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Methionine restriction fundamentally supports health by tightening epithelial barriers.

Mullin JM, Skrovanek SM, Ramalingam A, DiGuilio KM, Valenzano MC. Mullin JM, et al. Among authors: valenzano mc. Ann N Y Acad Sci. 2016 Jan;1363:59-67. doi: 10.1111/nyas.12955. Epub 2015 Dec 8. Ann N Y Acad Sci. 2016. PMID: 26646941 Free PMC article. Review.

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Zinc Gluconate Induces Potentially Cancer Chemopreventive Activity in Barrett's Esophagus: A Phase 1 Pilot Study.

Valenzano MC, Rybakovsky E, Chen V, Leroy K, Lander J, Richardson E, Yalamanchili S, McShane S, Mathew A, Mayilvaganan B, Connor L, Urbas R, Huntington W, Corcoran A, Trembeth S, McDonnell E, Wong P, Newman G, Mercogliano G, Zitin M, Etemad B, Thornton J, Daum G, Raines J, Kossenkov A, Fong LY, Mullin JM. Valenzano MC, et al. Dig Dis Sci. 2021 Apr;66(4):1195-1211. doi: 10.1007/s10620-020-06319-x. Epub 2020 May 15. Dig Dis Sci. 2021. PMID: 32415564 Free PMC article. Clinical Trial.

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Improvement of Human-Oral-Epithelial-Barrier Function and of Tight Junctions by Micronutrients.

Rybakovsky E, Valenzano MC, Deis R, DiGuilio KM, Thomas S, Mullin JM. Rybakovsky E, et al. Among authors: valenzano mc. J Agric Food Chem. 2017 Dec 20;65(50):10950-10958. doi: 10.1021/acs.jafc.7b04203. Epub 2017 Dec 7. J Agric Food Chem. 2017. PMID: 29172516

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Improving Transient Transfection Efficiency in a Differentiated, Polar Epithelial Cell Layer.

Rybakovsky E, Valenzano MC, DiGuilio KM, Buleza NB, Moskalenko DV, Harty RN, Mullin JM. Rybakovsky E, et al. Among authors: valenzano mc. J Biomol Tech. 2019 Jul;30(2):19-24. doi: 10.7171/jbt.19-3002-001. J Biomol Tech. 2019. PMID: 31037041 Free PMC article.

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Zinc reduces epithelial barrier compromise induced by human seminal plasma.

Mullin JM, Diguilio KM, Valenzano MC, Deis R, Thomas S, Zurbach EP, Abdulhaqq S, Montaner LJ. Mullin JM, et al. Among authors: valenzano mc. PLoS One. 2017 Mar 9;12(3):e0170306. doi: 10.1371/journal.pone.0170306. eCollection 2017. PLoS One. 2017. PMID: 28278250 Free PMC article.

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Omeprazole induces gastric permeability to digoxin.

Gabello M, Valenzano MC, Barr M, Zurbach P, Mullin JM. Gabello M, et al. Among authors: valenzano mc. Dig Dis Sci. 2010 May;55(5):1255-63. doi: 10.1007/s10620-009-0851-z. Epub 2009 Jun 10. Dig Dis Sci. 2010. PMID: 19513837

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Cobalt chloride compromises transepithelial barrier properties of CaCo-2 BBe human gastrointestinal epithelial cell layers.

DiGuilio KM, Valenzano MC, Rybakovsky E, Mullin JM. DiGuilio KM, et al. Among authors: valenzano mc. BMC Gastroenterol. 2018 Jan 5;18(1):2. doi: 10.1186/s12876-017-0731-5. BMC Gastroenterol. 2018. PMID: 29304733 Free PMC article.

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Transepithelial leak in Barrett's esophagus.

Mullin JM, Valenzano MC, Trembeth S, Allegretti PD, Verrecchio JJ, Schmidt JD, Jain V, Meddings JB, Mercogliano G, Thornton JJ. Mullin JM, et al. Among authors: valenzano mc. Dig Dis Sci. 2006 Dec;51(12):2326-36. doi: 10.1007/s10620-006-9478-5. Epub 2006 Nov 14. Dig Dis Sci. 2006. PMID: 17103306

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Zinc enhancement of LLC-PK(1) renal epithelial barrier function.

Wang X, Valenzano MC, Mercado JM, Zurbach EP, Flounders CJ, Mullin JM. Wang X, et al. Among authors: valenzano mc. Clin Nutr. 2014 Apr;33(2):280-6. doi: 10.1016/j.clnu.2013.05.001. Epub 2013 May 7. Clin Nutr. 2014. PMID: 23755840

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Sieving characteristics of cytokine- and peroxide-induced epithelial barrier leak: Inhibition by berberine.

DiGuilio KM, Mercogliano CM, Born J, Ferraro B, To J, Mixson B, Smith A, Valenzano MC, Mullin JM. DiGuilio KM, et al. Among authors: valenzano mc. World J Gastrointest Pathophysiol. 2016 May 15;7(2):223-34. doi: 10.4291/wjgp.v7.i2.223. World J Gastrointest Pathophysiol. 2016. PMID: 27190695 Free PMC article.

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