Imidazo[1,2-a]quinazolines as novel, potent EGFR-TK inhibitors: Design, synthesis, bioactivity evaluation, and in silico studies.
Hasanvand Z, Oghabi Bakhshaiesh T, Peytam F, Firoozpour L, Hosseinzadeh E, Motahari R, Moghimi S, Nazeri E, Toolabi M, Momeni F, Bijanzadeh H, Khalaj A, Baratte B, Josselin B, Robert T, Bach S, Esmaeili R, Foroumadi A.
Hasanvand Z, et al.
Bioorg Chem. 2023 Apr;133:106383. doi: 10.1016/j.bioorg.2023.106383. Epub 2023 Jan 20.
Bioorg Chem. 2023.
PMID: 36764231
These imidazoquinazolines (18a and 18o, in particular) had great anti-proliferative activities with IC(50) values in the micromolar (M) range against PC3, HepG2, HeLa, and MDA-MB-231 comparing with Erlotinib as reference marketed drug. ...Afterwards, the kinase assay on th …
These imidazoquinazolines (18a and 18o, in particular) had great anti-proliferative activities with IC(50) values in the micromolar (M …