Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
1981 1
1982 1
1983 1
1985 2
1986 1
1987 4
1988 3
1989 4
1990 5
1991 4
1992 6
1993 4
1994 6
1995 3
1996 10
1997 6
1998 10
1999 3
2000 5
2001 8
2002 10
2003 6
2004 7
2005 13
2006 8
2007 8
2008 9
2009 15
2010 12
2011 16
2012 14
2013 16
2014 16
2015 11
2016 15
2017 13
2018 7
2019 1
2020 5
2021 12
2022 14
2023 7
2024 2

Text availability

Article attribute

Article type

Publication date

Search Results

298 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial.
Tesfaye S, Sloan G, Petrie J, White D, Bradburn M, Julious S, Rajbhandari S, Sharma S, Rayman G, Gouni R, Alam U, Cooper C, Loban A, Sutherland K, Glover R, Waterhouse S, Turton E, Horspool M, Gandhi R, Maguire D, Jude EB, Ahmed SH, Vas P, Hariman C, McDougall C, Devers M, Tsatlidis V, Johnson M, Rice ASC, Bouhassira D, Bennett DL, Selvarajah D; OPTION-DM trial group. Tesfaye S, et al. Lancet. 2022 Aug 27;400(10353):680-690. doi: 10.1016/S0140-6736(22)01472-6. Epub 2022 Aug 22. Lancet. 2022. PMID: 36007534 Free PMC article. Clinical Trial.
BACKGROUND: Diabetic peripheral neuropathic pain (DPNP) is common and often distressing. Most guidelines recommend amitriptyline, duloxetine, pregabalin, or gabapentin as initial analgesic treatment for DPNP, but there is little comparative evidence on which one is …
BACKGROUND: Diabetic peripheral neuropathic pain (DPNP) is common and often distressing. Most guidelines recommend amitriptyline …
Amitriptyline for neuropathic pain in adults.
Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ. Moore RA, et al. Cochrane Database Syst Rev. 2015 Jul 6;2015(7):CD008242. doi: 10.1002/14651858.CD008242.pub3. Cochrane Database Syst Rev. 2015. PMID: 26146793 Free PMC article. Review.
BACKGROUND: This is an updated version of the original Cochrane review published in Issue 12, 2012. That review considered both fibromyalgia and neuropathic pain, but the effects of amitriptyline for fibromyalgia are now dealt with in a separate review.Amitriptyl …
BACKGROUND: This is an updated version of the original Cochrane review published in Issue 12, 2012. That review considered both fibromyalgia …
Amitriptyline for neuropathic pain and fibromyalgia in adults.
Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ. Moore RA, et al. Cochrane Database Syst Rev. 2012 Dec 12;12:CD008242. doi: 10.1002/14651858.CD008242.pub2. Cochrane Database Syst Rev. 2012. PMID: 23235657 Updated. Review.
BACKGROUND: Amitriptyline is a tricyclic antidepressant that is widely used to treat chronic neuropathic pain (pain due to nerve damage) and fibromyalgia, and is recommended in many guidelines. ...OBJECTIVES: To assess the analgesic efficacy of amitriptyli …
BACKGROUND: Amitriptyline is a tricyclic antidepressant that is widely used to treat chronic neuropathic pain (pain due …
Pharmacologic interventions for treating phantom limb pain.
Alviar MJ, Hale T, Dungca M. Alviar MJ, et al. Cochrane Database Syst Rev. 2016 Oct 14;10(10):CD006380. doi: 10.1002/14651858.CD006380.pub3. Cochrane Database Syst Rev. 2016. PMID: 27737513 Free PMC article. Review.
BACKGROUND: This is an updated version of the original Cochrane review published in Issue 12, 2011. Phantom limb pain (PLP) is pain that arises in the missing limb after amputation and can be severe, intractable, and disabling. Various medications have been studied …
BACKGROUND: This is an updated version of the original Cochrane review published in Issue 12, 2011. Phantom limb pain (PLP) is pai …
Antioxidants Supplementation in Acute Amitriptyline Abuse for Pain.
Ali SHK, Raja KWA, Irfan N, Habeeb M, Ismail Y. Ali SHK, et al. Appl Biochem Biotechnol. 2022 Jan;194(1):556-569. doi: 10.1007/s12010-021-03721-7. Epub 2021 Oct 26. Appl Biochem Biotechnol. 2022. PMID: 34699040 Clinical Trial.
The fundamental aim of this study is to establish the role of antioxidant supplementation in alleviating acute amitriptyline induced oxidative stress. The effect of supplementation was compared on treatment of acute amitriptyline intoxication cases for pain m …
The fundamental aim of this study is to establish the role of antioxidant supplementation in alleviating acute amitriptyline induced …
Comparison of Amitriptyline and US Food and Drug Administration-Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis.
Farag HM, Yunusa I, Goswami H, Sultan I, Doucette JA, Eguale T. Farag HM, et al. JAMA Netw Open. 2022 May 2;5(5):e2212939. doi: 10.1001/jamanetworkopen.2022.12939. JAMA Netw Open. 2022. PMID: 35587348 Free PMC article.
Duloxetine 120 mg was associated with the highest improvement in pain (SMD, -0.33; 95% CrI, -0.36 to -0.30) and depression (SMD, -0.25; 95% CrI, -0.32 to -0.17) vs placebo. All treatments were associated with inferior acceptability (higher dropout rate) than placebo, excep …
Duloxetine 120 mg was associated with the highest improvement in pain (SMD, -0.33; 95% CrI, -0.36 to -0.30) and depression (SMD, -0.2 …
Efficacy of amitriptyline in pediatric functional abdominal pain disorders: A randomized placebo-controlled trial.
Seetharaman J, Poddar U, Yachha SK, Srivastava A, Sen Sarma M. Seetharaman J, et al. J Gastroenterol Hepatol. 2022 Apr;37(4):685-691. doi: 10.1111/jgh.15765. Epub 2022 Jan 22. J Gastroenterol Hepatol. 2022. PMID: 34935191 Clinical Trial.
Responders (> 50% reduction) in pain was seen in 76% in amitriptyline compared with 14.9% in the placebo group (P < 0.001). ...CONCLUSIONS: A 3-month trial of amitriptyline gives sustained relief of pain in two-thirds of children with FAPD. ...

