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Functional characterization of the promoter of the human Lon protease gene.
Pinti M, Gibellini L, De Biasi S, Nasi M, Roat E, O'Connor JE, Cossarizza A. Pinti M, et al. Among authors: roat e. Mitochondrion. 2011 Jan;11(1):200-6. doi: 10.1016/j.mito.2010.09.010. Epub 2010 Oct 7. Mitochondrion. 2011. PMID: 20933102
Lon is upregulated in the presence of substances such as stavudine (d4T), D-deoxyribose (dRib), that increase the intracellular reactive oxygen species (ROS) levels, or in the presence of H(2)O(2.) Here we show the promoter region -623/+1 is essential for response to ROS, …
Lon is upregulated in the presence of substances such as stavudine (d4T), D-deoxyribose (dRib), that increase the intracellular reactive oxy …
Adipose differentiation-related protein regulates lipids and insulin in pancreatic islets.
Faleck DM, Ali K, Roat R, Graham MJ, Crooke RM, Battisti R, Garcia E, Ahima RS, Imai Y. Faleck DM, et al. Among authors: roat r. Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E249-57. doi: 10.1152/ajpendo.00646.2009. Epub 2010 May 18. Am J Physiol Endocrinol Metab. 2010. PMID: 20484013 Free PMC article.
The downregulation of ADFP in MIN6 cells by antisense oligonucleotide (ASO) suppressed the accumulation of triglycerides upon fatty acid loading (56% of control) along with a reduction in the mRNA levels of lipogenic genes such as diacylglycerol O-acyltransferase-2 and fat …
The downregulation of ADFP in MIN6 cells by antisense oligonucleotide (ASO) suppressed the accumulation of triglycerides upon fatty acid loa …
The attenuation of central angiotensin II-dependent pressor response and intra-neuronal signaling by intracarotid injection of nanoformulated copper/zinc superoxide dismutase.
Rosenbaugh EG, Roat JW, Gao L, Yang RF, Manickam DS, Yin JX, Schultz HD, Bronich TK, Batrakova EV, Kabanov AV, Zucker IH, Zimmerman MC. Rosenbaugh EG, et al. Among authors: roat jw. Biomaterials. 2010 Jul;31(19):5218-26. doi: 10.1016/j.biomaterials.2010.03.026. Epub 2010 Apr 7. Biomaterials. 2010. PMID: 20378166 Free PMC article.
Adenoviral-mediated overexpression of the intracellular superoxide (O(2)(*-)) scavenging enzyme copper/zinc superoxide dismutase (CuZnSOD) in the brain attenuates central angiotensin II (AngII)-induced cardiovascular responses. ...We hypothesized that PEI-PEG polymer incre …
Adenoviral-mediated overexpression of the intracellular superoxide (O(2)(*-)) scavenging enzyme copper/zinc superoxide dismutase (CuZ …
Essential requirement of reduced glutathione (GSH) for the anti-oxidant effect of the flavonoid quercetin.
Ferraresi R, Troiano L, Roat E, Lugli E, Nemes E, Nasi M, Pinti M, Fernandez MI, Cooper EL, Cossarizza A. Ferraresi R, et al. Among authors: roat e. Free Radic Res. 2005 Nov;39(11):1249-58. doi: 10.1080/10715760500306935. Free Radic Res. 2005. PMID: 16298752
We have analyzed the anti- or pro-oxidant effects of the flavonoid quercetin (QU) by evaluating, in U937 cell line, hydrogen peroxide (H(2)O(2)), superoxide anion reduced glutathione (GSH) content, mitochondrial membrane potential, DNA content, phosphatidylserine exposure …
We have analyzed the anti- or pro-oxidant effects of the flavonoid quercetin (QU) by evaluating, in U937 cell line, hydrogen peroxide (H(2) …