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Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity.
Choi ML, Chappard A, Singh BP, Maclachlan C, Rodrigues M, Fedotova EI, Berezhnov AV, De S, Peddie CJ, Athauda D, Virdi GS, Zhang W, Evans JR, Wernick AI, Zanjani ZS, Angelova PR, Esteras N, Vinokurov AY, Morris K, Jeacock K, Tosatto L, Little D, Gissen P, Clarke DJ, Kunath T, Collinson L, Klenerman D, Abramov AY, Horrocks MH, Gandhi S. Choi ML, et al. Nat Neurosci. 2022 Sep;25(9):1134-1148. doi: 10.1038/s41593-022-01140-3. Epub 2022 Aug 30. Nat Neurosci. 2022. PMID: 36042314 Free PMC article.
Impacts of bioreactor operating parameters on removal efficiency, biodegradation rate, molecular distribution, and toxicity of commercial naphthenic acids.
Zanjani H, Soltan J, Nemati M. Zanjani H, et al. Bioprocess Biosyst Eng. 2022 Feb;45(2):391-407. doi: 10.1007/s00449-021-02669-6. Epub 2021 Dec 2. Bioprocess Biosyst Eng. 2022. PMID: 34854976
Analysis of influent and treated effluents with gas chromatography-mass spectrometry showed that molecular weight and cyclicity (C and Z numbers) affected the biodegradation, with low molecular weight acyclic NAs (C = 6-12) were the most amenable to biodegradation and thos …
Analysis of influent and treated effluents with gas chromatography-mass spectrometry showed that molecular weight and cyclicity (C and Z