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96 results

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Page 1
Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging.
Ogura M, Kaminishi T, Shima T, Torigata M, Bekku N, Tabata K, Minami S, Nishino K, Nezu A, Hamasaki M, Kosako H, Yoshimori T, Nakamura S. Ogura M, et al. EMBO Rep. 2023 Dec 6;24(12):e57300. doi: 10.15252/embr.202357300. Epub 2023 Nov 21. EMBO Rep. 2023. PMID: 37987447 Free PMC article.
Here, we demonstrate that damaged lysosomal membranes are repaired by microautophagy (a process termed "microlysophagy") and identify key regulators of the first and last steps. We reveal the AGC kinase STK38 as a novel microlysophagy regulator. Through phosphorylation of …
Here, we demonstrate that damaged lysosomal membranes are repaired by microautophagy (a process termed "microlysophagy") and identify key re …
The STK38-XPO1 axis, a new actor in physiology and cancer.
Martin AP, Aushev VN, Zalcman G, Camonis JH. Martin AP, et al. Cell Mol Life Sci. 2021 Mar;78(5):1943-1955. doi: 10.1007/s00018-020-03690-w. Epub 2020 Nov 3. Cell Mol Life Sci. 2021. PMID: 33145612 Free PMC article. Review.
Here, we will briefly introduce the Hippo tumor suppressor pathway before focusing on one of its members and the unexpected twists that followed our quest of its functions in its multifarious actions beside the Hippo pathway: the STK38 kinase. In this review, we will preci …
Here, we will briefly introduce the Hippo tumor suppressor pathway before focusing on one of its members and the unexpected twists that foll …
NLRP12 downregulates the Wnt/beta-catenin pathway via interaction with STK38 to suppress colorectal cancer.
Khan S, Kwak YT, Peng L, Hu S, Cantarel BL, Lewis CM, Gao Y, Mani RS, Kanneganti TD, Zaki H. Khan S, et al. J Clin Invest. 2023 Oct 2;133(19):e166295. doi: 10.1172/JCI166295. J Clin Invest. 2023. PMID: 37581937 Free PMC article.
Consistent with this, Nlrp12-deficient intestinal organoids and CRC cells showed increased proliferation, accompanied by higher activation of beta-catenin in vitro. With proteomic studies, we identified STK38 as an interacting partner of NLRP12 involved in the inhibition o …
Consistent with this, Nlrp12-deficient intestinal organoids and CRC cells showed increased proliferation, accompanied by higher activation o …
STK38 is a PPARgamma-interacting protein promoting adipogenesis.
Qian K, Yu D, Wang W, Jiang M, Yang R, Brown R, Gong DW. Qian K, et al. Adipocyte. 2021 Dec;10(1):524-531. doi: 10.1080/21623945.2021.1980257. Adipocyte. 2021. PMID: 34670478 Free PMC article.
In cell-based assays, STK38 increased PPARgamma protein stability, extending PPARgamma's half-life from ~1.08 to 1.95 h. ...Thus, we discovered that STK38 is a novel PPARgamma-cofactor promoting adipogenesis, likely through stabilization of PPARgamma....
In cell-based assays, STK38 increased PPARgamma protein stability, extending PPARgamma's half-life from ~1.08 to 1.95 h. ...Thus, we …
The hippo kinase STK38 ensures functionality of XPO1.
Martin AP, Camonis JH. Martin AP, et al. Cell Cycle. 2020 Nov;19(22):2982-2995. doi: 10.1080/15384101.2020.1826619. Epub 2020 Oct 5. Cell Cycle. 2020. PMID: 33017560 Free PMC article. Review.
XPO1 (Exportin 1) is the major nuclear export receptor and is required for the export of proteins and RNAs out of the nucleus. STK38 (also known as NDR1) is a Hippo pathway serine/threonine kinase with multifarious functions in normal and cancer cells. ...We discuss the re …
XPO1 (Exportin 1) is the major nuclear export receptor and is required for the export of proteins and RNAs out of the nucleus. STK38
The Role of Mammalian STK38 in DNA Damage Response and Targeting for Radio-Sensitization.
