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Page 1
Role of endothelial microvesicles released by p-cresol on endothelial dysfunction.
Guerrero F, Carmona A, Obrero T, Jiménez MJ, Soriano S, Moreno JA, Martín-Malo A, Aljama P. Guerrero F, et al. Sci Rep. 2020 Jun 30;10(1):10657. doi: 10.1038/s41598-020-67574-6. Sci Rep. 2020. PMID: 32606426 Free PMC article.
Protein bound uremic toxins, such as p-cresol, cannot be effectively removed by conventional dialysis techniques and are accumulated in plasma, thus contributing to progression of both chronic kidney disease (CKD) and cardiovascular disease (CVD). Pathological effects of u …
Protein bound uremic toxins, such as p-cresol, cannot be effectively removed by conventional dialysis techniques and are accumulated …
Asbestos Exposure and Severity of COVID-19.
Granados G, Sáez-López M, Aljama C, Sampol J, Cruz MJ, Ferrer J, Se-Covid-Team. Granados G, et al. Int J Environ Res Public Health. 2022 Dec 6;19(23):16305. doi: 10.3390/ijerph192316305. Int J Environ Res Public Health. 2022. PMID: 36498378 Free PMC article.
Patients with occupational exposure to asbestos had a higher frequency of COVID-19 pneumonia requiring respiratory support (n = 52, 77.6%) than their unexposed peers (n = 139, 61.5%) (p = 0.015). Asbestos exposure was associated with COVID-19 severity in the univariate but …
Patients with occupational exposure to asbestos had a higher frequency of COVID-19 pneumonia requiring respiratory support (n = 52, 77.6%) t …
24-Hour Proteinuria Versus Spot Protein-Creatinine Ratio for Kidney Transplant Management in Clinical Practice.
Rodelo-Haad C, Esquivias-Motta E, Agüera ML, Aljama P, Rodríguez-Benot A. Rodelo-Haad C, et al. Transplant Proc. 2018 Mar;50(2):560-564. doi: 10.1016/j.transproceed.2017.09.071. Transplant Proc. 2018. PMID: 29579852
Spot protein-creatinine ratio (P/Cr) has become the alternative to 24h-P for proteinuria evaluation in many KT units. ...RESULTS: A total of 8,549 urine samples were analyzed from 472 patients in whom 24h-P and P/Cr were simultaneously measured. A sign …
Spot protein-creatinine ratio (P/Cr) has become the alternative to 24h-P for proteinuria evaluation in many KT units. ...RESUL …
Venetoclax for the treatment of translocation (11;14) AL amyloidosis.
Sidiqi MH, Al Saleh AS, Leung N, Jevremovic D, Aljama MA, Gonsalves WI, Buadi FK, Kourelis TV, Warsame R, Muchtar E, Hobbs MA, Lacy MQ, Dingli D, Go RS, Hayman SR, Rajkumar SV, Dispenzieri A, Gertz MA, Kumar SK, Fonseca R, Kapoor P. Sidiqi MH, et al. Blood Cancer J. 2020 May 11;10(5):55. doi: 10.1038/s41408-020-0321-6. Blood Cancer J. 2020. PMID: 32393733 Free PMC article. No abstract available.
Incorporating zeolitic-imidazolate framework-8 nanoparticles into kidney scaffolds: a first step towards innovative renal therapies.
Guerrero F, Pulido V, Hamad S, Aljama P, Martín-Malo A, Carrillo-Carrión C. Guerrero F, et al. Nanoscale. 2022 Dec 8;14(47):17543-17549. doi: 10.1039/d2nr04246k. Nanoscale. 2022. PMID: 36421023 Free article.
We demonstrate for the first time the potential of zeolitic-imidazolate framework-8 nanoparticles to be incorporated within a renal scaffold while retaining their ability to remove uremic toxins (mainly hydrophobic toxins like p-cresol) under flow conditions. This work may …
We demonstrate for the first time the potential of zeolitic-imidazolate framework-8 nanoparticles to be incorporated within a renal scaffold …
Passage Number-Induced Replicative Senescence Modulates the Endothelial Cell Response to Protein-Bound Uremic Toxins.
Guerrero F, Carmona A, Jimenez MJ, Obrero T, Pulido V, Moreno JA, Soriano S, Martín-Malo A, Aljama P. Guerrero F, et al. Toxins (Basel). 2021 Oct 19;13(10):738. doi: 10.3390/toxins13100738. Toxins (Basel). 2021. PMID: 34679030 Free PMC article.
The uremic toxins indoxyl sulfate (IS) and p-cresol (PC) accumulate in the plasma of chronic kidney disease (CKD) patients, causing accelerated endothelial aging, increased cardiovascular events and mortality. ...
The uremic toxins indoxyl sulfate (IS) and p-cresol (PC) accumulate in the plasma of chronic kidney disease (CKD) patients, causing a …
Endothelial microparticles mediate inflammation-induced vascular calcification.
Buendía P, Montes de Oca A, Madueño JA, Merino A, Martín-Malo A, Aljama P, Ramírez R, Rodríguez M, Carracedo J. Buendía P, et al. FASEB J. 2015 Jan;29(1):173-81. doi: 10.1096/fj.14-249706. Epub 2014 Oct 23. FASEB J. 2015. PMID: 25342130

