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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1980 1
1981 4
1982 4
1983 1
1984 1
1985 4
1987 2
1988 6
1989 3
1990 2
1991 4
1992 4
1993 5
1994 2
1995 4
1996 10
1997 6
1998 7
1999 11
2000 5
2001 10
2002 12
2003 14
2004 12
2005 20
2006 15
2007 14
2008 12
2009 18
2010 12
2011 10
2012 6
2013 8
2014 9
2015 9
2016 8
2017 3
2018 6
2019 9
2020 6
2021 4
2022 5
2023 6
2024 5

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311 results

Results by year

Filters applied: Meta-Analysis, Randomized Controlled Trial. Clear all
Page 1
Effect of Plasmodium falciparum sulfadoxine-pyrimethamine resistance on the effectiveness of intermittent preventive therapy for malaria in pregnancy in Africa: a systematic review and meta-analysis.
van Eijk AM, Larsen DA, Kayentao K, Koshy G, Slaughter DEC, Roper C, Okell LC, Desai M, Gutman J, Khairallah C, Rogerson SJ, Hopkins Sibley C, Meshnick SR, Taylor SM, Ter Kuile FO. van Eijk AM, et al. Lancet Infect Dis. 2019 May;19(5):546-556. doi: 10.1016/S1473-3099(18)30732-1. Epub 2019 Mar 25. Lancet Infect Dis. 2019. PMID: 30922818 Free article.
BACKGROUND: Resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine threatens the antimalarial effectiveness of intermittent preventive treatment during pregnancy (IPTp) in sub-Saharan Africa. We aimed to assess the associations between markers of sulfad …
BACKGROUND: Resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine threatens the antimalarial effectiveness of inter …
Risk of drug resistance in Plasmodium falciparum malaria therapy-a systematic review and meta-analysis.
Zhou LJ, Xia J, Wei HX, Liu XJ, Peng HJ. Zhou LJ, et al. Parasitol Res. 2017 Feb;116(2):781-788. doi: 10.1007/s00436-016-5353-2. Epub 2016 Dec 27. Parasitol Res. 2017. PMID: 28028628 Review.
Although a number of studies have reported the emergence of drug resistance in different therapies for P. falciparum infection, the degree of the drug resistance in different antimalarials is still unclear. This research investigated the risk of drug resistance …
Although a number of studies have reported the emergence of drug resistance in different therapies for P. falciparum infection, the d …
Effect of monthly intermittent preventive treatment with dihydroartemisinin-piperaquine with and without azithromycin versus monthly sulfadoxine-pyrimethamine on adverse pregnancy outcomes in Africa: a double-blind randomised, partly placebo-controlled trial.
Madanitsa M, Barsosio HC, Minja DTR, Mtove G, Kavishe RA, Dodd J, Saidi Q, Onyango ED, Otieno K, Wang D, Ashorn U, Hill J, Mukerebe C, Gesase S, Msemo OA, Mwapasa V, Phiri KS, Maleta K, Klein N, Magnussen P, Lusingu JPA, Kariuki S, Mosha JF, Alifrangis M, Hansson H, Schmiegelow C, Gutman JR, Chico RM, Ter Kuile FO. Madanitsa M, et al. Lancet. 2023 Mar 25;401(10381):1020-1036. doi: 10.1016/S0140-6736(22)02535-1. Epub 2023 Mar 10. Lancet. 2023. PMID: 36913959 Free PMC article. Clinical Trial.
BACKGROUND: Intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin-piperaquine is more effective than IPTp with sulfadoxine-pyrimethamine at reducing malaria infection during pregnancy in areas with high-grade resistance to sulfadoxine- …
BACKGROUND: Intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin-piperaquine is more effective than IPTp with su …
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P. Crider K, et al. Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217. Cochrane Database Syst Rev. 2022. PMID: 36321557 Free PMC article.
Due to increasing resistance to SP, in 2000 the WHO recommended that one of several artemisinin-based combination therapies (ACTs) be used instead of SP for the treatment of uncomplicated malaria caused by Plasmodium falciparum (Global Partnership to Roll Back Malaria 2001 …
Due to increasing resistance to SP, in 2000 the WHO recommended that one of several artemisinin-based combination therapies (ACTs) be …
Molecular markers of resistance to sulfadoxine-pyrimethamine during intermittent preventive treatment for malaria in Mozambican infants.
Mayor A, Serra-Casas E, Sanz S, Aponte JJ, Macete E, Mandomando I, Puyol L, Berzosa P, Dobaño C, Aide P, Sacarlal J, Benito A, Alonso P, Menéndez C. Mayor A, et al. J Infect Dis. 2008 Jun 15;197(12):1737-42. doi: 10.1086/588144. J Infect Dis. 2008. PMID: 18419347 Clinical Trial.
