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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 2
1995 1
2000 1
2005 2
2006 3
2007 10
2008 9
2009 15
2010 25
2011 43
2012 33
2013 46
2014 58
2015 77
2016 85
2017 67
2018 66
2019 64
2020 80
2021 102
2022 93
2023 81
2024 28

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877 results

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Page 1
Sleep, major depressive disorder, and Alzheimer disease: A Mendelian randomization study.
Huang J, Zuber V, Matthews PM, Elliott P, Tzoulaki J, Dehghan A. Huang J, et al. Neurology. 2020 Oct 6;95(14):e1963-e1970. doi: 10.1212/WNL.0000000000010463. Epub 2020 Aug 19. Neurology. 2020. PMID: 32817390 Free PMC article.
RESULTS: We found that higher risk of AD was significantly associated with being a "morning person" (odds ratio [OR] 1.01, p = 0.001), shorter sleep duration (self-reported: beta = -0.006, p = 1.9 10(-4); accelerometer based: beta = -0.015, p = 6.9 10(-5)), l …
RESULTS: We found that higher risk of AD was significantly associated with being a "morning person" (odds ratio [OR] 1.01, p = 0.001) …
Inflammatory Diseases, Inflammatory Biomarkers, and Alzheimer Disease: An Observational Analysis and Mendelian Randomization.
Huang J, Su B, Karhunen V, Gill D, Zuber V, Ahola-Olli A, Palaniswamy S, Auvinen J, Herzig KH, Keinänen-Kiukaanniemi S, Salmi M, Jalkanen S, Lehtimäki T, Salomaa V, Raitakari OT, Matthews PM, Elliott P, Tsilidis KK, Jarvelin MR, Tzoulaki I, Dehghan A. Huang J, et al. Neurology. 2023 Feb 7;100(6):e568-e581. doi: 10.1212/WNL.0000000000201489. Epub 2022 Nov 16. Neurology. 2023. PMID: 36384659 Free PMC article.
RESULTS: Cox regression models using CPRD data showed that the overall incidence of AD was higher among patients with inflammatory bowel disease (hazard ratio [HR] 1.17; 95% CI 1.15-1.19; p = 2.1 10(-4)), other inflammatory polyarthropathies and systematic connective tissu …
RESULTS: Cox regression models using CPRD data showed that the overall incidence of AD was higher among patients with inflammatory bowel dis …
Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study.
Dehghan M, Mente A, Zhang X, Swaminathan S, Li W, Mohan V, Iqbal R, Kumar R, Wentzel-Viljoen E, Rosengren A, Amma LI, Avezum A, Chifamba J, Diaz R, Khatib R, Lear S, Lopez-Jaramillo P, Liu X, Gupta R, Mohammadifard N, Gao N, Oguz A, Ramli AS, Seron P, Sun Y, Szuba A, Tsolekile L, Wielgosz A, Yusuf R, Hussein Yusufali A, Teo KK, Rangarajan S, Dagenais G, Bangdiwala SI, Islam S, Anand SS, Yusuf S; Prospective Urban Rural Epidemiology (PURE) study investigators. Dehghan M, et al. Lancet. 2017 Nov 4;390(10107):2050-2062. doi: 10.1016/S0140-6736(17)32252-3. Epub 2017 Aug 29. Lancet. 2017. PMID: 28864332
Higher carbohydrate intake was associated with an increased risk of total mortality (highest [quintile 5] vs lowest quintile [quintile 1] category, HR 1.28 [95% CI 1.12-1.46], p(trend)=0.0001) but not with the risk of cardiovascular disease or cardiovascular disease mortal …
Higher carbohydrate intake was associated with an increased risk of total mortality (highest [quintile 5] vs lowest quintile [quintile 1] ca …
Operative vs Nonoperative Treatment of Acute Unstable Chest Wall Injuries: A Randomized Clinical Trial.
Dehghan N, Nauth A, Schemitsch E, Vicente M, Jenkinson R, Kreder H, McKee M; Canadian Orthopaedic Trauma Society and the Unstable Chest Wall RCT Study Investigators. Dehghan N, et al. JAMA Surg. 2022 Nov 1;157(11):983-990. doi: 10.1001/jamasurg.2022.4299. JAMA Surg. 2022. PMID: 36129720 Free PMC article.
Mean (SD) VFDs were 22.7 (7.5) days for the operative group and 20.6 (9.7) days for the nonoperative group (mean difference, 2.1 days; 95% CI, -0.3 to 4.5 days; P = .09). Mortality was significantly higher in the nonoperative group (6 [6%]) than in the operative group (0%; …
Mean (SD) VFDs were 22.7 (7.5) days for the operative group and 20.6 (9.7) days for the nonoperative group (mean difference, 2.1 days; 95% C …
Genetic analysis of over half a million people characterises C-reactive protein loci.
Said S, Pazoki R, Karhunen V, Võsa U, Ligthart S, Bodinier B, Koskeridis F, Welsh P, Alizadeh BZ, Chasman DI, Sattar N, Chadeau-Hyam M, Evangelou E, Jarvelin MR, Elliott P, Tzoulaki I, Dehghan A. Said S, et al. Nat Commun. 2022 Apr 22;13(1):2198. doi: 10.1038/s41467-022-29650-5. Nat Commun. 2022. PMID: 35459240 Free PMC article.
Gene-set analysis highlighted 42 gene sets associated with CRP levels (p 3.2 10(-6)) and tissue expression analysis indicated a strong association of CRP related genes with liver and whole blood gene expression. ...
Gene-set analysis highlighted 42 gene sets associated with CRP levels (p 3.2 10(-6)) and tissue expression analysis indicated a stron …
The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study.
