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Page 1
Showing results for z arg arg
Search for Z Zargari instead (1 results)
A Single Nucleotide Polymorphism in SH2B3/LNK Promotes Hypertension Development and Renal Damage.
Alexander MR, Hank S, Dale BL, Himmel L, Zhong X, Smart CD, Fehrenbach DJ, Chen Y, Prabakaran N, Tirado B, Centrella M, Ao M, Du L, Shyr Y, Levy D, Madhur MS. Alexander MR, et al. Circ Res. 2022 Oct 14;131(9):731-747. doi: 10.1161/CIRCRESAHA.121.320625. Epub 2022 Sep 28. Circ Res. 2022. PMID: 36169218 Free PMC article.
Cytokine production and Stat4 phosphorylation was also assessed in Arg/Arg and Trp/Trp T cells. RESULTS: Trp/Trp mice exhibit 10 mmHg higher systolic BP during chronic Ang II infusion compared to Arg/Arg controls. Renal injury and perivascular fibrosis …
Cytokine production and Stat4 phosphorylation was also assessed in Arg/Arg and Trp/Trp T cells. RESULTS: Trp/Trp mice exhibit …
Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range.
Yoon MC, Phan V, Podvin S, Mosier C, O'Donoghue AJ, Hook V. Yoon MC, et al. Biochemistry. 2023 Aug 1;62(15):2289-2300. doi: 10.1021/acs.biochem.3c00139. Epub 2023 Jul 17. Biochemistry. 2023. PMID: 37459182 Free PMC article.
Current substrates used to monitor cathepsin B activity consist of Z-Phe-Arg-AMC and Z-Arg-Arg-AMC, but they lack specificity since they are cleaved by other cysteine cathepsins. Furthermore, Z-Arg-Arg-AMC monitors cathepsin B acti …
Current substrates used to monitor cathepsin B activity consist of Z-Phe-Arg-AMC and Z-Arg-Arg-AMC, but they lac …
A single exon-encoded Theileria parva strain Muguga cysteine protease (ThpCP): Molecular modelling and characterisation.
Chauke E, Pelle R, Coetzer THT. Chauke E, et al. Biochimie. 2023 Mar;206:24-35. doi: 10.1016/j.biochi.2022.09.018. Epub 2022 Oct 2. Biochimie. 2023. PMID: 36198333
Purified ThpCP hydrolysed typical cathepsin L substrates N-alpha-benzyloxycarbonyl (Z)-Phe-Arg-7-amino-4-methyl-coumarin (AMC) (k(cat)/K(m) = 4.49 10(5) s(-1)M(-1)) and Z-Leu-Arg-AMC (k(cat)/K(m) = 4.20 10(5) s(-1)M(-1)), but showed no activity against the cathepsin …
Purified ThpCP hydrolysed typical cathepsin L substrates N-alpha-benzyloxycarbonyl (Z)-Phe-Arg-7-amino-4-methyl-coumarin (AMC) (k(cat …
Identification and characteristics of a cathepsin L-like cysteine protease from Clonorchis sinensis.
Ma C, Liang K, Tang L, He S, Liu X, He M, Li Y. Ma C, et al. Parasitol Res. 2019 Mar;118(3):829-835. doi: 10.1007/s00436-019-06223-y. Epub 2019 Jan 28. Parasitol Res. 2019. PMID: 30689051
After refolding, the recombinant CsCPL-m displayed optimal protease activity towards Z-Phe-Arg-AMC substrates but not towards Z-Arg-Arg-AMC, and the activity of the protease was inhibited completely by the cysteine protease-specific inhibitors E-64 and …
After refolding, the recombinant CsCPL-m displayed optimal protease activity towards Z-Phe-Arg-AMC substrates but not towards Z …
Characterization of intestinally active proteinases of cyst-nematodes.
Lilley CJ, Urwin PE, McPherson MJ, Atkinson HJ. Lilley CJ, et al. Parasitology. 1996 Oct;113 ( Pt 4):415-24. doi: 10.1017/s0031182000066555. Parasitology. 1996. PMID: 8873479
A cathepsin L-like cysteine proteinase activity capable of hydrolysing the synthetic substrates Z-Ala-Arg-Arg-MNA and Z-Phe-Arg-MNA but not Z-Arg-Arg-MNA or L-Arg-NA was inhibited by an engineered variant of a cysteine proteinase i …
A cathepsin L-like cysteine proteinase activity capable of hydrolysing the synthetic substrates Z-Ala-Arg-Arg-MNA and …
Echinococcus multilocularis: identification and functional characterization of cathepsin B-like peptidases from metacestode.
