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Page 1
Mast Cell Purification Protocols.
Farrington J, Seward EP, Peachell PT. Farrington J, et al. Methods Mol Biol. 2020;2163:49-56. doi: 10.1007/978-1-0716-0696-4_3. Methods Mol Biol. 2020. PMID: 32766964
Regulation of mast cells by beta-agonists.
Peachell P. Peachell P. Clin Rev Allergy Immunol. 2006 Oct-Dec;31(2-3):131-42. doi: 10.1385/CRIAI:31:2:131. Clin Rev Allergy Immunol. 2006. PMID: 17085789 Review.
Targeting the mast cell in asthma.
Peachell P. Peachell P. Curr Opin Pharmacol. 2005 Jun;5(3):251-6. doi: 10.1016/j.coph.2005.03.001. Curr Opin Pharmacol. 2005. PMID: 15907911 Review.
Preclinical evaluation of an inhibitor of cytosolic phospholipase A2α for the treatment of asthma.
Hewson CA, Patel S, Calzetta L, Campwala H, Havard S, Luscombe E, Clarke PA, Peachell PT, Matera MG, Cazzola M, Page C, Abraham WM, Williams CM, Clark JD, Liu WL, Clarke NP, Yeadon M. Hewson CA, et al. J Pharmacol Exp Ther. 2012 Mar;340(3):656-65. doi: 10.1124/jpet.111.186379. Epub 2011 Dec 7. J Pharmacol Exp Ther. 2012. PMID: 22160268

In a sheep model of allergic inflammation, inhalation of PF-5212372 significantly inhibited late-phase bronchoconstriction (78% inhibition; p < 0.001) and airway hyper-responsiveness (94% inhibition; p < 0.001), and isolated sheep lung mast cell assays confirm

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In a sheep model of allergic inflammation, inhalation of PF-5212372 significantly inhibited late-phase bronchoconstriction (78% inhibition; …
Desensitisation of mast cell beta2-adrenoceptor-mediated responses by salmeterol and formoterol.
Scola AM, Chong LK, Suvarna SK, Chess-Williams R, Peachell PT. Scola AM, et al. Br J Pharmacol. 2004 Jan;141(1):163-71. doi: 10.1038/sj.bjp.0705599. Epub 2003 Dec 8. Br J Pharmacol. 2004. PMID: 14662724 Free PMC article.
Isoprenaline, formoterol and salmeterol (all at 10(-5) m) increased total cell cAMP levels in mast cells over basal by 361+/-90 (P<0.05), 321+/-89 (P<0.05) and 64+/-24% (P>0.05), respectively. 3. ...Isoprenaline, formoterol and salmeterol (all at 10( …
Isoprenaline, formoterol and salmeterol (all at 10(-5) m) increased total cell cAMP levels in mast cells over basal by 361+/-90 (P&lt …
Effects of phosphodiesterase inhibitors on human lung mast cell and basophil function.
Weston MC, Anderson N, Peachell PT. Weston MC, et al. Br J Pharmacol. 1997 May;121(2):287-95. doi: 10.1038/sj.bjp.0701115. Br J Pharmacol. 1997. PMID: 9154339 Free PMC article.

IBMX (100 microM) inhibited the PDE activity in basophil extracts by 67 +/- 7% (P < 0.0001) and in HLMC extracts by 63 +/- 9% (P < 0.0005). The hydrolysis of cyclic AMP by basophil extracts was inhibited by the selective PDE inhibitors (all at 10 microM), roli

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IBMX (100 microM) inhibited the PDE activity in basophil extracts by 67 +/- 7% (P < 0.0001) and in HLMC extracts by 63 +/- 9% (

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28 results