Calcium content was greater in VSMCs exposed to EMPs from TNF-alpha-treated HUVECs than EMPs from nontreated HUVECs (3.56 0.57 vs. 1.48 0.56 g/mg protein; P < 0.05). The increase in calcification was accompanied by up-regulation of Cbfa1 (osteogenic transcription factor

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Calcium content was greater in VSMCs exposed to EMPs from TNF-alpha-treated HUVECs than EMPs from nontreated HUVECs (3.56 0.57 vs. 1.48 0.56 …
Prevalence and Survival of Cancer After Pancreas-Kidney Transplantation.
Pendón-Ruiz de Mier MV, Agüera ML, Navarro MD, Rodriguez-Benot A, Aljama P. Pendón-Ruiz de Mier MV, et al. Transplant Proc. 2018 Mar;50(2):669-672. doi: 10.1016/j.transproceed.2017.09.064. Transplant Proc. 2018. PMID: 29579884
Patient and grafts survivals were lower in recipients with tumor compared with recipients without tumor, but the difference was not statistically significant: renal graft survival was 80% vs 90% at 10 years (P = .86); and pancreatic graft survival was 45% vs 70% at 10 year …
Patient and grafts survivals were lower in recipients with tumor compared with recipients without tumor, but the difference was not statisti …
Outcomes in renal transplantation with expanded-criteria donors.
Martínez-Vaquera S, Navarro Cabello MD, López-Andreu M, Jurado JM, Haad CR, Salas RO, Benot AR, Hernández JP, Arista JC, Aljama P. Martínez-Vaquera S, et al. Transplant Proc. 2013;45(10):3595-8. doi: 10.1016/j.transproceed.2013.11.003. Transplant Proc. 2013. PMID: 24314969
However, there were differences in donor age (75 vs 67; P = .043), increased preimplantation biopsy score (6.8 1.3 vs 4.8 1.1; P = .041), and a higher percentage of cardiovascular disease (62.5% vs 43%; P = .038). Comparison of ECD and non-ECD grafts showed a …
However, there were differences in donor age (75 vs 67; P = .043), increased preimplantation biopsy score (6.8 1.3 vs 4.8 1.1; P …
Proton Pump Inhibitor Usage and the Risk of Mortality in Hemodialysis Patients.
de Francisco ALM, Varas J, Ramos R, Merello JI, Canaud B, Stuard S, Pascual J, Aljama P; Optimizing Results in Dialysis (ORD) group. de Francisco ALM, et al. Kidney Int Rep. 2017 Nov 10;3(2):374-384. doi: 10.1016/j.ekir.2017.11.001. eCollection 2018 Mar. Kidney Int Rep. 2017. PMID: 29725641 Free PMC article.

RESULTS: PPI use was associated with hypomagnesemia (Mg <1.8 mg/dl (0.75 mmol/l); odds ratio [OR] = 2.70, 95% confidence interval [CI] = 1.38-5.27, P < 0.01). The exposure to PPIs in the full patient cohort was identified as an independent predictor for all-cause mor

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RESULTS: PPI use was associated with hypomagnesemia (Mg <1.8 mg/dl (0.75 mmol/l); odds ratio [OR] = 2.70, 95% confidence interval [CI] = …
97 results