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910 results

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Page 1
Showing results for m losartan
Search for M Kosaryan instead (1 results)
Topical Losartan and Corticosteroid Additively Inhibit Corneal Stromal Myofibroblast Generation and Scarring Fibrosis After Alkali Burn Injury.
Sampaio LP, Hilgert GSL, Shiju TM, Santhiago MR, Wilson SE. Sampaio LP, et al. Transl Vis Sci Technol. 2022 Jul 8;11(7):9. doi: 10.1167/tvst.11.7.9. Transl Vis Sci Technol. 2022. PMID: 35819289 Free PMC article.
PURPOSE: To evaluate the efficacy of losartan and prednisolone acetate in inhibiting corneal scarring fibrosis after alkali burn injury in rabbits. ...Four corneas in each group were treated six times per day for 1 month with 50 L of (1) 0.8 mg/mL losartan in balanc …
PURPOSE: To evaluate the efficacy of losartan and prednisolone acetate in inhibiting corneal scarring fibrosis after alkali burn inju …
Efficacy and Safety of Chinese Herbal Medicine Compared With Losartan for Mild Essential Hypertension: A Randomized, Multicenter, Double-Blind, Noninferiority Trial.
Lai X, Dong Z, Wu S, Zhou X, Zhang G, Xiong S, Wu W, Cao R, Wang X, Hua Q, Du J, Fan J, Mao J, Jiang W, Yuan H, Chen Y, Xu Y, Li Z, Zhang J, Dong G, Zhen H, Ding R, Wu Z, Gao Y. Lai X, et al. Circ Cardiovasc Qual Outcomes. 2022 Mar;15(3):e007923. doi: 10.1161/CIRCOUTCOMES.121.007923. Epub 2022 Feb 2. Circ Cardiovasc Qual Outcomes. 2022. PMID: 35105177 Clinical Trial.
We aimed to compare the blood pressure (BP)-lowering efficacy and safety of SXC versus losartan in patients with essential hypertension. METHODS: In this multicenter, randomized, double-blind, noninferiority trial in China, patients 18 to 65 years of age with mild essentia …
We aimed to compare the blood pressure (BP)-lowering efficacy and safety of SXC versus losartan in patients with essential hypertensi …
Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models.
Datta M, Chatterjee S, Perez EM, Gritsch S, Roberge S, Duquette M, Chen IX, Naxerova K, Kumar AS, Ghosh M, Emblem KE, Ng MR, Ho WW, Kumar P, Krishnan S, Dong X, Speranza MC, Neagu MR, Iorgulescu JB, Huang RY, Youssef G, Reardon DA, Sharpe AH, Freeman GJ, Suvà ML, Xu L, Jain RK. Datta M, et al. Proc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2219199120. doi: 10.1073/pnas.2219199120. Epub 2023 Feb 1. Proc Natl Acad Sci U S A. 2023. PMID: 36724255 Free PMC article.
Used in lieu of immunosuppressive corticosteroids, the angiotensin receptor blocker losartan prevented this ICB-induced edema and reprogrammed the tumor microenvironment, curing 20% of mice which increased to 40% in combination with standard of care treatment. Using a bihe …
Used in lieu of immunosuppressive corticosteroids, the angiotensin receptor blocker losartan prevented this ICB-induced edema and rep …
Losartan in hospitalized patients with COVID-19 in North America: An individual participant data meta-analysis.
Di Stefano L, Ram M, Scharfstein DO, Li T, Khanal P, Baksh SN, McBee N, Bengtson CD, Gadomski A, Geriak M, Puskarich MA, Salathe MA, Schutte AE, Tignanelli CJ, Victory J, Bierer BE, Hanley DF, Freilich DA; Pandemic Response COVID-19 Research Collaboration Platform for ACEi/ARB Pooled Analyses. Di Stefano L, et al. Medicine (Baltimore). 2023 Jun 9;102(23):e33904. doi: 10.1097/MD.0000000000033904. Medicine (Baltimore). 2023. PMID: 37335665 Free PMC article.
Losartan had worse effects for those taking corticosteroids at baseline after adjusting for covariates (ratio of adjusted ORs 0.29, 95% CrI 0.08-0.99). Hypotension serious adverse event rates were numerically higher with losartan. CONCLUSIONS: In this IPD meta-analy
Losartan had worse effects for those taking corticosteroids at baseline after adjusting for covariates (ratio of adjusted ORs 0.29, 9
Losartan may attenuate altitude-related sleep disturbance.
Clarke A, Ladha C, Wright A, Pattinson K; Birmingham Medical Research Expeditionary Society. Clarke A, et al. BMJ Mil Health. 2021 Dec;167(6):424-428. doi: 10.1136/jramc-2019-001308. Epub 2020 Feb 20. BMJ Mil Health. 2021. PMID: 32086272 Clinical Trial.
