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Conflict of Interest Disclosures.
[No authors listed] [No authors listed] Global Spine J. 2023 May;13(2_suppl):568S-591S. doi: 10.1177/21925682231173597. Global Spine J. 2023. PMID: 37222100 Free PMC article. No abstract available.
Design of a mucin-selective protease for targeted degradation of cancer-associated mucins.
Pedram K, Shon DJ, Tender GS, Mantuano NR, Northey JJ, Metcalf KJ, Wisnovsky SP, Riley NM, Forcina GC, Malaker SA, Kuo A, George BM, Miller CL, Casey KM, Vilches-Moure JG, Ferracane MJ, Weaver VM, Läubli H, Bertozzi CR. Pedram K, et al. Nat Biotechnol. 2024 Apr;42(4):597-607. doi: 10.1038/s41587-023-01840-6. Epub 2023 Aug 3. Nat Biotechnol. 2024. PMID: 37537499 Free PMC article.
Here, to expand the landscape of targetable substrates, we designed degraders that achieve substrate selectivity via recognition of a discrete peptide and glycan motif and achieve cell-type selectivity via antigen-driven cell-surface binding. We applied this approach to mucins, …
Here, to expand the landscape of targetable substrates, we designed degraders that achieve substrate selectivity via recognition of a discre …
Revealing the human mucinome.
Malaker SA, Riley NM, Shon DJ, Pedram K, Krishnan V, Dorigo O, Bertozzi CR. Malaker SA, et al. Nat Commun. 2022 Jun 20;13(1):3542. doi: 10.1038/s41467-022-31062-4. Nat Commun. 2022. PMID: 35725833 Free PMC article.
Mucin domains are densely O-glycosylated modular protein domains found in various extracellular and transmembrane proteins. Mucin-domain glycoproteins play important roles in many human diseases, such as cancer and cystic fibrosis, but the scope of the mucinome remains poo …
Mucin domains are densely O-glycosylated modular protein domains found in various extracellular and transmembrane proteins. Mucin-dom …
Advances in nanomaterial-based immunosensors for prostate cancer screening.
Khan R, Arshad F, Hassan IU, Naikoo GA, Pedram MZ, Zedegan MS, Pourfarzad H, Aljabali AAA, Serrano-Aroca Á, Haggag Y, Mishra V, Mishra Y, Birkett M, Tambuwala MM. Khan R, et al. Biomed Pharmacother. 2022 Nov;155:113649. doi: 10.1016/j.biopha.2022.113649. Epub 2022 Sep 13. Biomed Pharmacother. 2022. PMID: 36108389 Free article. Review.
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals.
Pedram K, Laqtom NN, Shon DJ, Di Spiezio A, Riley NM, Saftig P, Abu-Remaileh M, Bertozzi CR. Pedram K, et al. Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2117105119. doi: 10.1073/pnas.2117105119. Epub 2022 Sep 19. Proc Natl Acad Sci U S A. 2022. PMID: 36122205 Free PMC article.
Here, we challenge this view by providing genetic and biochemical evidence supporting mammalian proteolysis of heavily O-glycosylated mucin domains without prior deglycosylation. Using activity screening coupled with mass spectrometry, we ascribed mucin-degrading activity …
Here, we challenge this view by providing genetic and biochemical evidence supporting mammalian proteolysis of heavily O-glycosylated …
Mitochondrial nitric oxide synthase, oxidative stress and apoptosis.
Ghafourifar P, Bringold U, Klein SD, Richter C. Ghafourifar P, et al. Biol Signals Recept. 2001 Jan-Apr;10(1-2):57-65. doi: 10.1159/000046875. Biol Signals Recept. 2001. PMID: 11223640 Review.
Nitric oxide (NO) exerts a wide range of its biological properties via its interaction with mitochondria. By competing with O(2), physiologically relevant concentrations of NO reversibly inhibit cytochrome oxidase and decrease O(2) consumption, in a manner resemblin …
Nitric oxide (NO) exerts a wide range of its biological properties via its interaction with mitochondria. By competing with O(2), phy …
Recent Advances in Anticancer Activity of Novel Plant Extracts and Compounds from Curcuma longa in Hepatocellular Carcinoma.
Gull N, Arshad F, Naikoo GA, Hassan IU, Pedram MZ, Ahmad A, Aljabali AAA, Mishra V, Satija S, Charbe N, Negi P, Goyal R, Serrano-Aroca Á, Al Zoubi MS, El-Tanani M, Tambuwala MM. Gull N, et al. J Gastrointest Cancer. 2023 Jun;54(2):368-390. doi: 10.1007/s12029-022-00809-z. Epub 2022 Mar 14. J Gastrointest Cancer. 2023. PMID: 35285010 Free PMC article. Review.
An enzymatic toolkit for selective proteolysis, detection, and visualization of mucin-domain glycoproteins.
Shon DJ, Malaker SA, Pedram K, Yang E, Krishnan V, Dorigo O, Bertozzi CR. Shon DJ, et al. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21299-21307. doi: 10.1073/pnas.2012196117. Epub 2020 Aug 17. Proc Natl Acad Sci U S A. 2020. PMID: 32817557 Free PMC article.
Densely O-glycosylated mucin domains are found in a broad range of cell surface and secreted proteins, where they play key physiological roles. ...
Densely O-glycosylated mucin domains are found in a broad range of cell surface and secreted proteins, where they play key physiologi …
29 results