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Identification of NLRP3PYD Homo-Oligomerization Inhibitors with Anti-Inflammatory Activity.
Moasses Ghafary S, Soriano-Teruel PM, Lotfollahzadeh S, Sancho M, Serrano-Candelas E, Karami F, Barigye SJ, Fernández-Pérez I, Gozalbes R, Nikkhah M, Orzáez M, Hosseinkhani S. Moasses Ghafary S, et al. Int J Mol Sci. 2022 Jan 31;23(3):1651. doi: 10.3390/ijms23031651. Int J Mol Sci. 2022. PMID: 35163573 Free PMC article.
The dysregulation of the best-characterized complex, the NLRP3 inflammasome, has been linked to the pathogenesis of diseases such as multiple sclerosis, type 2 diabetes mellitus, Alzheimer's disease, and cancer. While there exist molecular inhibitors specific for the vario …
The dysregulation of the best-characterized complex, the NLRP3 inflammasome, has been linked to the pathogenesis of diseases such as multipl …