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Page 1
Moringa oleifera and Its Biochemical Compounds: Potential Multi-targeted Therapeutic Agents Against COVID-19 and Associated Cancer Progression.
Yousefi Rad A, Rastegari AA, Shahanipour K, Monajemi R. Yousefi Rad A, et al. Biochem Genet. 2024 Apr 7. doi: 10.1007/s10528-024-10758-w. Online ahead of print. Biochem Genet. 2024. PMID: 38583096 Review.
Overall, this review highlights the potential therapeutic benefits of M. oleifera in addressing COVID-19 and associated cancer progression. However, further investigations are necessary to fully understand the cellular and molecular mechanisms of action of M. oleife …
Overall, this review highlights the potential therapeutic benefits of M. oleifera in addressing COVID-19 and associated cancer progre …
Novel N-benzylpiperidine derivatives of 5-arylisoxazole-3-carboxamides as anti-Alzheimer's agents.
Saeedi M, Felegari P, Iraji A, Hariri R, Rastegari A, Mirfazli SS, Edraki N, Firuzi O, Mahdavi M, Akbarzadeh T. Saeedi M, et al. Arch Pharm (Weinheim). 2021 Mar;354(3):e2000258. doi: 10.1002/ardp.202000258. Epub 2020 Nov 23. Arch Pharm (Weinheim). 2021. PMID: 33226157
The neuroprotective assessment revealed that 4e exhibited 23.2% protection at 50 M toward amyloid-beta-induced PC12 neuronal cells. Overall, this study exhibited that compound 4e was a promising compound targeting multiple factors associated with AD....
The neuroprotective assessment revealed that 4e exhibited 23.2% protection at 50 M toward amyloid-beta-induced PC12 neuronal cells. O …
Methods to Estimate the Average Social Network Size.
Baneshi MR, Haji-Maghsoudi S, Rastegari A, Mirzazadeh A. Baneshi MR, et al. Adv Exp Med Biol. 2021;1333:17-37. doi: 10.1007/978-3-030-75464-8_2. Adv Exp Med Biol. 2021. PMID: 34339009
Novel tacrine-based acetylcholinesterase inhibitors as potential agents for the treatment of Alzheimer's disease: Quinolotacrine hybrids.
Sadafi Kohnehshahri M, Chehardoli G, Bahiraei M, Akbarzadeh T, Ranjbar A, Rastegari A, Najafi Z. Sadafi Kohnehshahri M, et al. Mol Divers. 2022 Feb;26(1):489-503. doi: 10.1007/s11030-021-10307-2. Epub 2021 Sep 7. Mol Divers. 2022. PMID: 34491490
The designed derivatives indicated higher inhibitory effect on the acetylcholinesterase (AChE) with IC(50) values of 0.285-100 M compared to butyrylcholinesterase (BChE) with IC(50) values of > 100 M. ...The kinetic and molecular docking studies illustrated that …
The designed derivatives indicated higher inhibitory effect on the acetylcholinesterase (AChE) with IC(50) values of 0.285-100 M comp …
Phytochemical analysis and anticholinesterase activity of aril of Myristica fragrans Houtt.
Rastegari A, Manayi A, Rezakazemi M, Eftekhari M, Khanavi M, Akbarzadeh T, Saeedi M. Rastegari A, et al. BMC Chem. 2022 Nov 28;16(1):106. doi: 10.1186/s13065-022-00897-9. BMC Chem. 2022. PMID: 36437466 Free PMC article.
The phytochemical study led to isolation and identification of malabaricone A (1), malabaricone C (2), 4-(4-(3,4-dimethoxyphenyl)-2,3-dimethylbutyl)benzene-1,2-diol (3), nectandrin B (4), macelignan (5), and 4-(4-(benzo[d][1,3]dioxol-5-yl)-1-methoxy-2,3-dimethylbutyl)-2-methoxyph …
The phytochemical study led to isolation and identification of malabaricone A (1), malabaricone C (2), 4-(4-(3,4-dimethoxyphenyl)-2,3-dimeth …
Phytochemical investigation and anticholinesterase activity of ethyl acetate fraction of Myristica fragrans Houtt. seeds.