BACKGROUND: Intermittent preventive treatment in infants (IPTi) with sulfadoxine-pyrimethamine (SP) is a potential malaria control strategy. There is concern about the impact that increasing in vivo resistance to SP has on the efficacy of IPTi, as well as about the …
BACKGROUND: Intermittent preventive treatment in infants (IPTi) with sulfadoxine-pyrimethamine (SP) is a potential malaria control st …
Polymorphism in PfMRP1 (Plasmodium falciparum multidrug resistance protein 1) amino acid 1466 associated with resistance to sulfadoxine-pyrimethamine treatment.
Dahlström S, Veiga MI, Mårtensson A, Björkman A, Gil JP. Dahlström S, et al. Antimicrob Agents Chemother. 2009 Jun;53(6):2553-6. doi: 10.1128/AAC.00091-09. Epub 2009 Apr 13. Antimicrob Agents Chemother. 2009. PMID: 19364873 Free PMC article. Clinical Trial.
Resistance to SP is increasing and associated primarily with mutations in the P. falciparum dhfr (Pfdhfr) and Pfdhps genes. ...Our data point for the first time to a role for a P. falciparum multidrug resistance protein homologue in the antimalarial activity of SP. …
Resistance to SP is increasing and associated primarily with mutations in the P. falciparum dhfr (Pfdhfr) and Pfdhps genes. ...Our da …
Sulfadoxine-pyrimethamine plus artesunate versus sulfadoxine-pyrimethamine plus amodiaquine for treating uncomplicated malaria.
Bukirwa H, Critchley J. Bukirwa H, et al. Cochrane Database Syst Rev. 2006 Jan 25;2006(1):CD004966. doi: 10.1002/14651858.CD004966.pub2. Cochrane Database Syst Rev. 2006. PMID: 16437507 Free PMC article. Review.
AUTHORS' CONCLUSIONS: SP plus AQ performed better at controlling treatment failure at day 28, but was not as good as SP plus AS at reducing gametocyte carriage at day seven. Careful consideration of local resistance patterns is required because resistance to sulf …
AUTHORS' CONCLUSIONS: SP plus AQ performed better at controlling treatment failure at day 28, but was not as good as SP plus AS at reducing …
High level of resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine in children in Tanzania.
Rønn AM, Msangeni HA, Mhina J, Wernsdorfer WH, Bygbjerg IC. Rønn AM, et al. Trans R Soc Trop Med Hyg. 1996 Mar-Apr;90(2):179-81. doi: 10.1016/s0035-9203(96)90129-7. Trans R Soc Trop Med Hyg. 1996. PMID: 8761583 Clinical Trial.
In many areas of tropical Africa affected by chloroquine-resistant Plasmodium falciparum, a combination of sulfadoxine and pyrimethamine (S-P) is used for alternative medication, especially in young children. ...
In many areas of tropical Africa affected by chloroquine-resistant Plasmodium falciparum, a combination of sulfadoxine and pyr …
Dihydroartemisinin-Piperaquine for the Prevention of Malaria in Pregnancy.
Kakuru A, Jagannathan P, Muhindo MK, Natureeba P, Awori P, Nakalembe M, Opira B, Olwoch P, Ategeka J, Nayebare P, Clark TD, Feeney ME, Charlebois ED, Rizzuto G, Muehlenbachs A, Havlir DV, Kamya MR, Dorsey G. Kakuru A, et al. N Engl J Med. 2016 Mar 10;374(10):928-39. doi: 10.1056/NEJMoa1509150. N Engl J Med. 2016. PMID: 26962728 Free PMC article. Clinical Trial.
However, with the spread of resistance to sulfadoxine-pyrimethamine, new interventions are needed. METHODS: We conducted a double-blind, randomized, controlled trial involving 300 human immunodeficiency virus (HIV)-uninfected pregnant adolescents or women in Uganda, …
However, with the spread of resistance to sulfadoxine-pyrimethamine, new interventions are needed. METHODS: We conducted a dou …
Meta-analysis on Plasmodium falciparum sulfadoxine-pyrimethamine resistance-conferring mutations in India identifies hot spots for genetic surveillance.
Sinha A, Kar S, Chauhan C, Yadav CP, Kori L. Sinha A, et al. Int J Antimicrob Agents. 2024 Mar;63(3):107071. doi: 10.1016/j.ijantimicag.2023.107071. Epub 2023 Dec 27. Int J Antimicrob Agents. 2024. PMID: 38154659 Free article.
BACKGROUND: India is on track to eliminate malaria by 2030 but emerging resistance to first-line antimalarials is a recognised threat. Two instances of rapid development, spread, and natural selection of drug-resistant mutant parasites in India (chloroquine across t …
BACKGROUND: India is on track to eliminate malaria by 2030 but emerging resistance to first-line antimalarials is a recognised threat …
311 results