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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1975 1
1976 2
1977 2
1978 2
1979 2
1980 2
1981 1
1982 2
1984 2
1986 3
1987 1
1988 1
1989 4
1990 5
1991 3
1992 4
1993 1
1994 8
1995 12
1996 5
1997 12
1998 6
1999 14
2000 21
2001 17
2002 16
2003 12
2004 16
2005 25
2006 21
2007 27
2008 26
2009 25
2010 34
2011 28
2012 36
2013 51
2014 75
2015 89
2016 95
2017 107
2018 118
2019 149
2020 184
2021 194
2022 177
2023 192
2024 75

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1,721 results

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Page 1
Ligand and G-protein selectivity in the κ-opioid receptor.
Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T. Han J, et al. Nature. 2023 May;617(7960):417-425. doi: 10.1038/s41586-023-06030-7. Epub 2023 May 3. Nature. 2023. PMID: 37138078 Free PMC article.
Therapeutic drug monitoring-guided treatment versus standard dosing of voriconazole for invasive aspergillosis in haematological patients: a multicentre, prospective, cluster randomised, crossover clinical trial.
Veringa A, Brüggemann RJ, Span LFR, Biemond BJ, de Boer MGJ, van den Heuvel ER, Klein SK, Kraemer D, Minnema MC, Prakken NHJ, Rijnders BJA, Swen JJ, Verweij PE, Wondergem MJ, Ypma PF, Blijlevens N, Kosterink JGW, van der Werf TS, Alffenaar JC; Voriconazole ZonMw Study Group. Veringa A, et al. Int J Antimicrob Agents. 2023 Feb;61(2):106711. doi: 10.1016/j.ijantimicag.2023.106711. Epub 2023 Jan 13. Int J Antimicrob Agents. 2023. PMID: 36642232 Free article. Clinical Trial.
This study aimed to investigate whether TDM-guided voriconazole treatment is superior to standard treatment for invasive aspergillosis. METHODS: A multicentre (n = 10), prospective, cluster randomised, crossover clinical trial was performed in haematological patients aged …
This study aimed to investigate whether TDM-guided voriconazole treatment is superior to standard treatment for invasive aspergillosis. METH …
Piperlongumine conjugates induce targeted protein degradation.
Pei J, Xiao Y, Liu X, Hu W, Sobh A, Yuan Y, Zhou S, Hua N, Mackintosh SG, Zhang X, Basso KB, Kamat M, Yang Q, Licht JD, Zheng G, Zhou D, Lv D. Pei J, et al. Cell Chem Biol. 2023 Feb 16;30(2):203-213.e17. doi: 10.1016/j.chembiol.2023.01.004. Epub 2023 Feb 6. Cell Chem Biol. 2023. PMID: 36750097 Free PMC article.
Cellular senescence and radiation-induced pulmonary fibrosis.
He Y, Thummuri D, Zheng G, Okunieff P, Citrin DE, Vujaskovic Z, Zhou D. He Y, et al. Transl Res. 2019 Jul;209:14-21. doi: 10.1016/j.trsl.2019.03.006. Epub 2019 Mar 27. Transl Res. 2019. PMID: 30981698 Free PMC article. Review.
GZ-11608, a Vesicular Monoamine Transporter-2 Inhibitor, Decreases the Neurochemical and Behavioral Effects of Methamphetamine.
Lee NR, Zheng G, Leggas M, Janganati V, Nickell JR, Crooks PA, Bardo MT, Dwoskin LP. Lee NR, et al. J Pharmacol Exp Ther. 2019 Nov;371(2):526-543. doi: 10.1124/jpet.119.258699. Epub 2019 Aug 14. J Pharmacol Exp Ther. 2019. PMID: 31413138 Free PMC article.
The current study determined if replacement of GZ-793A's piperidine ring with a phenylalkyl group to yield S-3-(4-methoxyphenyl)-N-(1-phenylpropan-2-yl)propan-1-amine (GZ-11608) diminished hERG interaction while retaining pharmacological efficacy. ...GZ …
The current study determined if replacement of GZ-793A's piperidine ring with a phenylalkyl group to yield S-3-(4-methoxyphenyl)-N …
Effects of positive acceleration (+Gz stress) on liver enzymes, energy metabolism, and liver histology in rats.
