Liposomal aggregates sustain the release of rapamycin and protect cartilage from friction.
Bordon G, Ramakrishna SN, Edalat SG, Eugster R, Arcifa A, Vermathen M, Aleandri S, Bertoncelj MF, Furrer J, Vermathen P, Isa L, Crockett R, Distler O, Luciani P.
Bordon G, et al.
J Colloid Interface Sci. 2023 Nov 15;650(Pt B):1659-1670. doi: 10.1016/j.jcis.2023.07.087. Epub 2023 Jul 16.
J Colloid Interface Sci. 2023.
PMID: 37494862
Free article.
The aggregates extended RAPA release beyond free liposomes and displayed irregular morphology influenced by RAPA. At nearly 100 m, the aggregates were large enough to exceed the previously reported size threshold for increased joint retention. ...
The aggregates extended RAPA release beyond free liposomes and displayed irregular morphology influenced by RAPA. At nearly 100 m, th …