aug 5;12(1):13486. doi: 10.1038/s41598-022-17482-8. Sci Rep. 2022. PMID: 35931724 Free PMC article.
Type and number of the lipid anchors are the main difference among three Ras variants-H-ras, N-ras and K-ras. The lipid anchors determine membrane partitioning of lipidated proteins into membrane areas of specific physico-chemical properties and curvature. In this study, w …
Type and number of the lipid anchors are the main difference among three Ras variants-H-ras, N-ras and K-ras. The lipid anchors deter …
Oral fosfomycin activity against Klebsiella pneumoniae in a dynamic bladder infection in vitro model.
Abbott IJ, van Gorp E, Wyres KL, Wallis SC, Roberts JA, Meletiadis J, Peleg AY. Abbott IJ, et al. J Antimicrob Chemother. 2022 Apr 27;77(5):1324-1333. doi: 10.1093/jac/dkac045. J Antimicrob Chemother. 2022. PMID: 35211736 Free PMC article.
METHODS: A multicompartment bladder infection in vitro model was used with standard media and synthetic human urine (SHU) to simulate urinary fosfomycin exposure after a single 3 g oral dose (fAUC0-72 16884 mg.h/L, t 5.5 h) against 15 K. pneumoniae isolates including ATCC …
METHODS: A multicompartment bladder infection in vitro model was used with standard media and synthetic human urine (SHU) to simulate urinar …
MixInYeast: A Multicenter Study on Mixed Yeast Infections.
Medina N, Soto-Debrán JC, Seidel D, Akyar I, Badali H, Barac A, Bretagne S, Cag Y, Cassagne C, Castro C, Chakrabarti A, Dannaoui E, Cardozo C, Garcia-Rodriguez J, Guitard J, Hamal P, Hoenigl M, Jagielski T, Khodavaisy S, Lo Cascio G, Martínez-Rubio MC, Meletiadis J, Muñoz P, Ochman E, Peláez T, Perez-Ayala Balzola A, Prattes J, Roilides E, Ruíz-Pérez de Pipaón M, Stauf R, Steinmann J, Suárez-Barrenechea AI, Tejero R, Trovato L, Viñuela L, Wongsuk T, Żak I, Zarrinfar H, Lass-Flörl C, Arikan-Akdagli S, Alastruey-Izquierdo A. Medina N, et al. J Fungi (Basel). 2020 Dec 29;7(1):13. doi: 10.3390/jof7010013. J Fungi (Basel). 2020. PMID: 33383783 Free PMC article.
Impact of bacterial species and baseline resistance on fosfomycin efficacy in urinary tract infections.
Abbott IJ, Dekker J, van Gorp E, Wijma RA, Raaphorst MN, Klaassen CHW, Meletiadis J, Mouton JW, Peleg AY. Abbott IJ, et al. J Antimicrob Chemother. 2020 Apr 1;75(4):988-996. doi: 10.1093/jac/dkz519. J Antimicrob Chemother. 2020. PMID: 31873748
All E. coli isolates were fosA negative. In contrast, 17 of 20 K. pneumoniae regrew post exposure, 6 with emergence of HLR (proportion = 0.01%-100%). ...CONCLUSIONS: E. coli and K. pneumoniae isolates demonstrate discrepant responses to a single fosfomycin dose in a …
All E. coli isolates were fosA negative. In contrast, 17 of 20 K. pneumoniae regrew post exposure, 6 with emergence of HLR (proportio …
27 results