Sako Y, Nakaya K, Ito A. Sako Y, et al. Exp Parasitol. 2011 Mar;127(3):693-701. doi: 10.1016/j.exppara.2010.11.005. Epub 2010 Nov 21. Exp Parasitol. 2011. PMID: 21095185
Recombinant EmCBP1 and EmCBP2 expressed in Pichia pastoris, at optimum pH 5.5, exhibited substrate preferences for Z-Phe-Arg-MCA, Z-Val-Val-Arg-MCA, and Z-Leu-Arg-MCA, and low levels of hydrolysis of Z-Arg-Arg-MCA. ...
Recombinant EmCBP1 and EmCBP2 expressed in Pichia pastoris, at optimum pH 5.5, exhibited substrate preferences for Z-Phe-Arg-MCA, …
Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4.
Na BK, Bae YA, Zo YG, Choe Y, Kim SH, Desai PV, Avery MA, Craik CS, Kim TS, Rosenthal PJ, Kong Y. Na BK, et al. PLoS Negl Trop Dis. 2010 Oct 12;4(10):e849. doi: 10.1371/journal.pntd.0000849. PLoS Negl Trop Dis. 2010. PMID: 20967286 Free PMC article.
Its hydrolyzing activity against benzyloxycarbonyl-Leu-Arg-4-methyl-coumaryl-7-amide (Z-Leu-Arg-MCA) and Z-Phe-Arg-MCA was highest at acidic pH (5.5), whereas that against Z-Arg-Arg-MCA was maximal at neutral pH (6.5-7.5). ...Three amino acids t …
Its hydrolyzing activity against benzyloxycarbonyl-Leu-Arg-4-methyl-coumaryl-7-amide (Z-Leu-Arg-MCA) and Z-Phe-Arg-MCA was hig …
Resistance of bromelain to SDS binding.
Bhattacharya R, Bhattacharyya D. Bhattacharya R, et al. Biochim Biophys Acta. 2009 Apr;1794(4):698-708. doi: 10.1016/j.bbapap.2008.12.019. Epub 2009 Jan 7. Biochim Biophys Acta. 2009. PMID: 19162252
Below 5 mM, SDS caused large decrease in V(max) without affecting K(m) for the substrate Z-Arg-Arg-NHMec. Analysis of kinetic data imply that SDS acts as a partial non-competitive inhibitor since even at 100 mM, the residual activity of bromelain was retained …
Below 5 mM, SDS caused large decrease in V(max) without affecting K(m) for the substrate Z-Arg-Arg-NHMec. Analysis of k …
The specificity of trichomonad cysteine proteinases analysed using fluorogenic substrates and specific inhibitors.
North MJ, Robertson CD, Coombs GH. North MJ, et al. Mol Biochem Parasitol. 1990 Mar;39(2):183-93. doi: 10.1016/0166-6851(90)90057-s. Mol Biochem Parasitol. 1990. PMID: 2320056
Three types of enzyme were apparent in T. vaginalis: (i) an 86-kDa enzyme active only on Z-Arg-Arg-NHMec; (ii) a 54-kDa proteinase which was most active on Z-Phe-Arg-NHMec but also able to hydrolyse N-t-Boc-Val-Leu-Lys-NHMec, Suc-Ala-Phe-Lys-NHMec, H-P …
Three types of enzyme were apparent in T. vaginalis: (i) an 86-kDa enzyme active only on Z-Arg-Arg-NHMec; (ii) a 54-kDa …
New Glutamine-Containing Substrates for the Assay of Cysteine Peptidases From the C1 Papain Family.
Filippova IY, Dvoryakova EA, Sokolenko NI, Simonyan TR, Tereshchenkova VF, Zhiganov NI, Dunaevsky YE, Belozersky MA, Oppert B, Elpidina EN. Filippova IY, et al. Front Mol Biosci. 2020 Oct 22;7:578758. doi: 10.3389/fmolb.2020.578758. eCollection 2020. Front Mol Biosci. 2020. PMID: 33195423 Free PMC article.
We demonstrate that using Glp-Phe-Gln-pNA in combination with a commercially available substrate, Z-Arg-Arg-pNA, provided differential determination of cathepsins L and B. ...
We demonstrate that using Glp-Phe-Gln-pNA in combination with a commercially available substrate, Z-Arg-Arg-pNA, provid …
166 results