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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 3
1979 1
1983 1
1985 1
1987 1
1989 1
1990 1
1991 1
1992 1
1993 1
1997 2
1998 1
1999 5
2000 2
2001 1
2002 2
2007 2
2008 3
2011 3
2012 1
2013 1
2014 1
2015 3
2016 6
2017 2
2018 1
2019 2
2020 1
2022 3
2023 2
2024 0

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50 results

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Page 1
Fragment-based and structure-guided discovery of perforin inhibitors.
Jose J, Law RHP, Leung EWW, Wai DCC, Akhlaghi H, Chandrashekaran IR, Caradoc-Davies TT, Voskoboinik I, Feutrill J, Middlemiss D, Jeevarajah D, Bashtannyk-Puhalovich T, Giddens AC, Lee TW, Jamieson SMF, Trapani JA, Whisstock JC, Spicer JA, Norton RS. Jose J, et al. Among authors: spicer ja. Eur J Med Chem. 2023 Dec 5;261:115786. doi: 10.1016/j.ejmech.2023.115786. Epub 2023 Sep 1. Eur J Med Chem. 2023. PMID: 37716187 Free article.
Effects of a Small-Molecule Perforin Inhibitor in a Mouse Model of CD8 T Cell-Mediated Neuroinflammation.
Gonzalez-Fierro C, Fonte C, Dufourd E, Cazaentre V, Aydin S, Engelhardt B, Caspi RR, Xu B, Martin-Blondel G, Spicer JA, Trapani JA, Bauer J, Liblau RS, Bost C. Gonzalez-Fierro C, et al. Among authors: spicer ja. Neurol Neuroimmunol Neuroinflamm. 2023 Apr 20;10(4):e200117. doi: 10.1212/NXI.0000000000200117. Print 2023 Jul. Neurol Neuroimmunol Neuroinflamm. 2023. PMID: 37080596 Free PMC article.
Substituted arylsulphonamides as inhibitors of perforin-mediated lysis.
Spicer JA, Miller CK, O'Connor PD, Jose J, Huttunen KM, Jaiswal JK, Denny WA, Akhlaghi H, Browne KA, Trapani JA. Spicer JA, et al. Eur J Med Chem. 2017 Sep 8;137:139-155. doi: 10.1016/j.ejmech.2017.05.048. Epub 2017 May 26. Eur J Med Chem. 2017. PMID: 28582670 Free PMC article.
Ethyl 4-hydroxy-methyl-2-methyl-pyridine-5-carboxyl-ate.
Boyd PD, Lena G, Spicer JA. Boyd PD, et al. Among authors: spicer ja. Acta Crystallogr Sect E Struct Rep Online. 2008 Apr 23;64(Pt 5):o883. doi: 10.1107/S160053680801026X. Acta Crystallogr Sect E Struct Rep Online. 2008. PMID: 21202367 Free PMC article.
Benzenesulphonamide inhibitors of the cytolytic protein perforin.
Spicer JA, Miller CK, O'Connor PD, Jose J, Huttunen KM, Jaiswal JK, Denny WA, Akhlaghi H, Browne KA, Trapani JA. Spicer JA, et al. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1050-1054. doi: 10.1016/j.bmcl.2016.12.057. Epub 2016 Dec 23. Bioorg Med Chem Lett. 2017. PMID: 28110869 Free PMC article.
Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis.
Welz M, Eickhoff S, Abdullah Z, Trebicka J, Gartlan KH, Spicer JA, Demetris AJ, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani JA, Knolle P, Wohlleber D, Kastenmüller W. Welz M, et al. Among authors: spicer ja. Nat Commun. 2018 Nov 15;9(1):4805. doi: 10.1038/s41467-018-07213-x. Nat Commun. 2018. PMID: 30442932 Free PMC article.
50 results