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1980 1
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292 results

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Page 1
LASP1 in Tumor and Tumor Microenvironment.
Hu Z, Wang X, Cui Y, Li C, Wang S. Hu Z, et al. Curr Mol Med. 2017;17(8):541-548. doi: 10.2174/1566524018666180222115103. Curr Mol Med. 2017. PMID: 29473505 Review.
LASP1 expression is correlated with the grade, size, and the metastasis of tumor in clinical samples. ...The underlying mechanism of LASP1 on tumor is still in the initial stage; therefore, the signaling pathways in various tumors are specifically summarized to deep
LASP1 expression is correlated with the grade, size, and the metastasis of tumor in clinical samples. ...The underlying mechanism of
LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator.
Butt E, Howard CM, Raman D. Butt E, et al. Cells. 2022 Nov 29;11(23):3817. doi: 10.3390/cells11233817. Cells. 2022. PMID: 36497077 Free PMC article. Review.
These novel functions are primarily regulated by the site-specific phosphorylation of LASP1. This review will focus on specific phosphorylation-dependent interaction between LASP1 and cellular proteins that orchestrate primary tumor progression and metastasis. More …
These novel functions are primarily regulated by the site-specific phosphorylation of LASP1. This review will focus on specific phosp …
Hippocampal LASP1 ameliorates chronic stress-mediated behavioral responses in a mouse model of unpredictable chronic mild stress.
Cui YH, Fu A, Wang XQ, Tu BX, Chen KZ, Wang YK, Hu QG, Wang LF, Hu ZL, Pan PH, Li F, Bi FF, Li CQ. Cui YH, et al. Neuropharmacology. 2021 Feb 15;184:108410. doi: 10.1016/j.neuropharm.2020.108410. Epub 2020 Nov 23. Neuropharmacology. 2021. PMID: 33242526
However, the role of LASP1 in the regulation of mood is still unclear. Here, using an unpredictable chronic mild stress (UCMS) paradigm, we found that the mRNA and protein levels of LASP1 were decreased in the hippocampus of stressed mice and that UCMS-induced down- …
However, the role of LASP1 in the regulation of mood is still unclear. Here, using an unpredictable chronic mild stress (UCMS) paradi …
Lasp1 Expression Is Implicated in Embryonic Development of Zebrafish.
Grossi I, Schiavone M, Cannone E, Grejdan OA, Tobia C, Bonomini F, Rezzani R, Salvi A, De Petro G. Grossi I, et al. Genes (Basel). 2022 Dec 22;14(1):35. doi: 10.3390/genes14010035. Genes (Basel). 2022. PMID: 36672776 Free PMC article.
Further, we showed that specific lasp1 morpholino (MO) led to (i) abnormal morphants with alterations in several organs, (ii) effective knockdown of endogenous Lasp1 protein and (iii) an increase in lasp1 mRNA, as detected by ddPCR. The co-injection of las
Further, we showed that specific lasp1 morpholino (MO) led to (i) abnormal morphants with alterations in several organs, (ii) effecti …
New Frontiers for the Cytoskeletal Protein LASP1.
Butt E, Raman D. Butt E, et al. Front Oncol. 2018 Sep 21;8:391. doi: 10.3389/fonc.2018.00391. eCollection 2018. Front Oncol. 2018. PMID: 30298118 Free PMC article. Review.
In the recent two decades, LIM and SH3 protein 1 (LASP1) has been developed from a simple actin-binding structural protein to a tumor biomarker and subsequently to a complex, nuclear transcriptional regulator. Starting with a brief historical perspective, this review will …
In the recent two decades, LIM and SH3 protein 1 (LASP1) has been developed from a simple actin-binding structural protein to a tumor …
LASP1 Induces Epithelial-Mesenchymal Transition in Lung Cancer through the TGF-beta1/Smad/Snail Pathway.
Xue Q, Jiang H, Wang J, Wei D. Xue Q, et al. Can Respir J. 2021 Dec 6;2021:5277409. doi: 10.1155/2021/5277409. eCollection 2021. Can Respir J. 2021. PMID: 34912481 Free PMC article.
Activity of key Smad proteins (pSmad2 and pSmad3) and protein level of Smad7 were markedly regulated through LASP1. Furthermore, LASP1 affected the nuclear localizations of pSmad2, pSmad3, and Snail1. ...Therefore, LASP1 might be a drug target in lung cancer. …
Activity of key Smad proteins (pSmad2 and pSmad3) and protein level of Smad7 were markedly regulated through LASP1. Furthermore, L
Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis.
Beckmann D, Römer-Hillmann A, Krause A, Hansen U, Wehmeyer C, Intemann J, de Gorter DJJ, Dankbar B, Hillen J, Heitzmann M, Begemann I, Galic M, Weinhage T, Foell D, Ai R, Kremerskothen J, Kiener HP, Müller S, Kamradt T, Schröder C, Leitão E, Horsthemke B, Rosenstiel P, Nordström K, Gasparoni G, Gasparoni N, Walter J, Li N, Yang X, Chung HR, Pavenstädt H, Lindemann N, Schnittler HJ, Wang W, Firestein GS, Pap T, Korb-Pap A. Beckmann D, et al. Nat Commun. 2021 Jun 15;12(1):3624. doi: 10.1038/s41467-021-23706-8. Nat Commun. 2021. PMID: 34131132 Free PMC article.
However, the regulation of Lasp1 and its function in the aggressive transformation of cells is unclear. ...In arthritic human TNF transgenic mice, deletion of Lasp1 reduces arthritic joint destruction. Therefore, we show a function of Lasp1 in cellular juncti …
However, the regulation of Lasp1 and its function in the aggressive transformation of cells is unclear. ...In arthritic human TNF tra …
LASP1, CERS6, and Actin Form a Ternary Complex That Promotes Cancer Cell Migration.
Niimi A, Limsirichaikul S, Kano K, Mizutani Y, Takeuchi T, Sawangsri P, Tran DQ, Kawamoto Y, Suzuki M. Niimi A, et al. Cancers (Basel). 2023 May 16;15(10):2781. doi: 10.3390/cancers15102781. Cancers (Basel). 2023. PMID: 37345118 Free PMC article.
Both LASP1 and CERS6 showed co-immunoprecipitation with actin, with those interactions markedly reduced when the LASP1-CERS6 complex was abolished. Based on these findings, it is proposed that LASP1-CERS6 interaction promotes cancer cell migration....
Both LASP1 and CERS6 showed co-immunoprecipitation with actin, with those interactions markedly reduced when the LASP1-CERS6 c …
LASP1 promotes proliferation, metastasis, invasion in head and neck squamous cell carcinoma and through direct interaction with HSPA1A.
Chen Q, Wu K, Qin X, Yu Y, Wang X, Wei K. Chen Q, et al. J Cell Mol Med. 2020 Jan;24(2):1626-1639. doi: 10.1111/jcmm.14854. Epub 2019 Dec 2. J Cell Mol Med. 2020. PMID: 31793711 Free PMC article.
Co-immunoprecipitation analysis was performed to confirm the interaction between LASP1 and HSPA1A. LASP1 was highly expressed in HNSCC and associated with poor prognosis for patients. ...LASP1 and HSPA1A are both up-regulated in HNSCC, and directly binds to e …
Co-immunoprecipitation analysis was performed to confirm the interaction between LASP1 and HSPA1A. LASP1 was highly expressed …
292 results