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Correlation of Peripheral Immunity With Rapid Amyotrophic Lateral Sclerosis Progression.
Murdock BJ, Zhou T, Kashlan SR, Little RJ, Goutman SA, Feldman EL. Murdock BJ, et al. JAMA Neurol. 2017 Dec 1;74(12):1446-1454. doi: 10.1001/jamaneurol.2017.2255. JAMA Neurol. 2017. PMID: 28973548 Free PMC article.
IMPORTANCE: Amyotrophic lateral sclerosis (ALS) has an immune component, but previous human studies have not examined immune changes over time. ...Multivariate regression models were used to correlate changes in immune metrics with …
IMPORTANCE: Amyotrophic lateral sclerosis (ALS) has an immune component, but previous human studies have not exa …
Neuroinflammatory mechanisms in amyotrophic lateral sclerosis pathogenesis.
Thonhoff JR, Simpson EP, Appel SH. Thonhoff JR, et al. Curr Opin Neurol. 2018 Oct;31(5):635-639. doi: 10.1097/WCO.0000000000000599. Curr Opin Neurol. 2018. PMID: 30048339 Review.
PURPOSE OF REVIEW: Neuroinflammation is increasingly recognized as an important mediator of disease progression in patients with amyotrophic lateral sclerosis (ALS), and is characterized by reactive central nervous system (CNS) microglia and ast …
PURPOSE OF REVIEW: Neuroinflammation is increasingly recognized as an important mediator of disease progression in patients wi …
A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis.
Cooper-Knock J, Green C, Altschuler G, Wei W, Bury JJ, Heath PR, Wyles M, Gelsthorpe C, Highley JR, Lorente-Pons A, Beck T, Doyle K, Otero K, Traynor B, Kirby J, Shaw PJ, Hide W. Cooper-Knock J, et al. Acta Neuropathol Commun. 2017 Mar 16;5(1):23. doi: 10.1186/s40478-017-0424-x. Acta Neuropathol Commun. 2017. PMID: 28302159 Free PMC article.
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that lacks a predictive and broadly applicable biomarker. ...Genes in the network module are important for microglial activation and predict disease progression
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that lacks a predictive and broad
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