Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 1
1995 1
1996 1
1998 3
1999 1
2000 1
2002 4
2003 4
2004 7
2005 3
2006 13
2007 6
2008 10
2009 11
2010 8
2011 3
2012 15
2013 13
2014 14
2015 8
2016 22
2017 28
2018 15
2019 21
2020 35
2021 34
2022 24
2023 17
2024 15

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

297 results

Results by year

Filters applied: . Clear all
Page 1
LASP1 in Tumor and Tumor Microenvironment.
Hu Z, Wang X, Cui Y, Li C, Wang S. Hu Z, et al. Curr Mol Med. 2017;17(8):541-548. doi: 10.2174/1566524018666180222115103. Curr Mol Med. 2017. PMID: 29473505 Review.
LASP1 expression is correlated with the grade, size, and the metastasis of tumor in clinical samples. ...The underlying mechanism of LASP1 on tumor is still in the initial stage; therefore, the signaling pathways in various tumors are specifically summarized to deep …
LASP1 expression is correlated with the grade, size, and the metastasis of tumor in clinical samples. ...The underlying mechanism of …
LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator.
Butt E, Howard CM, Raman D. Butt E, et al. Cells. 2022 Nov 29;11(23):3817. doi: 10.3390/cells11233817. Cells. 2022. PMID: 36497077 Free PMC article. Review.
These novel functions are primarily regulated by the site-specific phosphorylation of LASP1. This review will focus on specific phosphorylation-dependent interaction between LASP1 and cellular proteins that orchestrate primary tumor progression and metastasis. More …
These novel functions are primarily regulated by the site-specific phosphorylation of LASP1. This review will focus on specific phosp …
Lasp1 Expression Is Implicated in Embryonic Development of Zebrafish.
Grossi I, Schiavone M, Cannone E, Grejdan OA, Tobia C, Bonomini F, Rezzani R, Salvi A, De Petro G. Grossi I, et al. Genes (Basel). 2022 Dec 22;14(1):35. doi: 10.3390/genes14010035. Genes (Basel). 2022. PMID: 36672776 Free PMC article.
Further, we showed that specific lasp1 morpholino (MO) led to (i) abnormal morphants with alterations in several organs, (ii) effective knockdown of endogenous Lasp1 protein and (iii) an increase in lasp1 mRNA, as detected by ddPCR. The co-injection of las …
Further, we showed that specific lasp1 morpholino (MO) led to (i) abnormal morphants with alterations in several organs, (ii) effecti …
New Frontiers for the Cytoskeletal Protein LASP1.
Butt E, Raman D. Butt E, et al. Front Oncol. 2018 Sep 21;8:391. doi: 10.3389/fonc.2018.00391. eCollection 2018. Front Oncol. 2018. PMID: 30298118 Free PMC article. Review.
In the recent two decades, LIM and SH3 protein 1 (LASP1) has been developed from a simple actin-binding structural protein to a tumor biomarker and subsequently to a complex, nuclear transcriptional regulator. Starting with a brief historical perspective, this review will …
In the recent two decades, LIM and SH3 protein 1 (LASP1) has been developed from a simple actin-binding structural protein to a tumor …
Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis.
Beckmann D, Römer-Hillmann A, Krause A, Hansen U, Wehmeyer C, Intemann J, de Gorter DJJ, Dankbar B, Hillen J, Heitzmann M, Begemann I, Galic M, Weinhage T, Foell D, Ai R, Kremerskothen J, Kiener HP, Müller S, Kamradt T, Schröder C, Leitão E, Horsthemke B, Rosenstiel P, Nordström K, Gasparoni G, Gasparoni N, Walter J, Li N, Yang X, Chung HR, Pavenstädt H, Lindemann N, Schnittler HJ, Wang W, Firestein GS, Pap T, Korb-Pap A. Beckmann D, et al. Nat Commun. 2021 Jun 15;12(1):3624. doi: 10.1038/s41467-021-23706-8. Nat Commun. 2021. PMID: 34131132 Free PMC article.
In vitro, loss or blocking of Lasp1 alters pathological tissue formation, migratory behaviour and platelet-derived growth factor response of arthritic FLS. In arthritic human TNF transgenic mice, deletion of Lasp1 reduces arthritic joint destruction. Therefore, we s …
