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Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome.
Bai R, Yuan M, Zhang P, Luo T, Shi Y, Wan R. Bai R, et al. Science. 2024 Mar 15;383(6688):1245-1252. doi: 10.1126/science.adn7272. Epub 2024 Mar 14. Science. 2024. PMID: 38484052
The atomic model includes U11 small nuclear ribonucleoprotein (snRNP), U12 snRNP, and U4atac/U6atac.U5 tri-snRNP. U11 snRNA is recognized by five U11-specific proteins (20K, 25K, 35K, 48K, and 59K) and the heptameric Sm ring. The 3' half of the 5'-splice site forms a duple …
The atomic model includes U11 small nuclear ribonucleoprotein (snRNP), U12 snRNP, and U4atac/U6atac.U5 tri-snRNP. U11 snRNA is recognized by …
Conjugation to 10 kDa Linear PEG Extends Serum Half-Life and Preserves the Receptor-Binding Ability of mmTRAIL with Minimal Stimulation of PEG-Specific Antibodies.
Nie Q, Jia D, Yang H, Feng Y, Fan Q, Shi Q, Wan L, Lu X. Nie Q, et al. Mol Pharm. 2017 Feb 6;14(2):502-512. doi: 10.1021/acs.molpharmaceut.6b00964. Epub 2017 Jan 12. Mol Pharm. 2017. PMID: 28029256
However, death receptor binding of mmTRAIL-20K was reduced 5- to 8-fold, resulting in a 3-fold reduction of cytotoxicity. Additionally, repeated administration of mmTRAIL-20K elicited both mPEG-specific IgG and IgM antibody responses in rats. ...
However, death receptor binding of mmTRAIL-20K was reduced 5- to 8-fold, resulting in a 3-fold reduction of cytotoxicity. Additionall …
Peritoneal macrophage uptake, pharmacokinetics and biodistribution of macrophage-targeted PEG-fMLF (N-formyl-methionyl-leucyl-phenylalanine) nanocarriers for improving HIV drug delivery.
Wan L, Pooyan S, Hu P, Leibowitz MJ, Stein S, Sinko PJ. Wan L, et al. Pharm Res. 2007 Nov;24(11):2110-9. doi: 10.1007/s11095-007-9402-5. Epub 2007 Aug 15. Pharm Res. 2007. PMID: 17701325 Free PMC article.
Attachment of fMLF residues increased the t(1/2) of PEG(5K) by threefold but decreased the t(1/2) of PEG(20K) by 40%. Attachment of fMLF increased accumulation of nanocarriers into macrophages of liver, kidneys and spleen. ...
Attachment of fMLF residues increased the t(1/2) of PEG(5K) by threefold but decreased the t(1/2) of PEG(20K) by 40%. Attachment of f …