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Did you mean t mirzoev (71 results)?
Microglia-T cell conversations in brain cancer progression.
Mirzaei R, Yong VW. Mirzaei R, et al. Trends Mol Med. 2022 Nov;28(11):951-963. doi: 10.1016/j.molmed.2022.08.006. Epub 2022 Sep 5. Trends Mol Med. 2022. PMID: 36075812 Review.
We review the mechanisms of T cell-microglia interactions and discuss how their collaboration fosters heterogeneity and immunosuppression in brain cancers. Because of the importance of microglia and T cells in the brain tumor microenvironment, it is crucial to under …
We review the mechanisms of T cell-microglia interactions and discuss how their collaboration fosters heterogeneity and immunosuppres …
Outsmarting trogocytosis to boost CAR NK/T cell therapy.
Ramezani F, Panahi Meymandi AR, Akbari B, Tamtaji OR, Mirzaei H, Brown CE, Mirzaei HR. Ramezani F, et al. Mol Cancer. 2023 Nov 16;22(1):183. doi: 10.1186/s12943-023-01894-9. Mol Cancer. 2023. PMID: 37974170 Free PMC article. Review.
Chimeric antigen receptor (CAR) NK and T cell therapy are promising immunotherapeutic approaches for the treatment of cancer. ...In this review, we explore the role of trogocytosis in CAR NK/T cell therapy and highlight potential strategies for its modulation to imp …
Chimeric antigen receptor (CAR) NK and T cell therapy are promising immunotherapeutic approaches for the treatment of cancer. ...In t …
Epigenetic strategies to boost CAR T cell therapy.
Akbari B, Ghahri-Saremi N, Soltantoyeh T, Hadjati J, Ghassemi S, Mirzaei HR. Akbari B, et al. Mol Ther. 2021 Sep 1;29(9):2640-2659. doi: 10.1016/j.ymthe.2021.08.003. Epub 2021 Aug 6. Mol Ther. 2021. PMID: 34365035 Free PMC article. Review.
Chimeric antigen receptor (CAR) T cell therapy has led to a paradigm shift in cancer immunotherapy, but still several obstacles limit CAR T cell efficacy in cancers. ...We also offer our perspective on how selected epigenetic modifications can boost CAR T cel …
Chimeric antigen receptor (CAR) T cell therapy has led to a paradigm shift in cancer immunotherapy, but still several obstacles limit …
Mitochondria as Playmakers of CAR T-cell Fate and Longevity.
Rostamian H, Khakpoor-Koosheh M, Fallah-Mehrjardi K, Mirzaei HR, Brown CE. Rostamian H, et al. Cancer Immunol Res. 2021 Aug;9(8):856-861. doi: 10.1158/2326-6066.CIR-21-0110. Cancer Immunol Res. 2021. PMID: 34344697 Review.
Development of strategies based on the generation and maintenance of long-lasting memory T cells may expand the therapeutic effects of CAR T cells. Mitochondrial metabolic pathways play crucial roles in regulating the fate, function, and longevity of T cells. …
Development of strategies based on the generation and maintenance of long-lasting memory T cells may expand the therapeutic effects o …
Crosstalk between autophagy and metabolic regulation of (CAR) T cells: therapeutic implications.
Panahi Meymandi AR, Akbari B, Soltantoyeh T, Hadjati J, Klionsky DJ, Badie B, Mirzaei HR. Panahi Meymandi AR, et al. Front Immunol. 2023 Aug 22;14:1212695. doi: 10.3389/fimmu.2023.1212695. eCollection 2023. Front Immunol. 2023. PMID: 37675121 Free PMC article. Review.
This has prompted investigating new approaches for producing CAR T cells with superior therapeutic potential. Emerging insights into the barriers to CAR T cell clinical success indicate that autophagy shapes the immune response via reprogramming cellular metabolism …
This has prompted investigating new approaches for producing CAR T cells with superior therapeutic potential. Emerging insights into …
Metabolic and epigenetic orchestration of (CAR) T cell fate and function.
Akbari B, Hosseini Z, Shahabinejad P, Ghassemi S, Mirzaei HR, O'Connor RS. Akbari B, et al. Cancer Lett. 2022 Dec 1;550:215948. doi: 10.1016/j.canlet.2022.215948. Epub 2022 Oct 7. Cancer Lett. 2022. PMID: 36209973 Review.
Longevity, functionality, and metabolic fitness are key determinants of chimeric antigen receptor (CAR) T cell efficacy. Activated T cells follow an ordered differentiation program which is facilitated by metabolic adaptations. In response to antigen, T cells …
Longevity, functionality, and metabolic fitness are key determinants of chimeric antigen receptor (CAR) T cell efficacy. Activated …
T Cell Exhaustion in Glioblastoma: Intricacies of Immune Checkpoints.
Mirzaei R, Sarkar S, Yong VW. Mirzaei R, et al. Trends Immunol. 2017 Feb;38(2):104-115. doi: 10.1016/j.it.2016.11.005. Epub 2016 Dec 7. Trends Immunol. 2017. PMID: 27964820 Review.
While the blockade of immune checkpoints leads to reversal of T cell exhaustion in many cancers, the efficacy of this therapy in glioblastoma requires further consideration of the brain microenvironment beyond T cell activity. Neural cells are crucially dependent on …
While the blockade of immune checkpoints leads to reversal of T cell exhaustion in many cancers, the efficacy of this therapy in glio …
Targeting regulatory T cells by curcumin: A potential for cancer immunotherapy.
Shafabakhsh R, Pourhanifeh MH, Mirzaei HR, Sahebkar A, Asemi Z, Mirzaei H. Shafabakhsh R, et al. Pharmacol Res. 2019 Sep;147:104353. doi: 10.1016/j.phrs.2019.104353. Epub 2019 Jul 12. Pharmacol Res. 2019. PMID: 31306775 Review.
In this regard, some studies have indicated that this phytochemical could target regulatory T cells and convert them into T helper 1 cells, which possess anti-tumor effects. ...Herein, we describe the anti-cancer roles of curcumin via targeting regulatory T c …
In this regard, some studies have indicated that this phytochemical could target regulatory T cells and convert them into T he …
PGE2-EP2/EP4 signaling elicits mesoCAR T cell immunosuppression in pancreatic cancer.
Akbari B, Soltantoyeh T, Shahosseini Z, Jadidi-Niaragh F, Hadjati J, Brown CE, Mirzaei HR. Akbari B, et al. Front Immunol. 2023 Jun 30;14:1209572. doi: 10.3389/fimmu.2023.1209572. eCollection 2023. Front Immunol. 2023. PMID: 37457723 Free PMC article.
Through our in vitro study, we manufactured fully human functional mesoCAR T cells specific for pancreatic cancer and investigated the influence of PGE2-EP2/EP4 signaling on proliferation, cytotoxicity, and cytokine production of mesoCAR T cells against pancreatic c …
Through our in vitro study, we manufactured fully human functional mesoCAR T cells specific for pancreatic cancer and investigated th …
897 results