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Correlation of Peripheral Immunity With Rapid Amyotrophic Lateral Sclerosis Progression.
Murdock BJ, Zhou T, Kashlan SR, Little RJ, Goutman SA, Feldman EL. Murdock BJ, et al. JAMA Neurol. 2017 Dec 1;74(12):1446-1454. doi: 10.1001/jamaneurol.2017.2255. JAMA Neurol. 2017. PMID: 28973548 Free PMC article.
IMPORTANCE: Amyotrophic lateral sclerosis (ALS) has an immune component, but previous human studies have not examined immune changes over time. ...Multivariate regression models were used to correlate changes in immune metrics with …
IMPORTANCE: Amyotrophic lateral sclerosis (ALS) has an immune component, but previous human studies have not exa …
Involvement of muscle satellite cell dysfunction in neuromuscular disorders: Expanding the portfolio of satellite cell-opathies.
Ganassi M, Zammit PS. Ganassi M, et al. Eur J Transl Myol. 2022 Mar 18;32(1):10064. doi: 10.4081/ejtm.2022.10064. Eur J Transl Myol. 2022. PMID: 35302338 Free PMC article.
In addition to directly affecting skeletal muscle, pathogenesis can also arise from dysfunctional crosstalk between nerves and muscles, and may include cardiac impairment. Muscular weakness is often progressive and paralleled by continuous decline in the ability of skeleta …
In addition to directly affecting skeletal muscle, pathogenesis can also arise from dysfunctional crosstalk between nerves and muscles, and …
Neuroinflammatory mechanisms in amyotrophic lateral sclerosis pathogenesis.
Thonhoff JR, Simpson EP, Appel SH. Thonhoff JR, et al. Curr Opin Neurol. 2018 Oct;31(5):635-639. doi: 10.1097/WCO.0000000000000599. Curr Opin Neurol. 2018. PMID: 30048339 Review.
PURPOSE OF REVIEW: Neuroinflammation is increasingly recognized as an important mediator of disease progression in patients with amyotrophic lateral sclerosis (ALS), and is characterized by reactive central nervous system (CNS) microglia and ast …
PURPOSE OF REVIEW: Neuroinflammation is increasingly recognized as an important mediator of disease progression in patients wi …
Amyotrophic lateral sclerosis patients show increased peripheral and intrathecal T-cell activation.
Rolfes L, Schulte-Mecklenbeck A, Schreiber S, Vielhaber S, Herty M, Marten A, Pfeuffer S, Ruck T, Wiendl H, Gross CC, Meuth SG, Boentert M, Pawlitzki M. Rolfes L, et al. Brain Commun. 2021 Jul 14;3(3):fcab157. doi: 10.1093/braincomms/fcab157. eCollection 2021. Brain Commun. 2021. PMID: 34405141 Free PMC article.
Several studies suggest a role for the peripheral immune system in the pathophysiology of amyotrophic lateral sclerosis. ...Intrathecal T-cell activation resulted from in situ activation rather than transmigration of activated T cells from the b …
Several studies suggest a role for the peripheral immune system in the pathophysiology of amyotrophic lateral
A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis.
Cooper-Knock J, Green C, Altschuler G, Wei W, Bury JJ, Heath PR, Wyles M, Gelsthorpe C, Highley JR, Lorente-Pons A, Beck T, Doyle K, Otero K, Traynor B, Kirby J, Shaw PJ, Hide W. Cooper-Knock J, et al. Acta Neuropathol Commun. 2017 Mar 16;5(1):23. doi: 10.1186/s40478-017-0424-x. Acta Neuropathol Commun. 2017. PMID: 28302159 Free PMC article.
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that lacks a predictive and broadly applicable biomarker. ...Genes in the network module are important for microglial activation and predict disease progression
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that lacks a predictive and broad