Identification of novel anti-cancer agents by the synthesis and cellular screening of a noscapine-based library.
Nemati F, Bischoff-Kont I, Salehi P, Nejad-Ebrahimi S, Mohebbi M, Bararjanian M, Hadian N, Hassanpour Z, Jung Y, Schaerlaekens S, Lucena-Agell D, Oliva MA, Fürst R, Nasiri HR.
Nemati F, et al.
Bioorg Chem. 2021 Oct;115:105135. doi: 10.1016/j.bioorg.2021.105135. Epub 2021 Jun 30.
Bioorg Chem. 2021.
PMID: 34303039
The so generated library, consisting of fifty-seven derivatives of the natural product noscapine, was tested against MDA-MB-231 breast cancer cells in a cellular proliferation assay (with a Z' > 0.7). The screening resulted in the identification of two novel noscapine d …
The so generated library, consisting of fifty-seven derivatives of the natural product noscapine, was tested against MDA-MB-231 breast cance …