Shi B, Wang XQ, Duan WD, Tan GD, Gao HJ, Pan YW, Guo QJ, Zhang HY. Shi B, et al. World J Gastroenterol. 2019 Jan 21;25(3):346-355. doi: 10.3748/wjg.v25.i3.346. World J Gastroenterol. 2019. PMID: 30686902 Free PMC article.
AIM: To investigate rat liver function changes in response to repeated +Gz exposure. METHODS: Ninety male Wistar rats were randomly divided into a blank control group (BC group, n = 30), a +6 Gz/5 min stress group (6GS group, n = 30), and a +10 Gz …
AIM: To investigate rat liver function changes in response to repeated +Gz exposure. METHODS: Ninety male Wistar rats were randomly d …
Urinary Excretion of N(1)-Methylnicotinamide and N(1)-Methyl-2-Pyridone-5-Carboxamide and Mortality in Kidney Transplant Recipients.
Deen CPJ, Veen AV, Gomes-Neto AW, Geleijnse JM, Berg KJBD, Heiner-Fokkema MR, Kema IP, Bakker SJL. Deen CPJ, et al. Nutrients. 2020 Jul 10;12(7):2059. doi: 10.3390/nu12072059. Nutrients. 2020. PMID: 32664445 Free PMC article.
However, recent evidence implies higher enzymatic conversion of N(1)-MN to N(1)-methyl-2-pyridone-5-carboxamide (2Py) in KTR, therefore the need exists for interpretation of both N(1)-MN and 2Py excretion for niacin status assessment. We assessed niacin statu …
However, recent evidence implies higher enzymatic conversion of N(1)-MN to N(1)-methyl-2-pyridone-5-carboxamide (2Py) in KTR, …
Urinary Excretion of N(1)-methyl-2-pyridone-5-carboxamide and N(1)-methylnicotinamide in Renal Transplant Recipients and Donors.
Deen CPJ, van der Veen A, Gomes-Neto AW, Geleijnse JM, Borgonjen-van den Berg KJ, Heiner-Fokkema MR, Kema IP, Bakker SJL. Deen CPJ, et al. J Clin Med. 2020 Feb 6;9(2):437. doi: 10.3390/jcm9020437. J Clin Med. 2020. PMID: 32041099 Free PMC article.
N(1)-methylnicotinamide (N(1)-MN) and N(1)-methyl-2-pyridone-5-carboxamide (2Py) are successive end products of NAD(+) catabolism. ...However, it is unclear whether 2Py excretion is increased in this population, and, if so, whether a shift in excretion of …
N(1)-methylnicotinamide (N(1)-MN) and N(1)-methyl-2-pyridone-5-carboxamide (2Py) are successive end products of NAD(+) …
Discovery and In Vitro Characterization of SPL028: Deuterated N,N-Dimethyltryptamine.
Layzell M, Rands P, Good M, Joel Z, Cousins R, Benway T, James E, Routledge C. Layzell M, et al. ACS Med Chem Lett. 2023 Aug 31;14(9):1216-1223. doi: 10.1021/acsmedchemlett.3c00143. eCollection 2023 Sep 14. ACS Med Chem Lett. 2023. PMID: 37736183
The psychedelic N,N- dimethyltryptamine (DMT) is in clinical development for the treatment of major depressive disorder. ...The molecule with the greatest degree of deuteration at the alpha-carbon (N,N-D(2)-dimethyltryptamine, D(2)-DMT) demonstrated th …
The psychedelic N,N- dimethyltryptamine (DMT) is in clinical development for the treatment of major depressive disorder. ...Th …
The effects of strength training and centrifuge exposure on +Gz tolerance.
Bulbulian R, Crisman RP, Thomas ML, Meyer LG. Bulbulian R, et al. Aviat Space Environ Med. 1994 Dec;65(12):1097-104. Aviat Space Environ Med. 1994. PMID: 7872910 Review.
This study examines factors associated with WT in an operational environment as a countermeasure to +Gz intolerance. Fourteen naval aviators were assigned to a WT group (n = 7) and a non-weight-trained control (NWT) group (n = 7). All subjects were tested bef …
This study examines factors associated with WT in an operational environment as a countermeasure to +Gz intolerance. Fourteen naval a …
1,721 results