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Whole genome sequencing analysis demonstrates therapy-induced echinocandin resistance in Candida auris isolates.
Spruijtenburg B, Ahmad S, Asadzadeh M, Alfouzan W, Al-Obaid I, Mokaddas E, Meijer EFJ, Meis JF, de Groot T. Spruijtenburg B, et al. Mycoses. 2023 Dec;66(12):1079-1086. doi: 10.1111/myc.13655. Epub 2023 Sep 15. Mycoses. 2023. PMID: 37712885
To determine whether the development of echinocandin resistance was due to independent introductions of resistant strains or resulted from intra-patient resistance development, whole genome sequencing (WGS) single-nucleotide polymorphism (SNP) analysis was performed on susceptibl …
To determine whether the development of echinocandin resistance was due to independent introductions of resistant strains or resulted from i …
Epidemiology of Candidemia in Kuwait: A Nationwide, Population-Based Study.
Alobaid K, Ahmad S, Asadzadeh M, Mokaddas E, Al-Sweih N, Albenwan K, Alfouzan W, Al-Obaid I, Jeragh A, Al-Roomi E, Khan Z, Joseph L, Varghese S. Alobaid K, et al. J Fungi (Basel). 2021 Aug 20;7(8):673. doi: 10.3390/jof7080673. J Fungi (Basel). 2021. PMID: 34436212 Free PMC article.
Mixed-species candidemia and re-infection occurred in 5 and 11 patients, respectively. C. albicans (n = 74), C. parapsilosis (n = 54), C. tropicalis (n = 35), C. auris (n = 33), C. glabrata (n = 32), other Candida spp. (n = 11), and other …
Mixed-species candidemia and re-infection occurred in 5 and 11 patients, respectively. C. albicans (n = 74), C. parapsilosis (n …
Molecular characterisation of Candida auris isolates from immunocompromised patients in a tertiary-care hospital in Kuwait reveals a novel mutation in FKS1 conferring reduced susceptibility to echinocandins.
Asadzadeh M, Mokaddas E, Ahmad S, Abdullah AA, de Groot T, Meis JF, Shetty SA. Asadzadeh M, et al. Mycoses. 2022 Mar;65(3):331-343. doi: 10.1111/myc.13419. Epub 2022 Jan 3. Mycoses. 2022. PMID: 34953089
This study analysed 49 C auris isolates for alterations in hotspot-1 and hotspot-2 of FKS1 for the detection of mutations conferring reduced susceptibility to echinocandins. METHODS: C auris isolates (n = 49) obtained from 18 immunocompromised patients during June 2016-Dec …
This study analysed 49 C auris isolates for alterations in hotspot-1 and hotspot-2 of FKS1 for the detection of mutations conferring reduced …
Evaluation of in vitro activity of ceftolozane/tazobactam and comparators against recent clinical bacterial isolates, and genomics of Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli isolates that demonstrated resistance to ceftolozane/tazobactam: data from Kuwait and Oman.
Alfouzan W, Dhar R, Mohsin J, Khamis F, Mokaddas E, Abdullah A, Mustafa AS, Otero A, Wanis P, Matar SH, Khalil S, Alekseeva I, Young K. Alfouzan W, et al. JAC Antimicrob Resist. 2022 Apr 21;4(2):dlac035. doi: 10.1093/jacamr/dlac035. eCollection 2022 Apr. JAC Antimicrob Resist. 2022. PMID: 35465239 Free PMC article.
METHODS: Ceftolozane/tazobactam and 14 comparators (amikacin, aztreonam, cefepime, cefotaxime, cefoxitin, ceftazidime, ceftriaxone, ciprofloxacin, colistin, ertapenem, imipenem, levofloxacin, meropenem and piperacillin/tazobactam) were evaluated against Pseudomonas aeruginosa and …
METHODS: Ceftolozane/tazobactam and 14 comparators (amikacin, aztreonam, cefepime, cefotaxime, cefoxitin, ceftazidime, ceftriaxone, ciproflo …
Performance Comparison of GeneXpert MTB/RIF and ProbeTec ET Tests for Rapid Molecular Diagnosis of Extrapulmonary Tuberculosis in a Low TB/MDR-TB Incidence Country.
Mokaddas E, Ahmad S, Eldeen H. Mokaddas E, et al. Med Princ Pract. 2021;30(3):277-284. doi: 10.1159/000515254. Epub 2021 Feb 16. Med Princ Pract. 2021. PMID: 33592621 Free PMC article.
