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Transcriptomic changes following valproic acid treatment promote neurogenesis and minimize secondary brain injury.
J Trauma Acute Care Surg. 2018 Mar;84(3):459-465. doi: 10.1097/TA.0000000000001765.
J Trauma Acute Care Surg. 2018.
PMID: 29251707
Free PMC article.
Valproic acid induces prosurvival transcriptomic changes in swine subjected to traumatic injury and hemorrhagic shock.
Georgoff PE, Nikolian VC, Higgins G, Chtraklin K, Eidy H, Ghandour MH, Williams A, Athey B, Alam HB.
Georgoff PE, et al.
J Trauma Acute Care Surg. 2018 Apr;84(4):642-649. doi: 10.1097/TA.0000000000001763.
J Trauma Acute Care Surg. 2018.
PMID: 29251706
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Isoform 6-selective histone deacetylase inhibition reduces lesion size and brain swelling following traumatic brain injury and hemorrhagic shock.
Nikolian VC, Dennahy IS, Weykamp M, Williams AM, Bhatti UF, Eidy H, Ghandour MH, Chtraklin K, Li Y, Alam HB.
Nikolian VC, et al.
J Trauma Acute Care Surg. 2019 Feb;86(2):232-239. doi: 10.1097/TA.0000000000002119.
J Trauma Acute Care Surg. 2019.
PMID: 30399139
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Valproic acid decreases brain lesion size and improves neurologic recovery in swine subjected to traumatic brain injury, hemorrhagic shock, and polytrauma.
Nikolian VC, Georgoff PE, Pai MP, Dennahy IS, Chtraklin K, Eidy H, Ghandour MH, Han Y, Srinivasan A, Li Y, Alam HB.
Nikolian VC, et al.
J Trauma Acute Care Surg. 2017 Dec;83(6):1066-1073. doi: 10.1097/TA.0000000000001612.
J Trauma Acute Care Surg. 2017.
PMID: 28697014
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