Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1979 1
1986 1
1989 1
1991 1
1993 1
1997 1
1999 2
2000 2
2001 1
2002 1
2003 4
2004 4
2005 7
2006 8
2007 13
2008 5
2009 6
2010 14
2011 8
2012 15
2013 17
2014 26
2015 22
2016 20
2017 25
2018 25
2019 29
2020 20
2021 27
2022 25
2023 19
2024 5

Text availability

Article attribute

Article type

Publication date

Search Results

311 results

Results by year

Filters applied: . Clear all
Page 1
PARP inhibitor veliparib and HDAC inhibitor SAHA synergistically co-target the UHRF1/BRCA1 DNA damage repair complex in prostate cancer cells.
Yin L, Liu Y, Peng Y, Peng Y, Yu X, Gao Y, Yuan B, Zhu Q, Cao T, He L, Gong Z, Sun L, Fan X, Li X. Yin L, et al. J Exp Clin Cancer Res. 2018 Jul 16;37(1):153. doi: 10.1186/s13046-018-0810-7. J Exp Clin Cancer Res. 2018. PMID: 30012171 Free PMC article.
BACKGROUND: The poly ADP ribose polymerase (PARP) inhibitor olaparib has been approved for treating prostate cancer (PCa) with BRCA mutations, and veliparib, another PARP inhibitor, is being tested in clinical trials. ...Mechanistically, veliparib or SAHA alone redu …
BACKGROUND: The poly ADP ribose polymerase (PARP) inhibitor olaparib has been approved for treating prostate cancer (PCa) with BRCA m …
KLF5 Promotes Tumor Progression and Parp Inhibitor Resistance in Ovarian Cancer.
Wu Y, Chen S, Shao Y, Su Y, Li Q, Wu J, Zhu J, Wen H, Huang Y, Zheng Z, Chen X, Ju X, Huang S, Wu X, Hu Z. Wu Y, et al. Adv Sci (Weinh). 2023 Nov;10(31):e2304638. doi: 10.1002/advs.202304638. Epub 2023 Sep 13. Adv Sci (Weinh). 2023. PMID: 37702443 Free PMC article.
Here, super-enhancer (SE) regulatory elements that are aberrantly activated in OC are identified and it is found that SEs drive the relative specific expression of the transcription factor KLF5 in OC patients and poly(ADP-ribose) polymerase inhibitor (PARPi)-resistant pati …
Here, super-enhancer (SE) regulatory elements that are aberrantly activated in OC are identified and it is found that SEs drive the relative …
Persistence length of alpha-helical poly-L-lysine.
Wilcox KG, Dingle ME, Saha A, Hore MJA, Morozova S. Wilcox KG, et al. Soft Matter. 2022 Sep 14;18(35):6550-6560. doi: 10.1039/d2sm00921h. Soft Matter. 2022. PMID: 36039676
In this study, we investigate the persistence length, l(p), of alpha-helical poly-L-lysine, PLL, for two molecular weights. PLL experiences a random coil-helix transition as the pH is raised from 7 to 12. ...
In this study, we investigate the persistence length, l(p), of alpha-helical poly-L-lysine, PLL, for two molecular weights. PLL exper …
Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice.
Ambade A, Lowe P, Kodys K, Catalano D, Gyongyosi B, Cho Y, Iracheta-Vellve A, Adejumo A, Saha B, Calenda C, Mehta J, Lefebvre E, Vig P, Szabo G. Ambade A, et al. Hepatology. 2019 Mar;69(3):1105-1121. doi: 10.1002/hep.30249. Epub 2019 Feb 12. Hepatology. 2019. PMID: 30179264 Free PMC article.
We found that CCL2 and CCL5 sensitized hepatocytes to lipopolysaccharide-induced liver injury (TNF-alpha, ALT, and lactate dehydrogenase release). Alcohol feeding induced apoptosis (poly ADP-ribose polymerase [PARP] and caspase-3 [CASP-3] cleavage) and pyroptosis (gasdermi …
We found that CCL2 and CCL5 sensitized hepatocytes to lipopolysaccharide-induced liver injury (TNF-alpha, ALT, and lactate dehydrogenase rel …