In vitro, loss or blocking of Lasp1 alters pathological tissue formation, migratory behaviour and platelet-derived growth factor resp …
LASP1 Induces Epithelial-Mesenchymal Transition in Lung Cancer through the TGF-beta1/Smad/Snail Pathway.
Xue Q, Jiang H, Wang J, Wei D. Xue Q, et al. Can Respir J. 2021 Dec 6;2021:5277409. doi: 10.1155/2021/5277409. eCollection 2021. Can Respir J. 2021. PMID: 34912481 Free PMC article.
Activity of key Smad proteins (pSmad2 and pSmad3) and protein level of Smad7 were markedly regulated through LASP1. Furthermore, LASP1 affected the nuclear localizations of pSmad2, pSmad3, and Snail1. ...Therefore, LASP1 might be a drug target in lung cancer. …
Activity of key Smad proteins (pSmad2 and pSmad3) and protein level of Smad7 were markedly regulated through LASP1. Furthermore, L …
LASP1, CERS6, and Actin Form a Ternary Complex That Promotes Cancer Cell Migration.
Niimi A, Limsirichaikul S, Kano K, Mizutani Y, Takeuchi T, Sawangsri P, Tran DQ, Kawamoto Y, Suzuki M. Niimi A, et al. Cancers (Basel). 2023 May 16;15(10):2781. doi: 10.3390/cancers15102781. Cancers (Basel). 2023. PMID: 37345118 Free PMC article.
Both LASP1 and CERS6 showed co-immunoprecipitation with actin, with those interactions markedly reduced when the LASP1-CERS6 complex was abolished. Based on these findings, it is proposed that LASP1-CERS6 interaction promotes cancer cell migration....
Both LASP1 and CERS6 showed co-immunoprecipitation with actin, with those interactions markedly reduced when the LASP1-CERS6 c …
Hippocampal LASP1 ameliorates chronic stress-mediated behavioral responses in a mouse model of unpredictable chronic mild stress.
Cui YH, Fu A, Wang XQ, Tu BX, Chen KZ, Wang YK, Hu QG, Wang LF, Hu ZL, Pan PH, Li F, Bi FF, Li CQ. Cui YH, et al. Neuropharmacology. 2021 Feb 15;184:108410. doi: 10.1016/j.neuropharm.2020.108410. Epub 2020 Nov 23. Neuropharmacology. 2021. PMID: 33242526
However, the role of LASP1 in the regulation of mood is still unclear. Here, using an unpredictable chronic mild stress (UCMS) paradigm, we found that the mRNA and protein levels of LASP1 were decreased in the hippocampus of stressed mice and that UCMS-induced down- …
However, the role of LASP1 in the regulation of mood is still unclear. Here, using an unpredictable chronic mild stress (UCMS) paradi …
LASP1 interacts with N-WASP to activate the Arp2/3 complex and facilitate colorectal cancer metastasis by increasing tumour budding and worsening the pattern of invasion.
Yan P, Liu J, Zhou R, Lin C, Wu K, Yang S, Yang S, Zhou J, Xu L, Wang H, Zhao L. Yan P, et al. Oncogene. 2020 Aug;39(35):5743-5755. doi: 10.1038/s41388-020-01397-7. Epub 2020 Jul 23. Oncogene. 2020. PMID: 32704133
As the major biological and pathological functions of LASP1 are accomplished by its LIM and SH3 domains via protein-protein interactions, a yeast two-hybrid system was employed to screen novel LASP1-interacting proteins. ...Our study suggests a new mechanism for …
As the major biological and pathological functions of LASP1 are accomplished by its LIM and SH3 domains via protein-protein interacti …
LASP1 induces colorectal cancer proliferation and invasiveness through Hippo signaling and Nanog mediated EMT.
Chen N, Han X, Bai X, Yin B, Wang Y. Chen N, et al. Am J Transl Res. 2020 Oct 15;12(10):6490-6500. eCollection 2020. Am J Transl Res. 2020. PMID: 33194046 Free PMC article.
In the present study, we performed immunohistochemistry (IHC) staining for LASP1 and found that LASP1 expression was higher in CRC tissue of advanced stage. Over-expressed (OE) LASP1 promoted proliferation, tumorigenesis and migration of CRC cell lines SW480 …
In the present study, we performed immunohistochemistry (IHC) staining for LASP1 and found that LASP1 expression was higher in …
297 results