Karhunen V, Gill D, Huang J, Bouras E, Malik R, Ponsford MJ, Ahola-Olli A, Papadopoulou A, Palaniswamy S, Sebert S, Wielscher M, Auvinen J, Veijola J, Herzig KH, Timonen M, Keinänen-Kiukaanniemi S, Dichgans M, Salmi M, Jalkanen S, Lehtimäki T, Salomaa V, Raitakari O, Jones SA, Hovingh GK, Tsilidis KK, Järvelin MR, Dehghan A. Karhunen V, et al. BMJ Med. 2023 Feb 14;2(1):e000157. doi: 10.1136/bmjmed-2022-000157. eCollection 2023. BMJ Med. 2023. PMID: 36936266 Free PMC article.
Evidence for causal relations (mendelian randomisation P<0.0011) were noted between circulating cytokines, including a key role of vascular endothelial growth factor on influencing the concentrations of 10 other cytokines. Both mendelian randomisation (P<0.05) …
Evidence for causal relations (mendelian randomisation P<0.0011) were noted between circulating cytokines, including a key role of …
Association of dairy intake with cardiovascular disease and mortality in 21 countries from five continents (PURE): a prospective cohort study.
Dehghan M, Mente A, Rangarajan S, Sheridan P, Mohan V, Iqbal R, Gupta R, Lear S, Wentzel-Viljoen E, Avezum A, Lopez-Jaramillo P, Mony P, Varma RP, Kumar R, Chifamba J, Alhabib KF, Mohammadifard N, Oguz A, Lanas F, Rozanska D, Bostrom KB, Yusoff K, Tsolkile LP, Dans A, Yusufali A, Orlandini A, Poirier P, Khatib R, Hu B, Wei L, Yin L, Deeraili A, Yeates K, Yusuf R, Ismail N, Mozaffarian D, Teo K, Anand SS, Yusuf S; Prospective Urban Rural Epidemiology (PURE) study investigators. Dehghan M, et al. Lancet. 2018 Nov 24;392(10161):2288-2297. doi: 10.1016/S0140-6736(18)31812-9. Epub 2018 Sep 11. Lancet. 2018. PMID: 30217460
Higher intake of total dairy (>2 servings per day compared with no intake) was associated with a lower risk of the composite outcome (HR 0.84, 95% CI 0.75-0.94; p(trend)=0.0004), total mortality (0.83, 0.72-0.96; p(trend)=0.0052), non-cardiovascular mortality (0. …
Higher intake of total dairy (>2 servings per day compared with no intake) was associated with a lower risk of the composite outcome (HR …
Association of egg intake with blood lipids, cardiovascular disease, and mortality in 177,000 people in 50 countries.
Dehghan M, Mente A, Rangarajan S, Mohan V, Lear S, Swaminathan S, Wielgosz A, Seron P, Avezum A, Lopez-Jaramillo P, Turbide G, Chifamba J, AlHabib KF, Mohammadifard N, Szuba A, Khatib R, Altuntas Y, Liu X, Iqbal R, Rosengren A, Yusuf R, Smuts M, Yusufali A, Li N, Diaz R, Yusoff K, Kaur M, Soman B, Ismail N, Gupta R, Dans A, Sheridan P, Teo K, Anand SS, Yusuf S. Dehghan M, et al. Am J Clin Nutr. 2020 Apr 1;111(4):795-803. doi: 10.1093/ajcn/nqz348. Am J Clin Nutr. 2020. PMID: 31965140 Free PMC article. Clinical Trial.
In the PURE study, after excluding those with history of CVD, higher intake of egg (7 egg/wk compared with <1 egg/wk intake) was not significantly associated with blood lipids, composite outcome (HR: 0.96; 95% CI: 0.89, 1.04; P-trend = 0.74), total mortality (HR: 1.04; …
In the PURE study, after excluding those with history of CVD, higher intake of egg (7 egg/wk compared with <1 egg/wk intake) was not sign …
Early Weightbearing and Range of Motion Versus Non-Weightbearing and Immobilization After Open Reduction and Internal Fixation of Unstable Ankle Fractures: A Randomized Controlled Trial.
Dehghan N, McKee MD, Jenkinson RJ, Schemitsch EH, Stas V, Nauth A, Hall JA, Stephen DJ, Kreder HJ. Dehghan N, et al. J Orthop Trauma. 2016 Jul;30(7):345-52. doi: 10.1097/BOT.0000000000000572. J Orthop Trauma. 2016. PMID: 27045369 Clinical Trial.

At 6 weeks postoperatively, patients in the Early WB group had significantly improved ankle ROM (41 vs. 29, P < 0.0001); Olerud/Molander ankle function scores (45 vs. 32, P = 0.0007), and SF-36 scores on both the physical (51 vs. 42, P = 0.008) and mental

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At 6 weeks postoperatively, patients in the Early WB group had significantly improved ankle ROM (41 vs. 29, P < 0.0001); Olerud/Mo

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Metabolome-wide association study on physical activity.
Kojouri M, Pinto R, Mustafa R, Huang J, Gao H, Elliott P, Tzoulaki I, Dehghan A. Kojouri M, et al. Sci Rep. 2023 Feb 9;13(1):2374. doi: 10.1038/s41598-022-26377-7. Sci Rep. 2023. PMID: 36759570 Free PMC article.

Mendelian randomisation was carried out to investigate potential causal associations between physical activity, body mass index, and metabolites. Higher vigorous physical activity was associated (P < 0.05/828 = 6.03 10(-5)) with circulatory levels of 28 metabolites adju

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Mendelian randomisation was carried out to investigate potential causal associations between physical activity, body mass index, and metabol …
877 results