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Page 1
Evaluation of the first 44Sc-labeled Affibody molecule for imaging of HER2-expressing tumors.
Honarvar H, Müller C, Cohrs S, Haller S, Westerlund K, Karlström AE, van der Meulen NP, Schibli R, Tolmachev V. Honarvar H, et al. Nucl Med Biol. 2017 Feb;45:15-21. doi: 10.1016/j.nucmedbio.2016.10.004. Epub 2016 Oct 18. Nucl Med Biol. 2017. PMID: 27837664
Binding specificity, affinity and cellular processing (44)Sc-DOTA-Z(HER2:2891) and (68)Ga-DOTA-Z(HER2:2891) were compared in vitro using HER2-expressing cells. ...The distribution of radioactivity at 3h post injection was similar for (44)Sc-DOTA-Z(HER2:2891) …
Binding specificity, affinity and cellular processing (44)Sc-DOTA-Z(HER2:2891) and (68)Ga-DOTA-Z(HER2:2891) were compared in v …
Influence of DOTA chelator position on biodistribution and targeting properties of (111)In-labeled synthetic anti-HER2 affibody molecules.
Perols A, Honarvar H, Strand J, Selvaraju R, Orlova A, Karlström AE, Tolmachev V. Perols A, et al. Bioconjug Chem. 2012 Aug 15;23(8):1661-70. doi: 10.1021/bc3002369. Epub 2012 Jul 17. Bioconjug Chem. 2012. PMID: 22768790
In this comparative study, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) was conjugated to the synthetic affibody molecule Z(HER2:S1) at three different positions: DOTA-A1-Z(HER2:S1) (N-terminus), DOTA-K58-Z(HER2:S1) (C-terminus), and DOTA-K …
In this comparative study, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) was conjugated to the synthetic affibody molecule …
Evaluation of affibody molecule-based PNA-mediated radionuclide pretargeting: Development of an optimized conjugation protocol and 177Lu labeling.
Altai M, Westerlund K, Velletta J, Mitran B, Honarvar H, Karlström AE. Altai M, et al. Nucl Med Biol. 2017 Nov;54:1-9. doi: 10.1016/j.nucmedbio.2017.07.003. Epub 2017 Jul 12. Nucl Med Biol. 2017. PMID: 28810153
In this article we have further developed this approach by optimizing the production of the primary agent, Z(HER2:342)-SR-HP1, and labeling the secondary agent, HP2, with the therapeutic radionuclide (177)Lu. ...Co-injection with either Gelofusine or lysine significantly r …
In this article we have further developed this approach by optimizing the production of the primary agent, Z(HER2:342)-SR-HP1, and la …
Design, Preparation, and Characterization of PNA-Based Hybridization Probes for Affibody-Molecule-Mediated Pretargeting.
Westerlund K, Honarvar H, Tolmachev V, Eriksson Karlström A. Westerlund K, et al. Bioconjug Chem. 2015 Aug 19;26(8):1724-36. doi: 10.1021/acs.bioconjchem.5b00292. Epub 2015 Jul 6. Bioconjug Chem. 2015. PMID: 26086597
Circular dichroism (CD) spectroscopy and UV thermal melts showed that the probes can hybridize to form a structured duplex with a very high melting temperature (T(m)), both in HP1:HP2 and in Z(HER2:342)-SR-HP1:HP2 (T(m) = 86-88 C), and the high binding affinity between …
Circular dichroism (CD) spectroscopy and UV thermal melts showed that the probes can hybridize to form a structured duplex with a very high …
The effects of mobile health interventions on lipid profiles among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials.
Akbari M, Lankarani KB, Naghibzadeh-Tahami A, Tabrizi R, Honarvar B, Kolahdooz F, Borhaninejad V, Asemi Z. Akbari M, et al. Diabetes Metab Syndr. 2019 May-Jun;13(3):1949-1955. doi: 10.1016/j.dsx.2019.04.011. Epub 2019 Apr 12. Diabetes Metab Syndr. 2019. PMID: 31235120
Caspase and proteasome activity during staurosporin-induced apoptosis in lens epithelial cells.
Andersson M, Sjöstrand J, Petersen A, Honarvar AK, Karlsson JO. Andersson M, et al. Invest Ophthalmol Vis Sci. 2000 Aug;41(9):2623-32. Invest Ophthalmol Vis Sci. 2000. PMID: 10937575
Inhibition of the proteasome was performed by incubation with 10 microM lactacystin, and caspases were inhibited by 1 microM Z-DEVD-FMK or 20 microM Z-VAD-FMK. RESULTS: Staurosporin treatment caused a dose- and time-dependent increase in the number of apoptotic cell …
Inhibition of the proteasome was performed by incubation with 10 microM lactacystin, and caspases were inhibited by 1 microM Z-DEVD-F …