Poly's plea: membership to the club of APCs.
Ashtekar AR, Saha B. Ashtekar AR, et al. Trends Immunol. 2003 Sep;24(9):485-90. doi: 10.1016/s1471-4906(03)00235-7. Trends Immunol. 2003. PMID: 12967672 Review. No abstract available.
Combinatorial Study of a Novel Poly (ADP-ribose) Polymerase Inhibitor and an HDAC Inhibitor, SAHA, in Leukemic Cell Lines.
Hegde M, Mantelingu K, Pandey M, Pavankumar CS, Rangappa KS, Raghavan SC. Hegde M, et al. Target Oncol. 2016 Oct;11(5):655-665. doi: 10.1007/s11523-016-0441-x. Target Oncol. 2016. PMID: 27188390
OBJECTIVE: The purpose of this study was to investigate the combinatorial effects of a novel PARP inhibitor, P10, and HDAC inhibitor, SAHA, in leukemic cells. METHODS: Combinatorial effects of P10 and SAHA were tested using propidium iodide staining in different leu …
OBJECTIVE: The purpose of this study was to investigate the combinatorial effects of a novel PARP inhibitor, P10, and HDAC inhibitor, SAH …
Pendant HDAC inhibitor SAHA derivatised polymer as a novel prodrug micellar carrier for anticancer drugs.
Xu J, Sun J, Wang P, Ma X, Li S. Xu J, et al. J Drug Target. 2018 Jun-Jul;26(5-6):448-457. doi: 10.1080/1061186X.2017.1419355. Epub 2017 Dec 27. J Drug Target. 2018. PMID: 29251528 Free PMC article.
Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor (HDACi) approved by FDA for the treatment of cutaneous T cell lymphoma, is a promising anticancer drug for various cancers with a unique mode of action. However, it demonstrates limited clinical benefi …
Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor (HDACi) approved by FDA for the treatment of cutaneous T cell …
Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances anti-tumor effects of the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib in triple-negative breast cancer cells.
Min A, Im SA, Kim DK, Song SH, Kim HJ, Lee KH, Kim TY, Han SW, Oh DY, Kim TY, O'Connor MJ, Bang YJ. Min A, et al. Breast Cancer Res. 2015 Mar 7;17:33. doi: 10.1186/s13058-015-0534-y. Breast Cancer Res. 2015. PMID: 25888415 Free PMC article.
We evaluated how exposure to SAHA affects the expression of HRR-associated genes. The accumulation of DNA double strand breaks (DSBs) induced by combination treatment was assessed. ...CONCLUSION: Our findings suggest that expression of functional PTEN may serve as a biomar …
We evaluated how exposure to SAHA affects the expression of HRR-associated genes. The accumulation of DNA double strand breaks (DSBs) …
Ultrasonic Atomizer-Driven Development of Biocompatible and Biodegradable Poly(d,l-lactide-co-glycolide) Nanocarrier-Encapsulated Suberoylanilide Hydroxamic Acid to Combat Brain Cancer.
Kaur J, Jakhmola S, Singh RR, Joshi B, Jha HC, Joshi A. Kaur J, et al. ACS Appl Bio Mater. 2021 Jul 19;4(7):5627-5637. doi: 10.1021/acsabm.1c00430. Epub 2021 Jun 20. ACS Appl Bio Mater. 2021. PMID: 35006730
Herein, we have fabricated SAHA incorporated into biocompatible and biodegradable poly(d,l-lactide-co-glycolide) PLGA nanoparticles (NPs) using a facile method of ultrasonic atomization and evaluated their anticancer property. ...SAHA-PLGA NP-treated cells al …
Herein, we have fabricated SAHA incorporated into biocompatible and biodegradable poly(d,l-lactide-co-glycolide) PLGA nanopart …
311 results