Discovery of new anticancer thiourea-azetidine hybrids: design, synthesis, in vitro antiproliferative, SAR, in silico molecular docking against VEGFR-2, ADMET, toxicity, and DFT studies.
Parmar DR, Soni JY, Guduru R, Rayani RH, Kusurkar RV, Vala AG, Talukdar SN, Eissa IH, Metwaly AM, Khalil A, Zunjar V, Battula S.
Parmar DR, et al.
Bioorg Chem. 2021 Oct;115:105206. doi: 10.1016/j.bioorg.2021.105206. Epub 2021 Jul 27.
Bioorg Chem. 2021.
PMID: 34339975
All the synthesized compounds were evaluated for their in vitro anticancer activity against various human cancer cell lines (lung (A549), prostate (PC3), breast (MCF-7), liver (HepG2), colon (HCT-116), ovarian (SKOV-3), skin (A431), brain (U251) and kidney (786-O)). 3-(4-Methoxy- …
All the synthesized compounds were evaluated for their in vitro anticancer activity against various human cancer cell lines (lung (A549), pr …