Omidpanah S, Vahedi-Mazdabadi Y, Manayi A, Rastegari A, Hariri R, Mortazavi-Ardestani E, Eftekhari M, Khanavi M, Akbarzadeh T, Saeedi M. Omidpanah S, et al. Nat Prod Res. 2022 Jan;36(2):610-616. doi: 10.1080/14786419.2020.1788555. Epub 2020 Jul 8. Nat Prod Res. 2022. PMID: 32640862
Our results confirmed the presence of trimyristin and 5,7-diacetyl chrysin (reported for the first time in M. fragrans) in the corresponding fraction....
Our results confirmed the presence of trimyristin and 5,7-diacetyl chrysin (reported for the first time in M. fragrans) in the corres …
Design, synthesis and anti-Alzheimer's activity of novel 1,2,3-triazole-chromenone carboxamide derivatives.
Rastegari A, Nadri H, Mahdavi M, Moradi A, Mirfazli SS, Edraki N, Moghadam FH, Larijani B, Akbarzadeh T, Saeedi M. Rastegari A, et al. Bioorg Chem. 2019 Mar;83:391-401. doi: 10.1016/j.bioorg.2018.10.065. Epub 2018 Oct 30. Bioorg Chem. 2019. PMID: 30412794
Among them, N-(1-benzylpiperidin-4-yl)-7-((1-(3,4-dimethylbenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-2-oxo-2H-chromene-3-carboxamide (11b) showed the best acetylcholinesterase inhibitory activity (IC(50) = 1.80 M), however, it was inactive toward butyrylcholinesterase. It shou …
Among them, N-(1-benzylpiperidin-4-yl)-7-((1-(3,4-dimethylbenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-2-oxo-2H-chromene-3-carboxamide (11b) showe …
Enzyme-responsive mannose-grafted magnetic nanoparticles for breast and liver cancer therapy and tumor-associated macrophage immunomodulation.
Darya GH, Zare O, Karbalaei-Heidari HR, Zeinali S, Sheardown H, Rastegari B. Darya GH, et al. Expert Opin Drug Deliv. 2024 Apr;21(4):663-677. doi: 10.1080/17425247.2024.2347300. Epub 2024 May 6. Expert Opin Drug Deliv. 2024. PMID: 38680108
Furthermore, the expression levels of IL-6 and ARG-1 after treatment with PG and PG@M-MNPs on M1 and M2 macrophage subsets were studied. RESULTS: The M-MNPs were successfully synthesized and characterized, demonstrating a size below 100 nm. The release kinetics of P …
Furthermore, the expression levels of IL-6 and ARG-1 after treatment with PG and PG@M-MNPs on M1 and M2 macrophage subsets were studi …
Synthesis, characterization, DNA binding, cleavage activity, cytotoxicity and molecular docking of new nano water-soluble [M(5-CH2PPh3-3,4-salpyr)](ClO4)2 (M = Ni, Zn) complexes.
Mandegani Z, Asadi Z, Asadi M, Karbalaei-Heidari HR, Rastegari B. Mandegani Z, et al. Dalton Trans. 2016 Apr 21;45(15):6592-611. doi: 10.1039/c5dt04788a. Dalton Trans. 2016. PMID: 26961248
Some new water soluble complexes [N,N'-bis{5-[(triphenyl phosphonium chloride)-methyl]salicylidine}-3,4-diaminopyridine] M(ii), which are formulated as nano-[Zn(5-CH2PPh3-3,4-salpyr)](ClO4)2 (), [Zn(5-CH2PPh3-3,4-salpyr)](ClO4)2 (), nano-[Ni(5-CH2PPh3-3,4-salpyr)](ClO4)2 ( …
Some new water soluble complexes [N,N'-bis{5-[(triphenyl phosphonium chloride)-methyl]salicylidine}-3,4-diaminopyridine] M(ii), which …
16 results