Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity.
Freedman BR, Kuttler A, Beckmann N, Nam S, Kent D, Schuleit M, Ramazani F, Accart N, Rock A, Li J, Kurz M, Fisch A, Ullrich T, Hast MW, Tinguely Y, Weber E, Mooney DJ.
Freedman BR, et al.
Nat Biomed Eng. 2022 Oct;6(10):1167-1179. doi: 10.1038/s41551-021-00810-0. Epub 2022 Jan 3.
Nat Biomed Eng. 2022.
PMID: 34980903
Free PMC article.
Here we report that a hydrogel serving as a high-capacity drug depot and combining a dissipative tough matrix on one side and a chitosan adhesive surface on the other side supports tendon gliding and strong adhesion (larger than 1,000 J m(-2)) to tendon on opposite surface …
Here we report that a hydrogel serving as a high-capacity drug depot and combining a dissipative tough matrix on one side and a chitosan adh …