Fukasawa T, Enomoto A, Yoshizaki-Ogawa A, Sato S, Miyagawa K, Yoshizaki A. Fukasawa T, et al. Cancers (Basel). 2023 Mar 30;15(7):2054. doi: 10.3390/cancers15072054. Cancers (Basel). 2023. PMID: 37046714 Free PMC article. Review.
Protein kinases, found in the nucleus and cytoplasm, play essential roles in a multitude of cellular processes, including cell division, proliferation, apoptosis, and signal transduction. STK38 is a member of the protein kinase A (PKA)/PKG/PKC family implicated in regulati …
Protein kinases, found in the nucleus and cytoplasm, play essential roles in a multitude of cellular processes, including cell division, pro …
STK38 at the crossroad between autophagy and apoptosis.
Joffre C, Codogno P, Fanto M, Hergovich A, Camonis J. Joffre C, et al. Autophagy. 2016;12(3):594-5. doi: 10.1080/15548627.2015.1135283. Epub 2016 Feb 18. Autophagy. 2016. PMID: 26890257 Free PMC article.
We describe the STK38 protein kinase as a conserved regulator of autophagy. We discovered STK38 as a novel binding partner of Beclin1, a key regulator of autophagy. ...Furthermore, we also provide evidence demonstrating that STK38 with the small GTPase RalB, …
We describe the STK38 protein kinase as a conserved regulator of autophagy. We discovered STK38 as a novel binding partner of …
STK38 promotes ATM activation by acting as a reader of histone H4 ufmylation.
Qin B, Yu J, Nowsheen S, Zhao F, Wang L, Lou Z. Qin B, et al. Sci Adv. 2020 Jun 3;6(23):eaax8214. doi: 10.1126/sciadv.aax8214. eCollection 2020 Jun. Sci Adv. 2020. PMID: 32537488 Free PMC article.
STK38 contains a potential UFM1 binding motif which recognizes ufmylated H4 and recruits the SUV39H1 to the double-strand breaks, resulting in H3K9 trimethylation and Tip60 activation to promote ATM activation. Together, STK38 is a previously unknown player in DNA d
STK38 contains a potential UFM1 binding motif which recognizes ufmylated H4 and recruits the SUV39H1 to the double-strand breaks, res
STK38 kinase acts as XPO1 gatekeeper regulating the nuclear export of autophagy proteins and other cargoes.
Martin AP, Jacquemyn M, Lipecka J, Chhuon C, Aushev VN, Meunier B, Singh MK, Carpi N, Piel M, Codogno P, Hergovich A, Parrini MC, Zalcman G, Guerrera IC, Daelemans D, Camonis JH. Martin AP, et al. EMBO Rep. 2019 Nov 5;20(11):e48150. doi: 10.15252/embr.201948150. Epub 2019 Sep 23. EMBO Rep. 2019. PMID: 31544310 Free PMC article.
We show that STK38 shuttles between the nucleus and the cytoplasm and that its nuclear exit depends on both XPO1 (aka exportin-1, CRM1) and STK38 kinase activity. ...Collectively, our results reveal STK38 as an activator of XPO1, behaving as a gatekeeper of n …
We show that STK38 shuttles between the nucleus and the cytoplasm and that its nuclear exit depends on both XPO1 (aka exportin-1, CRM …
Stk38 Modulates Rbm24 Protein Stability to Regulate Sarcomere Assembly in Cardiomyocytes.
Liu J, Kong X, Lee YM, Zhang MK, Guo LY, Lin Y, Lim TK, Lin Q, Xu XQ. Liu J, et al. Sci Rep. 2017 Mar 21;7:44870. doi: 10.1038/srep44870. Sci Rep. 2017. PMID: 28322254 Free PMC article.
Yet, its underlying mechanism remains unclear. Here, we link serine/threonine kinase 38 (Stk38) signaling to the regulation of Rbm24 by showing that Rbm24 phosphorylation and its function could be modulated by Stk38. ...Deficiency of Stk38 caused reduction of …
Yet, its underlying mechanism remains unclear. Here, we link serine/threonine kinase 38 (Stk38) signaling to the regulation of Rbm24 …
96 results