Enhanced production of taxadiene in Saccharomyces cerevisiae.
Nowrouzi B, Li RA, Walls LE, d'Espaux L, Malcı K, Liang L, Jonguitud-Borrego N, Lerma-Escalera AI, Morones-Ramirez JR, Keasling JD, Rios-Solis L.
Nowrouzi B, et al.
Microb Cell Fact. 2020 Nov 2;19(1):200. doi: 10.1186/s12934-020-01458-2.
Microb Cell Fact. 2020.
PMID: 33138820
Free PMC article.
In this study, the key challenge of poor taxadiene synthase (TASY) solubility in S. cerevisiae was revealed, and the strains were strategically engineered to relieve this bottleneck. ...CONCLUSIONS: The results of this study highlight the benefit of employing a combination …
In this study, the key challenge of poor taxadiene synthase (TASY) solubility in S. cerevisiae was revealed, and the strains were str …