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The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition.
Eur J Clin Pharmacol. 2008 Jan;64(1):31-41. doi: 10.1007/s00228-007-0396-z. Epub 2007 Nov 14.
Eur J Clin Pharmacol. 2008.
PMID: 18000659
Clinical Trial.
Metabolism and excretion of erlotinib, a small molecule inhibitor of epidermal growth factor receptor tyrosine kinase, in healthy male volunteers.
Ling J, Johnson KA, Miao Z, Rakhit A, Pantze MP, Hamilton M, Lum BL, Prakash C.
Ling J, et al. Among authors: pantze mp.
Drug Metab Dispos. 2006 Mar;34(3):420-6. doi: 10.1124/dmd.105.007765. Epub 2005 Dec 28.
Drug Metab Dispos. 2006.
PMID: 16381666
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