Thioquinoline derivatives conjugated to thiosemicarbazide as potent tyrosinase inhibitors with anti-melanogenesis properties.
Noori M, Sabourian R, Tasharoie A, Safavi M, Iraji A, Khalili Ghomi M, Dastyafteh N, Irajie C, Zarenezhad E, Mostafavi Pour SM, Rasekh F, Larijani B, Amini M, Hajimahmoodi M, Mahdavi M.
Noori M, et al.
Sci Rep. 2023 Feb 13;13(1):2578. doi: 10.1038/s41598-023-28852-1.
Sci Rep. 2023.
PMID: 36782003
Free PMC article.
Among the synthesized derivatives, compound 10g bearing para-chlorophenyl moiety was proved to be the most potent tyrosinase inhibitor with an IC(50) value of 25.75 0.19 M. Compound 10g as the most potent derivative exhibited a noncompetitive inhibition pattern against tyr …
Among the synthesized derivatives, compound 10g bearing para-chlorophenyl moiety was proved to be the most potent tyrosinase inhibitor with …