Responders (> 50% reduction) in pain was seen in 76% in amitriptyline compared with 14.9% in the placebo group (P < 0.00

…
Comparative efficacy of amitriptyline, duloxetine and pregabalin for treating fibromyalgia in adults: an overview with network meta-analysis.
Alberti FF, Becker MW, Blatt CR, Ziegelmann PK, da Silva Dal Pizzol T, Pilger D. Alberti FF, et al. Clin Rheumatol. 2022 Jul;41(7):1965-1978. doi: 10.1007/s10067-022-06129-8. Epub 2022 Mar 26. Clin Rheumatol. 2022. PMID: 35347488 Review.
Treatment recommendations for fibromyalgia (FM) include a range of predominantly pharmacological treatment options designed to ensure the maintenance of symptoms and improvement in the quality of life of these patients. Our aim is to identify and compare the efficacy of amitri …
Treatment recommendations for fibromyalgia (FM) include a range of predominantly pharmacological treatment options designed to ensure the ma …
Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT.
Tesfaye S, Sloan G, Petrie J, White D, Bradburn M, Young T, Rajbhandari S, Sharma S, Rayman G, Gouni R, Alam U, Julious SA, Cooper C, Loban A, Sutherland K, Glover R, Waterhouse S, Turton E, Horspool M, Gandhi R, Maguire D, Jude E, Ahmed SH, Vas P, Hariman C, McDougall C, Devers M, Tsatlidis V, Johnson M, Bouhassira D, Bennett DL, Selvarajah D. Tesfaye S, et al. Health Technol Assess. 2022 Oct;26(39):1-100. doi: 10.3310/RXUO6757. Health Technol Assess. 2022. PMID: 36259684 Free PMC article. Clinical Trial.
SETTING: Twenty-one secondary care centres in the UK. PARTICIPANTS: Adults with diabetic peripheral neuropathic pain with a 7-day average self-rated pain score of 4 points (Numeric Rating Scale 0-10). ...RESULTS: A total of 140 participants were randomised from 13 U …
SETTING: Twenty-one secondary care centres in the UK. PARTICIPANTS: Adults with diabetic peripheral neuropathic pain with a 7-day ave …
What is the efficacy of aerobic exercise versus strength training in the treatment of migraine? A systematic review and network meta-analysis of clinical trials.
Woldeamanuel YW, Oliveira ABD. Woldeamanuel YW, et al. J Headache Pain. 2022 Oct 13;23(1):134. doi: 10.1186/s10194-022-01503-y. J Headache Pain. 2022. PMID: 36229774 Free PMC article. Review.
Studies that compared the efficacy of migraine medications (topiramate, amitriptyline) to exercise were included. Additionally, the risk of bias in all included studies was assessed by using the Cochrane Risk of Bias version 2 (RoB2). ...The rank of the interventions was a …
Studies that compared the efficacy of migraine medications (topiramate, amitriptyline) to exercise were included. Additionally, the r …
298 results