Accurate computational design of three-dimensional protein crystals.
Li Z, Wang S, Nattermann U, Bera AK, Borst AJ, Yaman MY, Bick MJ, Yang EC, Sheffler W, Lee B, Seifert S, Hura GL, Nguyen H, Kang A, Dalal R, Lubner JM, Hsia Y, Haddox H, Courbet A, Dowling Q, Miranda M, Favor A, Etemadi A, Edman NI, Yang W, Weidle C, Sankaran B, Negahdari B, Ross MB, Ginger DS, Baker D.
Li Z, et al.
Nat Mater. 2023 Dec;22(12):1556-1563. doi: 10.1038/s41563-023-01683-1. Epub 2023 Oct 16.
Nat Mater. 2023.
PMID: 37845322
We design three pairs of oligomers that can be individually purified, and upon mixing, spontaneously self-assemble into >100 m three-dimensional crystals. The structures of these crystals are nearly identical to the computational design models, closely corresponding in …
We design three pairs of oligomers that can be individually purified, and upon mixing, spontaneously self-assemble into >100 m thr …