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Page 1
Glucagon-like peptide 1 receptor is a T cell-negative costimulatory molecule.
Ben Nasr M, Usuelli V, Dellepiane S, Seelam AJ, Fiorentino TV, D'Addio F, Fiorina E, Xu C, Xie Y, Balasubramanian HB, Castillo-Leon E, Loreggian L, Maestroni A, Assi E, Loretelli C, Abdelsalam A, El Essawy B, Uccella S, Pastore I, Lunati ME, Sabiu G, Petrazzuolo A, Ducci G, Sacco E, Centofanti L, Venturini M, Mazzucchelli S, Mattinzoli D, Ikehata M, Castellano G, Visner G, Kaifeng L, Lee KM, Wang Z, Corradi D, La Rosa S, Danese S, Yang J, Markmann JF, Zuccotti GV, Abdi R, Folli F, Fiorina P. Ben Nasr M, et al. Cell Metab. 2024 Jun 4;36(6):1302-1319.e12. doi: 10.1016/j.cmet.2024.05.001. Cell Metab. 2024. PMID: 38838642
We herein investigated the role of GLP-1R on T lymphocytes during immune response. Our data showed that a subset of T lymphocytes expresses GLP-1R, which is upregulated during alloimmune response, similarly to PD-1. ...GLP-1R acts as a T cell-negative costimu …
We herein investigated the role of GLP-1R on T lymphocytes during immune response. Our data showed that a subset of T lymphocy …
Monoclonal Immunoglobulin Crystalline Membranous Nephropathy.
Mignano SE, Pascal V, Odioemene NE, Forehand W, Javaugue V, Said SM, Sethi S, Sirac C, Nasr SH. Mignano SE, et al. Am J Kidney Dis. 2024 Jul;84(1):120-125. doi: 10.1053/j.ajkd.2023.11.011. Epub 2024 Jan 23. Am J Kidney Dis. 2024. PMID: 38266972
OMIP-096: A 24-color flow cytometry panel to identify and characterize CD4+ and CD8+ tissue-resident T cells in human skin, intestinal, and type II mucosal tissue.
O'Neil TR, Harman AN, Cunningham AL, Nasr N, Bertram KM. O'Neil TR, et al. Cytometry A. 2023 Nov;103(11):851-856. doi: 10.1002/cyto.a.24782. Epub 2023 Sep 29. Cytometry A. 2023. PMID: 37772977 Free PMC article.
There is a great need to understand human immune cells within tissue, where disease manifests and infection occurs. Tissue-resident memory T cells (TRMs) were discovered over a decade ago, there is a great need to understand their role in human disease. ...Here we carefull …
There is a great need to understand human immune cells within tissue, where disease manifests and infection occurs. Tissue-resident memory …
Subclinical hypothyroidism: When to treat.
Azim S, Nasr C. Azim S, et al. Cleve Clin J Med. 2019 Feb;86(2):101-110. doi: 10.3949/ccjm.86a.17053. Cleve Clin J Med. 2019. PMID: 30742580 Free article. Review.
Subclinical hypothyroidism is defined by an elevated serum thyroid-stimulating hormone (TSH) level along with a normal free thyroxine (T(4)) level. Whether it should be treated remains controversial. Currently, the best practical approach is to base treatment decisions on …
Subclinical hypothyroidism is defined by an elevated serum thyroid-stimulating hormone (TSH) level along with a normal free thyroxine (T …
Providing rigor in bee colony strength auditing methods.
Cook D, Hauxwell C. Cook D, et al. J Econ Entomol. 2024 Apr 12;117(2):410-416. doi: 10.1093/jee/toae032. J Econ Entomol. 2024. PMID: 38439717 Free PMC article.
The primary method used to audit honey bee (Apis mellifera Linnaeus, 1758 [Hymenoptera: Apidae]) colony strength for almond pollination services, Nasr et al.'s (1990) frame-top cluster count method, is a subjective visual audit that relies on an auditor's spot assessment a …
The primary method used to audit honey bee (Apis mellifera Linnaeus, 1758 [Hymenoptera: Apidae]) colony strength for almond pollination serv …
Regulatory B Cells in Autoimmune Diabetes.
Ben Nasr M, Usuelli V, Seelam AJ, D'Addio F, Abdi R, Markmann JF, Fiorina P. Ben Nasr M, et al. J Immunol. 2021 Mar 15;206(6):1117-1125. doi: 10.4049/jimmunol.2001127. J Immunol. 2021. PMID: 33685919 Review.
Overview of Targeted Therapies for Adult T-Cell Leukemia/Lymphoma.
Nasr R, Marçais A, Hermine O, Bazarbachi A. Nasr R, et al. Methods Mol Biol. 2017;1582:197-216. doi: 10.1007/978-1-4939-6872-5_15. Methods Mol Biol. 2017. PMID: 28357672 Review.
Adult T-Cell Leukemia/lymphoma (ATL) is the first human malignancy associated with a chronic infection by a retrovirus, the human T-cell lymphotropic virus type I (HTLV-I). ...
Adult T-Cell Leukemia/lymphoma (ATL) is the first human malignancy associated with a chronic infection by a retrovirus, the human …
Observation of Sub-Microsecond Protein Methyl-Side Chain Dynamics by Nanoparticle-Assisted NMR Spin Relaxation.
Xiang X, Hansen AL, Yu L, Jameson G, Bruschweiler-Li L, Yuan C, Brüschweiler R. Xiang X, et al. J Am Chem Soc. 2021 Sep 1;143(34):13593-13604. doi: 10.1021/jacs.1c04687. Epub 2021 Aug 24. J Am Chem Soc. 2021. PMID: 34428032 Free article.
Nanoparticle-assisted NMR spin relaxation (NASR) of methyl-side chains is introduced here as a window into these ns-mus dynamics. NASR utilizes the transient and nonspecific interactions between folded proteins and slowly tumbling spherical nanoparticles (NPs), wher …
Nanoparticle-assisted NMR spin relaxation (NASR) of methyl-side chains is introduced here as a window into these ns-mus dynamics. …
An autoinhibitory mechanism controls RNA-binding activity of the nitrate-sensing protein NasR.
Goodson JR, Zhang C, Trettel D, Ailinger HE, Lee PE, Spirito CM, Winkler WC. Goodson JR, et al. Mol Microbiol. 2020 Aug;114(2):348-360. doi: 10.1111/mmi.14517. Epub 2020 May 13. Mol Microbiol. 2020. PMID: 32314426 Free PMC article.
We subjected the corresponding positions of Klebsiella oxytoca NasR to site-directed alanine substitutions and measured RNA-binding activity. This revealed a functionally important patch of residues that forms amino acid pairing interactions with residues from NasR' …
We subjected the corresponding positions of Klebsiella oxytoca NasR to site-directed alanine substitutions and measured RNA-binding a …
Evolving Strategies to Eliminate the CD4 T Cells HIV Viral Reservoir via CAR T Cell Immunotherapy.
York J, Gowrishankar K, Micklethwaite K, Palmer S, Cunningham AL, Nasr N. York J, et al. Front Immunol. 2022 Apr 29;13:873701. doi: 10.3389/fimmu.2022.873701. eCollection 2022. Front Immunol. 2022. PMID: 35572509 Free PMC article. Review.
While several strategies involving HIV silencing or its reactivation in latently infected cells for elimination by immune responses have been explored, exciting cell based immune therapies involving genetically engineered T cells expressing synthetic chimeric receptors (CA …
While several strategies involving HIV silencing or its reactivation in latently infected cells for elimination by immune responses have bee …
1,530 results