R-Loop-Mediated ssDNA Breaks Accumulate Following Short-Term Exposure to the HDAC Inhibitor Romidepsin.
Safari M, Litman T, Robey RW, Aguilera A, Chakraborty AR, Reinhold WC, Basseville A, Petrukhin L, Scotto L, O'Connor OA, Pommier Y, Fojo AT, Bates SE.
Safari M, et al.
Mol Cancer Res. 2021 Aug;19(8):1361-1374. doi: 10.1158/1541-7786.MCR-20-0833. Epub 2021 May 28.
Mol Cancer Res. 2021.
PMID: 34050002
Free PMC article.
We show that inhibition of BER proteins such as PARP will increase dsDNA breaks in this context. These studies establish accumulation of R-loops as a consequence of romidepsin-mediated histone hyperacetylation. ...IMPLICATIONS: Key HDAC inhibitor mechanisms of action remai …
We show that inhibition of BER proteins such as PARP will increase dsDNA breaks in this context. These studies establish accumulation of …