METHODS: Twenty participants paired by age, gender and ACE phenotype ascended to the Whymper Hut (5000 m) on Chimborazo in the Ecuadorean Andes as part of a double-blinded randomised placebo-controlled study of physiological mechanisms. Subjects were randomised to either …
METHODS: Twenty participants paired by age, gender and ACE phenotype ascended to the Whymper Hut (5000 m) on Chimborazo in the Ecuado …
Losartan Attenuates Scar Formation in Filtering Bleb After Trabeculectomy.
Shi H, Wang H, Fu S, Xu K, Zhang X, Xiao Y, Ye W. Shi H, et al. Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1478-1486. doi: 10.1167/iovs.16-21163. Invest Ophthalmol Vis Sci. 2017. PMID: 28273314
PURPOSE: To examine the effects of losartan on scar formation after trabeculectomy and on fibrotic changes of human Tenon's fibroblasts (HTFs). ...Immunostaining results showed less myofibroblast and collagen deposition around the bleb area in the losartan-treated e …
PURPOSE: To examine the effects of losartan on scar formation after trabeculectomy and on fibrotic changes of human Tenon's fibroblas …
Drug-drug interaction of losartan and glimepiride metabolism by recombinant microsome CYP2C9*1, 2C9*3, 2C9*13, and 2C9*16 in vitro.
Chen SZ, Pan PP, Shen LB, Xu SS, Dai DP, Geng PW, Cai J, Cai JP, Hu GX. Chen SZ, et al. Int J Clin Pharmacol Ther. 2014 Sep;52(9):732-8. doi: 10.5414/CP202071. Int J Clin Pharmacol Ther. 2014. PMID: 24986093
RESULTS: Metabolism of losartan by recombinant CYP2C9* 1, CYP2C9*3, CYP2C9*13, and CYP2C9* 16 was inhibited by glimepiride competitively with IC50 values of 0.669 0.055 M, 0.424 0.032 M, 2.557 0.058 M, and 0.667 0.039 M, respectively. ...The pot …
RESULTS: Metabolism of losartan by recombinant CYP2C9* 1, CYP2C9*3, CYP2C9*13, and CYP2C9* 16 was inhibited by glimepiride competitiv …
Losartan treatment attenuates tumor-induced myocardial dysfunction.
Stevens SC, Velten M, Youtz DJ, Clark Y, Jing R, Reiser PJ, Bicer S, Devine RD, McCarthy DO, Wold LE. Stevens SC, et al. J Mol Cell Cardiol. 2015 Aug;85:37-47. doi: 10.1016/j.yjmcc.2015.05.007. Epub 2015 May 16. J Mol Cell Cardiol. 2015. PMID: 25988231 Free PMC article.
Losartan treatment prevented tumor-induced loss of muscle mass and in vitro c26 cell proliferation, decreased tumor weight, and attenuated myocardial expression of interleukin-6. ...CONCLUSIONS: These data suggest that Losartan may mitigate tumor-induced myocardial
Losartan treatment prevented tumor-induced loss of muscle mass and in vitro c26 cell proliferation, decreased tumor weight, and atten
Losartan sensitizes selectively prostate cancer cell to ionizing radiation.
Yazdannejat H, Hosseinimehr SJ, Ghasemi A, Pourfallah TA, Rafiei A. Yazdannejat H, et al. Cell Mol Biol (Noisy-le-grand). 2016 Jan 11;62(1):30-3. Cell Mol Biol (Noisy-le-grand). 2016. PMID: 26828983
The cell proliferation was determined using MTT assay. Our results showed that losartan exhibited antitumor effect on prostate cancer cells; it was reduced cell survival to 66% at concentration 1 M. ...The cell proliferation was reduced to 54% in the prostate cancer …
The cell proliferation was determined using MTT assay. Our results showed that losartan exhibited antitumor effect on prostate cancer …
Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells.
Gu L, Zhu Y, Lee M, Nguyen A, Ryujin NT, Huang JY, Pandit SK, Chamseddine S, Xiao L, Mohamed YI, Kaseb AO, Karin M, Shalapour S. Gu L, et al. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2300706120. doi: 10.1073/pnas.2300706120. Epub 2023 May 1. Proc Natl Acad Sci U S A. 2023. PMID: 37126700 Free PMC article.
Although losartan did not potentiate T cell reinvigoration, it substantially enhanced HCC infiltration by effector CD8(+) T cells compared to PD-1 blockade alone. The beneficial effects of losartan correlated with blunted TGF-beta receptor signaling, reduced collage …
Although losartan did not potentiate T cell reinvigoration, it substantially enhanced HCC infiltration by effector CD8(+) T cells com …
910 results