Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1988 1
1990 1
1994 1
1995 2
1996 1
1997 2
1998 2
2000 3
2001 3
2002 2
2003 6
2004 3
2005 4
2006 7
2007 10
2008 6
2009 8
2010 9
2011 19
2012 11
2013 12
2014 11
2015 15
2016 19
2017 20
2018 29
2019 34
2020 35
2021 42
2022 30
2023 25
2024 11

Text availability

Article attribute

Article type

Publication date

Search Results

336 results

Results by year

Filters applied: . Clear all
Page 1
Chromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation.
Lee SC, Adams DW, Ipsaro JJ, Cahn J, Lynn J, Kim HS, Berube B, Major V, Calarco JP, LeBlanc C, Bhattacharjee S, Ramu U, Grimanelli D, Jacob Y, Voigt P, Joshua-Tor L, Martienssen RA. Lee SC, et al. Cell. 2023 Sep 14;186(19):4100-4116.e15. doi: 10.1016/j.cell.2023.08.001. Epub 2023 Aug 28. Cell. 2023. PMID: 37643610 Free PMC article.
In ddm1 mutants, DNA methylation is partly restored by loss of the H3.3 chaperone HIRA, while the H3.1 chaperone CAF-1 becomes essential. The single-particle cryo-EM structure at 3.2 A of DDM1 with a variant nucleosome reveals engagement with histone H3.3 near residues req …
In ddm1 mutants, DNA methylation is partly restored by loss of the H3.3 chaperone HIRA, while the H3.1 chaperone CAF-1 becomes essent …
Epidemiology of mucopolysaccharidoses.
Khan SA, Peracha H, Ballhausen D, Wiesbauer A, Rohrbach M, Gautschi M, Mason RW, Giugliani R, Suzuki Y, Orii KE, Orii T, Tomatsu S. Khan SA, et al. Mol Genet Metab. 2017 Jul;121(3):227-240. doi: 10.1016/j.ymgme.2017.05.016. Epub 2017 May 26. Mol Genet Metab. 2017. PMID: 28595941 Free PMC article.
Pneumonitis in Patients Treated With Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy.
Naidoo J, Wang X, Woo KM, Iyriboz T, Halpenny D, Cunningham J, Chaft JE, Segal NH, Callahan MK, Lesokhin AM, Rosenberg J, Voss MH, Rudin CM, Rizvi H, Hou X, Rodriguez K, Albano M, Gordon RA, Leduc C, Rekhtman N, Harris B, Menzies AM, Guminski AD, Carlino MS, Kong BY, Wolchok JD, Postow MA, Long GV, Hellmann MD. Naidoo J, et al. J Clin Oncol. 2017 Mar;35(7):709-717. doi: 10.1200/JCO.2016.68.2005. Epub 2016 Sep 30. J Clin Oncol. 2017. PMID: 27646942 Free PMC article.
Five patients worsened clinically and died during the course of pneumonitis treatment; proximal cause of death was pneumonitis (n = 1), infection related to immunosuppression (n = 3), or progressive cancer (n = 1). ...
Five patients worsened clinically and died during the course of pneumonitis treatment; proximal cause of death was pneumonitis (n = 1 …
HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers.
Morozov VM, Riva A, Sarwar S, Kim WJ, Li J, Zhou L, Licht JD, Daaka Y, Ishov AM. Morozov VM, et al. Nucleic Acids Res. 2023 Oct 27;51(19):10194-10217. doi: 10.1093/nar/gkad700. Nucleic Acids Res. 2023. PMID: 37638746 Free PMC article.
Expression of HIRA complex proteins is increased in PC compared with normal prostate tissue, especially in high-risk PC groups, and is associated with a negative prognosis. Collectively, our results demonstrate function of HIRA-dependent H3.3 pathway in regulation o …
Expression of HIRA complex proteins is increased in PC compared with normal prostate tissue, especially in high-risk PC groups, and i …
O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence.
Lee JS, Zhang Z. Lee JS, et al. Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):E3213-20. doi: 10.1073/pnas.1600509113. Epub 2016 May 23. Proc Natl Acad Sci U S A. 2016. PMID: 27217568 Free PMC article.
