Synthesis and antitubercular activity of novel 4-substituted imidazolyl-2,6-dimethyl-N3,N5-bisaryl-1,4-dihydropyridine-3,5-dicarboxamides.
Fassihi A, Azadpour Z, Delbari N, Saghaie L, Memarian HR, Sabet R, Alborzi A, Miri R, Pourabbas B, Mardaneh J, Mousavi P, Moeinifard B, Sadeghi-Aliabadi H.
Fassihi A, et al.
Eur J Med Chem. 2009 Aug;44(8):3253-8. doi: 10.1016/j.ejmech.2009.03.027. Epub 2009 Mar 27.
Eur J Med Chem. 2009.
PMID: 19371979
Compound 3i with 1-benzyl-2-methylthio-1H-imidazole-5-yl substituent at C-4 position and 4'-chloromophenyl group at C-3 and C-5 positions of the 1,4-dihydropyridine ring was the most potent one among the tested compounds. It was as potent as rifampicin against M. tuberculo …
Compound 3i with 1-benzyl-2-methylthio-1H-imidazole-5-yl substituent at C-4 position and 4'-chloromophenyl group at C-3 and C-5 positions of …