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Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce.
Li Q, Hagberg CE, Silva Cascales H, Lang S, Hyvönen MT, Salehzadeh F, Chen P, Alexandersson I, Terezaki E, Harms MJ, Kutschke M, Arifen N, Krämer N, Aouadi M, Knibbe C, Boucher J, Thorell A, Spalding KL. Li Q, et al. Among authors: silva cascales h. Nat Med. 2021 Nov;27(11):1941-1953. doi: 10.1038/s41591-021-01501-8. Epub 2021 Oct 4. Nat Med. 2021. PMID: 34608330
How the cell cycle enforces senescence.
Silva Cascales H, Müllers E, Lindqvist A. Silva Cascales H, et al. Aging (Albany NY). 2017 Oct 30;9(10):2022-2023. doi: 10.18632/aging.101316. Aging (Albany NY). 2017. PMID: 29084933 Free PMC article. No abstract available.
Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1.
Silva Cascales H, Burdova K, Middleton A, Kuzin V, Müllers E, Stoy H, Baranello L, Macurek L, Lindqvist A. Silva Cascales H, et al. Life Sci Alliance. 2021 Jan 5;4(3):e202000980. doi: 10.26508/lsa.202000980. Print 2021 Mar. Life Sci Alliance. 2021. PMID: 33402344 Free PMC article.
Residual Cdk1/2 activity after DNA damage promotes senescence.
Müllers E, Silva Cascales H, Burdova K, Macurek L, Lindqvist A. Müllers E, et al. Among authors: silva cascales h. Aging Cell. 2017 Jun;16(3):575-584. doi: 10.1111/acel.12588. Epub 2017 Mar 26. Aging Cell. 2017. PMID: 28345297 Free PMC article.