Increased Wnt levels in the neural tube impair the function of adherens junctions during neurulation.
Shariatmadari M, Peyronnet J, Papachristou P, Horn Z, Sousa KM, Arenas E, Ringstedt T.
Shariatmadari M, et al.
Mol Cell Neurosci. 2005 Nov;30(3):437-51. doi: 10.1016/j.mcn.2005.08.008. Epub 2005 Sep 9.
Mol Cell Neurosci. 2005.
PMID: 16154760
Surprisingly, transgenic embryos failed to complete cranial neurulation due to reduced levels and an impaired distribution of actin microfilaments, beta-catenin, and N-cadherin at the neural tube adherens junctions. These transgenic embryos expressed high levels of Vangl2, …
Surprisingly, transgenic embryos failed to complete cranial neurulation due to reduced levels and an impaired distribution of actin microfil …