MATERIALS AND METHODS: We tested nonrespiratory clinical specimens (n = 3,995) collected from 3,995 patients suspected to have EPTB. These included cavitary fluids (n = 2,054), fine-needle aspirate (FNA)/pus/tissue biopsy (n = 1,461), urine (n = 302), …
MATERIALS AND METHODS: We tested nonrespiratory clinical specimens (n = 3,995) collected from 3,995 patients suspected to have EPTB. …
First insights into the phylogenetic diversity of Mycobacterium tuberculosis in Kuwait and evaluation of REBA MTB-MDR assay for rapid detection of MDR-TB.
Al-Mutairi NM, Ahmad S, Mokaddas E, Al-Hajoj S. Al-Mutairi NM, et al. PLoS One. 2022 Oct 20;17(10):e0276487. doi: 10.1371/journal.pone.0276487. eCollection 2022. PLoS One. 2022. PMID: 36264939 Free PMC article.
This study investigated major Mtb genotypes circulating in Kuwait and evaluated the performance of REBA MTB-MDR (REBA) test in comparison to GenoType MTBDRplus (gMTBDR+) assay for rapid detection of resistance of Mtb to isoniazid and rifampicin (MDR-TB). M. tuberculosis isolates …
This study investigated major Mtb genotypes circulating in Kuwait and evaluated the performance of REBA MTB-MDR (REBA) test in comparison to …
Levels of (1→3)-β-D-glucan, Candida mannan and Candida DNA in serum samples of pediatric cancer patients colonized with Candida species.
Mokaddas E, Burhamah MH, Khan ZU, Ahmad S. Mokaddas E, et al. BMC Infect Dis. 2010 Oct 6;10:292. doi: 10.1186/1471-2334-10-292. BMC Infect Dis. 2010. PMID: 20923575 Free PMC article.
METHODS: A total of 1075 swabs originating from oropharynx (n = 294), nostrils (n = 600), rectum (n = 28), groin (n = 50), ear (n = 54), and axilla (n = 49) of 63 pediatric cancer patients were cultured for the isolation of Candida spp. . …
METHODS: A total of 1075 swabs originating from oropharynx (n = 294), nostrils (n = 600), rectum (n = 28), groin (n …
Invasive Candida auris infections in Kuwait hospitals: epidemiology, antifungal treatment and outcome.
Khan Z, Ahmad S, Benwan K, Purohit P, Al-Obaid I, Bafna R, Emara M, Mokaddas E, Abdullah AA, Al-Obaid K, Joseph L. Khan Z, et al. Infection. 2018 Oct;46(5):641-650. doi: 10.1007/s15010-018-1164-y. Epub 2018 Jun 14. Infection. 2018. PMID: 29949089
Despite antifungal treatment, 9 of 15 patients died. Most patients (n = 12) were hospitalized in 2 hospitals that are in close proximity, whereas 5 other patients were from 3 hospitals that are situated > 10 km apart. ...
Despite antifungal treatment, 9 of 15 patients died. Most patients (n = 12) were hospitalized in 2 hospitals that are in close proxim …
Molecular Screening Versus Phenotypic Susceptibility Testing of Multidrug-Resistant Mycobacterium tuberculosis Isolates for Streptomycin and Ethambutol.
Al-Mutairi NM, Ahmad S, Mokaddas E. Al-Mutairi NM, et al. Microb Drug Resist. 2018 Sep;24(7):923-931. doi: 10.1089/mdr.2017.0294. Epub 2018 Jan 16. Microb Drug Resist. 2018. PMID: 29336677
This study compared the performance of Mycobacterium Growth Indicator Tube (MGIT) 960 system for DST of MDR-TB isolates with polymerase chain reaction (PCR) sequencing of embB, rpsL, and rrs genes for detecting resistance to EMB and SM. MDR-TB strains (n = 60) and 25 pansu …
This study compared the performance of Mycobacterium Growth Indicator Tube (MGIT) 960 system for DST of MDR-TB isolates with polymerase chai …
Variations in the occurrence of specific rpoB mutations in rifampicin-resistant Mycobacterium tuberculosis isolates from patients of different ethnic groups in Kuwait.
Ahmad S, Al-Mutairi NM, Mokaddas E. Ahmad S, et al. Indian J Med Res. 2012 May;135(5):756-62. Indian J Med Res. 2012. PMID: 22771609 Free PMC article.
METHODS: Rifampicin-resistant M. tuberculosis isolates (n=119) from South Asian (n=55), Southeast Asian (n=23), Middle Eastern (n=39) and other (n=2) patients and 107 rifampicin-susceptible isolates were tested. ...Mutations among isolates from …
METHODS: Rifampicin-resistant M. tuberculosis isolates (n=119) from South Asian (n=55), Southeast Asian (n=23), Middle …
18 results