Here, we show that O-linked N-acetylglucosamine (GlcNAc) transferase (OGT), an enzyme that catalyzes O-GlcNAcylation of serine or threonine residues, interacts with UBN1, modifies HIRA, and promotes nucleosome assembly of H3.3. Depletion of OGT or expression of the …
Here, we show that O-linked N-acetylglucosamine (GlcNAc) transferase (OGT), an enzyme that catalyzes O-GlcNAcylation of serine or thr …
Autonomic Manifestations of Long-COVID Syndrome.
Hira R, Karalasingham K, Baker JR, Raj SR. Hira R, et al. Curr Neurol Neurosci Rep. 2023 Dec;23(12):881-892. doi: 10.1007/s11910-023-01320-z. Epub 2023 Nov 10. Curr Neurol Neurosci Rep. 2023. PMID: 37947962 Review.
Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation.
Gou LT, Lim DH, Ma W, Aubol BE, Hao Y, Wang X, Zhao J, Liang Z, Shao C, Zhang X, Meng F, Li H, Zhang X, Xu R, Li D, Rosenfeld MG, Mellon PL, Adams JA, Liu MF, Fu XD. Gou LT, et al. Cell. 2020 Mar 19;180(6):1212-1227.e14. doi: 10.1016/j.cell.2020.02.020. Epub 2020 Mar 12. Cell. 2020. PMID: 32169215 Free PMC article.
Interestingly, protamine undergoes a DNA-dependent phase transition to gel-like condensates and SRPK1-mediated phosphorylation likely helps open up such structures to enhance protamine dismissal by nucleoplasmin (NPM2) and enable the recruitment of HIRA for H3.3 deposition …
Interestingly, protamine undergoes a DNA-dependent phase transition to gel-like condensates and SRPK1-mediated phosphorylation likely helps …
Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via beta-catenin.
Li Y, Jiao J. Li Y, et al. J Cell Biol. 2017 Jul 3;216(7):1975-1992. doi: 10.1083/jcb.201610014. Epub 2017 May 17. J Cell Biol. 2017. PMID: 28515277 Free PMC article.
Histone cell cycle regulator (HIRA) is a histone chaperone and has been identified as an epigenetic regulator. ...Significantly, overexpression of HIRA, HIRA N-terminal domain, or beta-catenin can override neurogenesis abnormities caused by HIRA …
Histone cell cycle regulator (HIRA) is a histone chaperone and has been identified as an epigenetic regulator. ...Significantly, over …
The H3.3 chaperone Hira complex orchestrates oocyte developmental competence.
Smith R, Susor A, Ming H, Tait J, Conti M, Jiang Z, Lin CJ. Smith R, et al. Development. 2022 Mar 1;149(5):dev200044. doi: 10.1242/dev.200044. Epub 2022 Feb 28. Development. 2022. PMID: 35112132 Free PMC article.
Histone marks, including H3K4me3 and H3K9me3, are reduced and chromatin accessibility is impaired in Hira/Cabin1 mutants. Misregulated genes in mutant oocytes include Zscan4d, a two-cell specific gene involved in zygote genome activation. ...Thus, the H3.3 chaperone Hir …
Histone marks, including H3K4me3 and H3K9me3, are reduced and chromatin accessibility is impaired in Hira/Cabin1 mutants. Misregulate …
N-terminus of Etanercept is Proteolytically Processed by Dipeptidyl Peptidase-4.
Masui S, Yonezawa A, Yokoyama K, Iwamoto N, Shimada T, Onishi A, Onizawa H, Fujii T, Murakami K, Murata K, Tanaka M, Nakagawa S, Hira D, Itohara K, Imai S, Nakagawa T, Hayakari M, Matsuda S, Morinobu A, Terada T, Matsubara K. Masui S, et al. Pharm Res. 2022 Oct;39(10):2541-2554. doi: 10.1007/s11095-022-03371-2. Epub 2022 Aug 19. Pharm Res. 2022. PMID: 35986123
RESULTS: In the formulations, about 90% of ETN had an intact N-terminus, while the N-terminal truncated form was most abundant in the serum of the patients with rheumatoid arthritis and mice. Recombinant human DPP-4 cleaved two amino acids from the N-terminus …
RESULTS: In the formulations, about 90% of ETN had an intact N-terminus, while the N-terminal truncated form was most abundant …
336 results